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Breadcrumb Vivian Li Li lab Stem Cell and Cancer Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Lab news Vacancies Intestinal stem cell culture (organoids) labelled with markers of dividing stem cells (green), matured cells (red) and cell nuclei (blue). Toggle to view hero caption PublicationsYear published2024 (1)2023 (3)2022 (2)2021 (5)2020 (7)2019 (6)2018 (4)2017 (4)2016 (1)2015 (4)2014 (1)2013 (3)2012 (4)2011 (2)2010 (2) Facet Year publishedResearch topicsDevelopmental Biology (32)Human Biology & Physiology (32)Signalling & Oncogenes (32)Stem Cells (32)Tumour Biology (32)Computational & Systems Biology (9)Biochemistry & Proteomics (6)Cell Biology (6)Chemical Biology & High Throughput (6)Metabolism (5)Model Organisms (5)Infectious Disease (4)Genome Integrity & Repair (3)Immunology (3)Genetics & Genomics (2)Imaging (1)Structural Biology & Biophysics (1)Synthetic Biology (1) Facet Research topicsCrick/Pre-CrickCrick publications (33)Pre-Crick publications (12) Facet Crick/Pre-CrickPublication typeJournal article (45)Primary research (24)Review (7)Commentary (2)Method (1) Facet Publication typeJournalCell (3)Cell Reports (3)Nature Communications (3)The EMBO Journal (3)Gastroenterology (2)Nature (2)Nature Medicine (2)Nature Metabolism (2)Nature Reviews Gastroenterology and Hepatology (2)Proceedings of the National Academy of Sciences of the United States of America (2)American Journal of Physiology. Cell Physiology (1)American Journal of Physiology: Cell Physiology (1)Biological Chemistry (1)Cell Stem Cell (1)Cellular oncology (Dordrecht) (1)Current Biology (1)Development (1)EMBO Journal (1)Immunity (1)Molecular and Cellular Biology (1)Mucosal Immunology (1)Nature Cell Biology (1)Nature Genetics (1)Nature Methods (1)Nature Protocols (1)New Scientist (1)PLOS Biology (1)PLOS ONE (1)Proceedings of the National Academy of Sciences of USA (1)Stem Cell Reports (1)Stem Cells International (1) Facet Journal Publications Displaying 1 - 20 of 49Last updated : 28 March 2024 03:39 Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids Authors (27) Mattia Francesco Maria Gerli Giuseppe Calà Max Arran Beesley Beatrice SinaLucinda Tullie Kylin Yunyan Sun[...] Davide Cacchiarelli Jan DeprestVivian Li Giovanni Giuseppe Giobbe Paolo De Coppi Nature Medicine Published 4 March 2024 Crick labsVivian LiFull details Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target Authors (54) Johan Vande Voorde Rory T Steven Arafath K Najumudeen Catriona A Ford Alex Dexter Ariadna Gonzalez-Fernandez[...] David Sumpton Zoltan Takats Andrew D Campbell Josephine Bunch Owen J Sansom Nature Metabolism Published 1 August 2023 Crick labs/ facilitiesMariia YunevaVivian LiExperimental HistopathologyBiological Research FacilityFull details USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development Authors (11)Laura NovellasdemuntAnia KucharskaAnna Baulies DomenechColin Hutton Georgios VlachogiannisDimitra RepanaAndrew Rowan A Suárez-BonnetFrancesca Ciccarelli Nicola ValeriVivian Li Stem Cell Reports Published 14 February 2023 Crick labs/ facilitiesCharles SwantonVivian LiFrancesca CiccarelliExperimental HistopathologyBiological Research FacilityFull details Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds Authors (5)Laween MeranLucinda Tullie Simon Eaton Paolo De CoppiVivian Li Nature Protocols Published 1 January 2023 Crick labs/ facilitiesVivian LiExperimental HistopathologyFull details ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle Authors (32) Cathrine Nordgaard Anna Constance Vind Amy Stonadge Rasmus Kjøbsted Goda SnieckutePedro Da Costa Antas[...]Vivian Li Sara A Wickström Jesper Velgaard Olsen Gonzalo Blanco Simon Bekker-Jensen The EMBO Journal Published 28 July 2022 Crick labsVivian LiFull details Building gut from scratch - progress and update of intestinal tissue engineering Authors (4)Lucinda Tullie Brendan C Jones Paolo De CoppiVivian Li Nature Reviews Gastroenterology and Hepatology Published 1 July 2022 Crick labsVivian LiFull details SARS-CoV-2 infection and replication in human gastric organoids Authors (25) Giovanni Giuseppe Giobbe Francesco Bonfante Brendan C Jones Onelia Gagliano Camilla Luni Elisa Zambaiti[...] Simon Eaton Davide Cacchiarelli Hans Clevers Nicola Elvassore Paolo De Coppi Nature Communications Published 16 November 2021 Crick labsVivian LiFull details Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway Authors (10) Abril Sánchez-Botet Eva Quandt Núria Masip Rubén EscribáLaura Novellasdemunt Laura GasaVivian Li Ángel Raya Josep Clotet Mariana PC Ribeiro Cellular oncology (Dordrecht) Published 1 December 2021 Crick labsVivian LiFull details Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration Authors (12)Oriane GuillerminNikos AngelisClara Sidor Rachel RidgwayAnna Baulies DomenechAnia Kucharska[...] Melissa R Rose Julia Cordero Owen SansomVivian Li Barry J Thompson The EMBO Journal Published 1 July 2021 Crick labsBarry ThompsonVivian LiFull details Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy Authors (23)Mylene TajanMarc HennequartEric CheungFabio Zani Andreas K HockNathalie Legrave[...] Adam Friedman Mark Manfredi Karen Blyth Owen J SansomKaren Vousden Nature Communications Published 14 January 2021 Crick labs/ facilitiesKaren VousdenVivian LiMetabolomicsExperimental HistopathologyBiological Research FacilityFull details Modelling intestinal inflammation and infection using 'mini-gut' organoids Authors (1)Vivian Li Nature Reviews Gastroenterology and Hepatology Published 1 February 2021 Crick labsVivian LiFull details Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation Authors (27) Marjoke F DebetsOmur Yilmaz Tastan Simon P Wisnovsky Stacy A MalakerNikos Angelis Leonhard KR Moeckl[...] Michael C Bassik WE MoernerVivian Li Carolyn R BertozziBen Schumann Proceedings of the National Academy of Sciences of USA Published 13 October 2020 Crick labs/ facilitiesBen SchumannNeil McDonaldVivian LiLuiz Pedro CarvalhoStructural BiologyProteomicsCell ServicesFull details Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure Authors (25)Laween MeranIsobel MassieSara CampinotiAnne Weston Riana GaifulinaLucinda Tullie[...] Geraint MH Thomas Simon EatonPaola Bonfanti Paolo De CoppiVivian Li Nature Medicine Published 1 October 2020 Crick labs/ facilitiesVivian LiPaola BonfantiProteomicsElectron MicroscopyIn Vivo ImagingExperimental HistopathologyBiological Research FacilityFull details Hallmarks of intestinal stem cells Authors (3)Anna Baulies DomenechNikos AngelisVivian Li Development Published 3 August 2020 Crick labsVivian LiFull details The transcription co-repressors MTG8 and MTG16 regulate exit of intestinal stem cells from their niche and differentiation into enterocyte vs secretory lineages Authors (11)Anna Baulies DomenechNikos Angelis Valentina FoglizzoErik Danielsen Harshil PatelLaura NovellasdemuntAnia KucharskaJoana Do Vale Viegas Silva CarvalhoEmma Nye Paolo De CoppiVivian Li Gastroenterology Published 1 October 2020 Crick labs/ facilitiesVivian LiExperimental HistopathologyBioinformatics and BiostatisticsFull details A brief history of organoids Authors (3)Claudia CorroLaura NovellasdemuntVivian Li American Journal of Physiology: Cell Physiology Published 1 July 2020 Crick labsVivian LiFull details Identifying strategies to target the metabolic flexibility of tumours Authors (16)Andres Mendez-LucasWei LinPaul DriscollNathalie LegraveLaura Novellasdemunt Chencheng Xie[...]Vivian LiJames Macrae Nissim Hay Xin ChenMariia Yuneva Nature Metabolism Published 1 April 2020 Crick labs/ facilitiesMariia YunevaVivian LiMetabolomicsMRC Biomedical NMR CentreBiological Research FacilityFull details Cell-type-specific signaling networks in heterocellular organoids Authors (8) Xiao Qin Jahangir Sufi Petra Vlckova Pelagia Kyriakidou Sophie E ActonVivian Li Mark Nitz Christopher J Tape Nature Methods Published 1 March 2020 Crick labsVivian LiFull details NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor Authors (10)Laura NovellasdemuntAnia Kucharska Cara Jamieson Maria Prange-BarczynskaAnna Baulies Domenech Pedro Antas Jelte van der Vaart Helmuth Gehart Madelon M MauriceVivian Li The EMBO Journal Published 23 December 2019 Crick labs/ facilitiesVivian LiFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture Authors (22) Giovanni Giuseppe Giobbe Claire Crowley Camilla LuniSara CampinotiMoustafa Khedr Kai Kretzschmar[...]Vivian Li Hans CleversPaola Bonfanti Nicola Elvassore Paolo De Coppi Nature Communications Published 11 December 2019 Crick labsVivian LiPaola BonfantiFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids Authors (27) Mattia Francesco Maria Gerli Giuseppe Calà Max Arran Beesley Beatrice SinaLucinda Tullie Kylin Yunyan Sun[...] Davide Cacchiarelli Jan DeprestVivian Li Giovanni Giuseppe Giobbe Paolo De Coppi Nature Medicine Published 4 March 2024 Crick labsVivian LiFull details
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target Authors (54) Johan Vande Voorde Rory T Steven Arafath K Najumudeen Catriona A Ford Alex Dexter Ariadna Gonzalez-Fernandez[...] David Sumpton Zoltan Takats Andrew D Campbell Josephine Bunch Owen J Sansom Nature Metabolism Published 1 August 2023 Crick labs/ facilitiesMariia YunevaVivian LiExperimental HistopathologyBiological Research FacilityFull details
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development Authors (11)Laura NovellasdemuntAnia KucharskaAnna Baulies DomenechColin Hutton Georgios VlachogiannisDimitra RepanaAndrew Rowan A Suárez-BonnetFrancesca Ciccarelli Nicola ValeriVivian Li Stem Cell Reports Published 14 February 2023 Crick labs/ facilitiesCharles SwantonVivian LiFrancesca CiccarelliExperimental HistopathologyBiological Research FacilityFull details
Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds Authors (5)Laween MeranLucinda Tullie Simon Eaton Paolo De CoppiVivian Li Nature Protocols Published 1 January 2023 Crick labs/ facilitiesVivian LiExperimental HistopathologyFull details
ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle Authors (32) Cathrine Nordgaard Anna Constance Vind Amy Stonadge Rasmus Kjøbsted Goda SnieckutePedro Da Costa Antas[...]Vivian Li Sara A Wickström Jesper Velgaard Olsen Gonzalo Blanco Simon Bekker-Jensen The EMBO Journal Published 28 July 2022 Crick labsVivian LiFull details
Building gut from scratch - progress and update of intestinal tissue engineering Authors (4)Lucinda Tullie Brendan C Jones Paolo De CoppiVivian Li Nature Reviews Gastroenterology and Hepatology Published 1 July 2022 Crick labsVivian LiFull details
SARS-CoV-2 infection and replication in human gastric organoids Authors (25) Giovanni Giuseppe Giobbe Francesco Bonfante Brendan C Jones Onelia Gagliano Camilla Luni Elisa Zambaiti[...] Simon Eaton Davide Cacchiarelli Hans Clevers Nicola Elvassore Paolo De Coppi Nature Communications Published 16 November 2021 Crick labsVivian LiFull details
Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway Authors (10) Abril Sánchez-Botet Eva Quandt Núria Masip Rubén EscribáLaura Novellasdemunt Laura GasaVivian Li Ángel Raya Josep Clotet Mariana PC Ribeiro Cellular oncology (Dordrecht) Published 1 December 2021 Crick labsVivian LiFull details
Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration Authors (12)Oriane GuillerminNikos AngelisClara Sidor Rachel RidgwayAnna Baulies DomenechAnia Kucharska[...] Melissa R Rose Julia Cordero Owen SansomVivian Li Barry J Thompson The EMBO Journal Published 1 July 2021 Crick labsBarry ThompsonVivian LiFull details
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy Authors (23)Mylene TajanMarc HennequartEric CheungFabio Zani Andreas K HockNathalie Legrave[...] Adam Friedman Mark Manfredi Karen Blyth Owen J SansomKaren Vousden Nature Communications Published 14 January 2021 Crick labs/ facilitiesKaren VousdenVivian LiMetabolomicsExperimental HistopathologyBiological Research FacilityFull details
Modelling intestinal inflammation and infection using 'mini-gut' organoids Authors (1)Vivian Li Nature Reviews Gastroenterology and Hepatology Published 1 February 2021 Crick labsVivian LiFull details
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation Authors (27) Marjoke F DebetsOmur Yilmaz Tastan Simon P Wisnovsky Stacy A MalakerNikos Angelis Leonhard KR Moeckl[...] Michael C Bassik WE MoernerVivian Li Carolyn R BertozziBen Schumann Proceedings of the National Academy of Sciences of USA Published 13 October 2020 Crick labs/ facilitiesBen SchumannNeil McDonaldVivian LiLuiz Pedro CarvalhoStructural BiologyProteomicsCell ServicesFull details
Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure Authors (25)Laween MeranIsobel MassieSara CampinotiAnne Weston Riana GaifulinaLucinda Tullie[...] Geraint MH Thomas Simon EatonPaola Bonfanti Paolo De CoppiVivian Li Nature Medicine Published 1 October 2020 Crick labs/ facilitiesVivian LiPaola BonfantiProteomicsElectron MicroscopyIn Vivo ImagingExperimental HistopathologyBiological Research FacilityFull details
Hallmarks of intestinal stem cells Authors (3)Anna Baulies DomenechNikos AngelisVivian Li Development Published 3 August 2020 Crick labsVivian LiFull details
The transcription co-repressors MTG8 and MTG16 regulate exit of intestinal stem cells from their niche and differentiation into enterocyte vs secretory lineages Authors (11)Anna Baulies DomenechNikos Angelis Valentina FoglizzoErik Danielsen Harshil PatelLaura NovellasdemuntAnia KucharskaJoana Do Vale Viegas Silva CarvalhoEmma Nye Paolo De CoppiVivian Li Gastroenterology Published 1 October 2020 Crick labs/ facilitiesVivian LiExperimental HistopathologyBioinformatics and BiostatisticsFull details
A brief history of organoids Authors (3)Claudia CorroLaura NovellasdemuntVivian Li American Journal of Physiology: Cell Physiology Published 1 July 2020 Crick labsVivian LiFull details
Identifying strategies to target the metabolic flexibility of tumours Authors (16)Andres Mendez-LucasWei LinPaul DriscollNathalie LegraveLaura Novellasdemunt Chencheng Xie[...]Vivian LiJames Macrae Nissim Hay Xin ChenMariia Yuneva Nature Metabolism Published 1 April 2020 Crick labs/ facilitiesMariia YunevaVivian LiMetabolomicsMRC Biomedical NMR CentreBiological Research FacilityFull details
Cell-type-specific signaling networks in heterocellular organoids Authors (8) Xiao Qin Jahangir Sufi Petra Vlckova Pelagia Kyriakidou Sophie E ActonVivian Li Mark Nitz Christopher J Tape Nature Methods Published 1 March 2020 Crick labsVivian LiFull details
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor Authors (10)Laura NovellasdemuntAnia Kucharska Cara Jamieson Maria Prange-BarczynskaAnna Baulies Domenech Pedro Antas Jelte van der Vaart Helmuth Gehart Madelon M MauriceVivian Li The EMBO Journal Published 23 December 2019 Crick labs/ facilitiesVivian LiFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture Authors (22) Giovanni Giuseppe Giobbe Claire Crowley Camilla LuniSara CampinotiMoustafa Khedr Kai Kretzschmar[...]Vivian Li Hans CleversPaola Bonfanti Nicola Elvassore Paolo De Coppi Nature Communications Published 11 December 2019 Crick labsVivian LiPaola BonfantiFull details