Kathy Niakan: Publications

  • Wamaitha, SE and Niakan, KK (2018)
    Human pre-gastrulation development.
    Current Topics in Developmental Biology 128, 295-338 PubMed abstract
  • Blakeley, P; Fogarty, N; Del Valle, I; Wamaitha, S; Hu, TX; Elder, K; Snell, P; Christie, L; Robson, P and Niakan, K (2017)
    Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.
    Mechanisms of Development 145, S26, Abstract no. PS21.28
  • Fogarty, NME; McCarthy, A; Snijders, KE; Powell, BE; Kubikova, N; Blakeley, P; Lea, R; Elder, K; Wamaitha, SE; Kim, D; Maciulyte, V; Kleinjung, J; Kim, J-S; Wells, D; Vallier, L; Bertero, A; Turner, JMA and Niakan, KK (2017)
    Genome editing reveals a role for OCT4 in human embryogenesis.
    Nature 550, 67-73 PubMed abstract
  • Gialitakis, M; Tolaini, M; Li, Y; Pardo, M; Yu, L; Toribio, A; Choudhary, JS; Niakan, K; Papayannopoulos, V and Stockinger, B (2017)
    Activation of the aryl hydrocarbon receptor interferes with early embryonic development.
    Stem Cell Reports 9, 1377-1386 PubMed abstract
  • Tomaz, RA; Harman, JL; Karimlou, D; Weavers, L; Fritsch, L; Bou-Kheir, T; Bell, E; del Valle Torres, I; Niakan, KK; Fisher, C; Joshi, O; Stunnenberg, HG; Curry, E; Ait-Si-Ali, S; Jørgensen, HF and Azuara, V (2017)
    Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.
    Development 144, 567-579 PubMed abstract
  • Hyslop, LA; Blakeley, P; Craven, L; Richardson, J; Fogarty, NME; Fragouli, E; Lamb, M; Wamaitha, SE; Prathalingam, N; Zhang, Q; O'Keefe, H; Takeda, Y; Arizzi, L; Alfarawati, S; Tuppen, HA; Irving, L; Kalleas, D; Choudhary, M; Wells, D; Murdoch, AP; Turnbull, DM; Niakan, KK and Herbert, M (2016)
    Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
    Nature 534, 383-386 PubMed abstract
  • Shahbazi, MN; Jedrusik, A; Vuoristo, S; Recher, G; Hupalowska, A; Bolton, V; Fogarty, NME; Campbell, A; Devito, LG; Ilic, D; Khalaf, Y; Niakan, KK; Fishel, S and Zernicka-Goetz, M (2016)
    Self-organization of the human embryo in the absence of maternal tissues.
    Nature Cell Biology 18, 700-708 PubMed abstract
  • Blakeley, P; Fogarty, NME; del Valle, I; Wamaitha, SE; Hu, TX; Elder, K; Snell, P; Christie, L; Robson, P and Niakan, KK (2015)
    Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.
    Development 142, 3151-3165 PubMed abstract
  • Fogarty, NME; Burton, GJ and Ferguson-Smith, AC (2015)
    Different epigenetic states define syncytiotrophoblast and cytotrophoblast nuclei in the trophoblast of the human placenta.
    Placenta 36, 796-802 PubMed abstract
  • Mulvey, CM; Schröter, C; Gatto, L; Dikicioglu, D; Baris Fidaner, I; Christoforou, A; Deery, MJ; Cho, LTY; Niakan, KK; Martinez-Arias, A and Lilley, KS (2015)
    Dynamic proteomic profiling of extra-embryonic endoderm differentiation in mouse embryonic stem cells.
    Stem Cells 33, 2712-2725 PubMed abstract
  • Wamaitha, SE; Del Valle, I; Cho, LTY; Wei, Y; Fogarty, NME; Blakeley, P; Sherwood, RI; Ji, H and Niakan, KK (2015)
    Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells.
    Genes & Development 29, 1239-1255 PubMed abstract
  • Niakan, KK and Eggan, K (2013)
    Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse.
    Developmental Biology 375, 54-64 PubMed abstract
  • Niakan, KK; Schrode, N; Cho, LTY and Hadjantonakis, A-K (2013)
    Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells.
    Nature Protocols 8, 1028-1041 PubMed abstract
  • Cho, LTY; Wamaitha, SE; Tsai, IJ; Artus, J; Sherwood, RI; Pedersen, RA; Hadjantonakis, A-K and Niakan, KK (2012)
    Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states.
    Development 139, 2866-2877 PubMed abstract
  • Krueger, C; King, MR; Krueger, F; Branco, MR; Osborne, CS; Niakan, KK; Higgins, MJ and Reik, W (2012)
    Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.
    PLOS ONE 7, e38983 PubMed abstract
  • Niakan, KK; Han, J; Pedersen, RA; Simon, C and Pera, RAR (2012)
    Human pre-implantation embryo development.
    Development 139, 829-841 PubMed abstract
  • Bernardo, AS; Faial, T; Gardner, L; Niakan, KK; Ortmann, D; Senner, CE; Callery, EM; Trotter, MW; Hemberger, M; Smith, JC; Bardwell, L; Moffett, A and Pedersen, RA (2011)
    BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
    Cell Stem Cell 9, 144-155 PubMed abstract
  • Niakan, KK; Ji, H; Maehr, R; Vokes, SA; Rodolfa, KT; Sherwood, RI; Yamaki, M; Dimos, JT; Chen, AE; Melton, DA; McMahon, AP and Eggan, K (2010)
    Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
    Genes & Development 24, 312-326 PubMed abstract

[Page last updated 1 Jun 2018]

Kathy Niakan

+44 (0)20 379 61539

  • Qualifications and History
  • 2005 PhD, University of California, Los Angeles, USA
  • 2005 Postdoctoral Fellow, Harvard University, Cambridge, USA
  • 2009 Centre for Trophoblast Research Next Generation Fellow, University of Cambridge, UK
  • 2013 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK