Caetano Reis e Sousa: Publications

  • Reis e Sousa, C (2017)
    Sensing infection and tissue damage.
    EMBO Molecular Medicine 9, 285-288 PubMed abstract
  • Acton, SE and Reis e Sousa, C (2016)
    Dendritic cells in remodeling of lymph nodes during immune responses.
    Immunological Reviews 271, 221-229 PubMed abstract
  • Hanč, P; Schulz, O; Fischbach, H; Martin, SR; Kjær, S and Reis e Sousa, C (2016)
    A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.
    EMBO Journal 35, 2484-2497 PubMed abstract
  • Helft, J; Böttcher, JP; Chakravarty, P; Zelenay, S; Huotari, J; Schraml, BU; Goubau, D and Reis e Sousa, C (2016)
    Alive but confused: heterogeneity of CD11c+ MHC class II+ cells in GM-CSF mouse bone marrow cultures.
    Immunity 44, 3-4 PubMed abstract
  • Maillard, PV; Van der Veen, AG; Deddouche-Grass, S; Rogers, NC; Merits, A and Reis e Sousa, C (2016)
    Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.
    EMBO Journal 35, 2505-2518 PubMed abstract
  • Schraml, B; van Blijswijk, J; Snelgrove, K; Rogers, N and Reis e Sousa, C (2016)
    Developmental heterogeneity of splenic CD11b+ dendritic cells.
    European Journal of Immunology 46, 821, Abstract no.1428
  • Silva-Santos, B; Di Santo, J and Reis e Sousa, C (2016)
    Immunology's Twinning Triangle.
    European Journal of Immunology 46, 2283-2285 PubMed abstract
  • Srinivasan, N; Gordon, O; Ahrens, S; Franz, A; Deddouche, S; Chakravarty, P; Phillips, D; Yunus, AA; Rosen, MK; Valente, RS; Teixeira, L; Thompson, B; Dionne, MS; Wood, W and Reis e Sousa, C (2016)
    Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster.
    eLife 5, e19662 PubMed abstract
  • Zelenay, S and Reis e Sousa, C (2016)
    Reducing prostaglandin E2 production to raise cancer immunogenicity.
    Oncoimmunology 5, e1123370 PubMed abstract
  • Böttcher, JP; Zelenay, S; Rogers, NC; Helft, J; Schraml, BU and Reis e Sousa, C (2015)
    Oncogenic transformation of dendritic cells and their precursors leads to rapid cancer development in mice.
    Journal of Immunology 195, 5066-5076 PubMed abstract
  • Gaya, M; Castello, A; Montaner, B; Rogers, N; Reis e Sousa, C; Bruckbauer, A and Batista, FD (2015)
    Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection.
    Science 347, 667-672 PubMed abstract
  • Goubau, D; van der Veen, AG; Chakravarty, P; Lin, R; Rogers, N; Rehwinkel, J; Deddouche, S; Rosewell, I; Hiscott, J and Reis e Sousa, C (2015)
    Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.
    European Journal of Immunology 45, 3386-3403 PubMed abstract
  • Hanč, P; Fujii, T; Iborra, S; Yamada, Y; Huotari, J; Schulz, O; Ahrens, S; Kjær, S; Way, M; Sancho, D; Namba, K and Reis e Sousa, C (2015)
    Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens.
    Immunity 42, 839-849 PubMed abstract
  • Helft, J; Böttcher, J; Chakravarty, P; Zelenay, S; Huotari, J; Schraml, BU; Goubau, D and Reis e Sousa, C (2015)
    GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+MHCII+ macrophages and dendritic cells.
    Immunity 42, 1197-1211 PubMed abstract
  • Hipp, MM; Shepherd, D; Booth, S; Waithe, D; Reis e Sousa, C and Cerundolo, V (2015)
    The processed amino-terminal fragment of human TLR7 acts as a chaperone to direct human TLR7 into endosomes.
    Journal of Immunology 194, 5417-5425 PubMed abstract
  • Reis e Sousa, C (2015)
    Dendritic cells in immunity to infection and cancer.
    Cytokine 76, 58-59, Meeting Abstract 59
  • Schraml, BU and Reis e Sousa, C (2015)
    Defining dendritic cells.
    Current Opinion in Immunology 32, 13-20 PubMed abstract
  • Swamy, M; Abeler-Dörner, L; Chettle, J; Mahlakõiv, T; Goubau, D; Chakravarty, P; Ramsay, G; Reis e Sousa, C; Staeheli, P; Blacklaws, BA; Heeney, JL and Hayday, AC (2015)
    Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.
    Nature Communications 6, 7090 PubMed abstract
  • van Blijswijk, J; Schraml, BU; Rogers, NC; Whitney, PG; Zelenay, S; Acton, SE and Reis e Sousa, C (2015)
    Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells.
    Journal of Immunology 194, 307-315 PubMed abstract
  • van der Veen, AG; Maillard, PV and Reis e Sousa, C (2015)
    Drosha cuts the tethers of myelopoiesis.
    Nature Immunology 16, 1110-1112 PubMed abstract
  • Yatim, N; Jusforgues-Saklani, H; Orozco, S; Schulz, O; Barreira da Silva, R; Reis e Sousa, C; Green, DR; Oberst, A and Albert, ML (2015)
    RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells.
    Science 350, 328-334 PubMed abstract
  • Zelenay, S; van der Veen, AG; Böttcher, JP; Snelgrove, KJ; Rogers, N; Acton, SE; Chakravarty, P; Girotti, MR; Marais, R; Quezada, SA; Sahai, E and Reis e Sousa, C (2015)
    Cyclooxygenase-dependent tumor growth through evasion of immunity.
    Cell 162, 1257-1270 PubMed abstract
  • Acton, SE; Farrugia, AJ; Astarita, JL; Mourão-Sá, D; Jenkins, RP; Nye, E; Hooper, S; van Blijswijk, J; Rogers, NC; Snelgrove, KJ; Rosewell, I; Moita, LF; Stamp, G; Turley, SJ; Sahai, E and Reis e Sousa, C (2014)
    Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
    Nature 514, 498-502 PubMed abstract
  • Bär, E; Whitney, PG; Moor, K; Reis e Sousa, C and LeibundGut-Landmann, S (2014)
    IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells.
    Immunity 40, 117-127 PubMed abstract
  • Deddouche, S; Goubau, D; Rehwinkel, J; Chakravarty, P; Begum, S; Maillard, PV; Borg, A; Matthews, N; Feng, Q; van Kuppeveld, FJM and Reis e Sousa, C (2014)
    Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
    eLife 3, e01535 PubMed abstract
  • Goubau, D; Schlee, M; Deddouche, S; Pruijssers, AJ; Zillinger, T; Goldeck, M; Schuberth, C; Van der Veen, AG; Fujimura, T; Rehwinkel, J; Iskarpatyoti, JA; Barchet, W; Ludwig, J; Dermody, TS; Hartmann, G and Reis e Sousa, C (2014)
    Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
    Nature 514, 372-375 PubMed abstract
  • Li, J; Ahmet, F; Sullivan, LC; Brooks, AG; Kent, SJ; De Rose, R; Salazar, AM; Reis e Sousa, C; Shortman, K; Lahoud, MH; Heath, WR and Caminschi, I (2014)
    Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.
    European Journal of Immunology 45, 854-864 PubMed abstract
  • Reis e Sousa, C and Unanue, ER (2014)
    Antigen processing.
    Current Opinion in Immunology 26, 138-139 PubMed abstract
  • Whitney, PG; Bär, E; Osorio, F; Rogers, NC; Schraml, BU; Deddouche, S; LeibundGut-Landmann, S and Reis e Sousa, C (2014)
    Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.
    PLOS Pathogens 10, e1004276 PubMed abstract
  • Goubau, D; Deddouche, S and Reis e Sousa, C (2013)
    Cytosolic sensing of viruses.
    Immunity 38, 855-869 PubMed abstract
  • Hipp, MM; Shepherd, D; Gileadi, U; Aichinger, MC; Kessler, BM; Edelmann, MJ; Essalmani, R; Seidah, NG; Reis e Sousa, C and Cerundolo, V (2013)
    Processing of human Toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes.
    Immunity 39, 711-721 PubMed abstract
  • Rehwinkel, J; Maelfait, J; Bridgeman, A; Rigby, R; Hayward, B; Liberatore, RA; Bieniasz, PD; Towers, GJ; Moita, LF; Crow, YJ; Bonthron, DT and Reis e Sousa, C (2013)
    SAMHD1-dependent retroviral control and escape in mice.
    EMBO Journal 32, 2454-2462 PubMed abstract
  • Rehwinkel, J and Reis e Sousa, C (2013)
    Targeting the viral Achilles' heel: recognition of 5ʹ-triphosphate RNA in innate anti-viral defence.
    Current Opinion in Microbiology 16, 485-492 PubMed abstract
  • Sancho, D and Reis e Sousa, C (2013)
    Sensing of cell death by myeloid C-type lectin receptors.
    Current Opinion in Immunology 25, 46-52 PubMed abstract
  • Schraml, BU; van Blijswijk, J; Zelenay, S; Whitney, PG; Filby, A; Acton, SE; Rogers, NC; Moncaut, N; Carvajal, JJ and Reis e Sousa, C (2013)
    Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage.
    Cell 154, 843-858 PubMed abstract
  • van Blijswijk, J; Schraml, BU and Reis e Sousa, C (2013)
    Advantages and limitations of mouse models to deplete dendritic cells.
    European Journal of Immunology 43, 22-26 PubMed abstract
  • Zelenay, S and Reis e Sousa, C (2013)
    Adaptive immunity after cell death.
    Trends in Immunology 34, 329-335 PubMed abstract
  • Ahrens, S; Zelenay, S; Sancho, D; Hanč, P; Kjær, S; Feest, C; Fletcher, G; Durkin, C; Postigo, A; Skehel, M; Batista, F; Thompson, B; Way, M; Reis e Sousa, C and Schulz, O (2012)
    F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.
    Immunity 36, 635-645 PubMed abstract
  • Finney, BA; Schweighoffer, E; Navarro-Núñez, L; Bénézech, C; Barone, F; Hughes, CE; Langan, SA; Lowe, KL; Pollitt, AY; Mourao-Sa, D; Sheardown, S; Nash, GB; Smithers, N; Reis e Sousa, C; Tybulewicz, VLJ and Watson, SP (2012)
    CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
    Blood 119, 1747-1756 PubMed abstract
  • Iborra, S; Izquierdo, HM; Martínez-López, M; Blanco-Menéndez, N; Reis e Sousa, C and Sancho, D (2012)
    The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice.
    Journal of Clinical Investigation 122, 1628-1643 PubMed abstract
  • Poulin, LF; Reyal, Y; Uronen-Hansson, H; Schraml, BU; Sancho, D; Murphy, KM; Håkansson, UK; Moita, LF; Agace, WW; Bonnet, D and Reis e Sousa, C (2012)
    DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.
    Blood 119, 6052-6062 PubMed abstract
  • Sancho, D and Reis e Sousa, C (2012)
    Signaling by myeloid C-type lectin receptors in immunity and homeostasis.
    Annual Review of Immunology 30, 491-529 PubMed abstract
  • Tamoutounour, S; Henri, S; Lelouard, H; de Bovis, B; de Haar, C; van der Woude, CJ; Woltman, AM; Reyal, Y; Bonnet, D; Sichien, D; Bain, CC; Mowat, AM; Reis e Sousa, C; Poulin, LF; Malissen, B and Guilliams, M (2012)
    CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.
    European Journal of Immunology 42, 3150-3166 PubMed abstract
  • Zelenay, S; Keller, AM; Whitney, PG; Schraml, BU; Deddouche, S; Rogers, NC; Schulz, O; Sancho, D and Reis e Sousa, C (2012)
    The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice.
    Journal of Clinical Investigation 122, 1615-1627 PubMed abstract
  • Kool, M; Willart, MAM; van Nimwegen, M; Bergen, I; Pouliot, P; Virchow, JC; Rogers, N; Osorio, F; Reis e Sousa, C; Hammad, H and Lambrecht, BN (2011)
    An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.
    Immunity 34, 527-540 PubMed abstract
  • Kratky, W; Reis e Sousa, C; Oxenius, A and Spörri, R (2011)
    Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination.
    Proceedings of the National Academy of Sciences of the United States of America 108, 17414-17419 PubMed abstract
  • Mourão-Sá, D; Robinson, MJ; Zelenay, S; Sancho, D; Chakravarty, P; Larsen, R; Plantinga, M; Van Rooijen, N; Soares, MP; Lambrecht, B and Reis e Sousa, C (2011)
    CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses.
    European Journal of Immunology 41, 3040-3053 PubMed abstract
  • Osorio, F and Reis e Sousa, C (2011)
    Myeloid C-type lectin receptors in pathogen recognition and host defense.
    Immunity 34, 651-664 PubMed abstract
  • Reis e Sousa, C (2011)
    2011 ESCI Award for Excellence in Basic/Translational Research: innate regulation of adaptive immunity by dendritic cells.
    European Journal of Clinical Investigation 41, 907-916 PubMed abstract
  • Reis e Sousa, C (2011)
    Harnessing dendritic cells.
    Seminars in Immunology 23, 1 PubMed abstract
  • Rosas, M; Osorio, F; Robinson, MJ; Davies, LC; Dierkes, N; Jones, SA; Reis e Sousa, C and Taylor, PR (2011)
    Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells.
    European Journal of Immunology 41, 356-365 PubMed abstract
  • Goubau, D; Rehwinkel, J and Reis e Sousa, C (2010)
    PYHIN proteins: center stage in DNA sensing.
    Nature Immunology 11, 984-986 PubMed abstract
  • Joffre, OP; Sancho, D; Zelenay, S; Keller, AM and Reis e Sousa, C (2010)
    Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
    European Journal of Immunology 40, 1255-1265 PubMed abstract
  • Poulin, LF; Salio, M; Griessinger, E; Anjos-Afonso, F; Craciun, L; Chen, J-L; Keller, AM; Joffre, O; Zelenay, S; Nye, E; Le Moine, A; Faure, F; Donckier, V; Sancho, D; Cerundolo, V; Bonnet, D and Reis e Sousa, C (2010)
    Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells.
    Journal of Experimental Medicine 207, 1261-1271 PubMed abstract
  • Rehwinkel, J and Reis e Sousa, C (2010)
    RIGorous detection: exposing virus through RNA sensing.
    Science 327, 284-286 PubMed abstract
  • Rehwinkel, J; Tan, CP; Goubau, D; Schulz, O; Pichlmair, A; Bier, K; Robb, N; Vreede, F; Barclay, W; Fodor, E and Reis e Sousa, C (2010)
    RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
    Cell 140, 397-408 PubMed abstract
  • Schulz, O; Pichlmair, A; Rehwinkel, J; Rogers, NC; Scheuner, D; Kato, H; Takeuchi, O; Akira, S; Kaufman, RJ and Reis e Sousa, C (2010)
    Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.
    Cell Host & Microbe 7, 354-361 PubMed abstract

[Page last updated 1 May 2017]

Caetano Reis e Sousa

caetano@crick.ac.uk
+44 (0) 20 7269 2832

  • Qualifications and history
  • 1992 DPhil, University of Oxford, UK
  • 1993 Visiting Fellow, National Institute of Allergy and Infectious Diseases, National Institute of Health, USA
  • 1998 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK