Charles Swanton: Publications

  • Abbosh, C; Birkbak, NJ; Wilson, GA; Jamal-Hanjani, M; Constantin, T; Salari, R; Quesne, JL; Moore, DA; Veeriah, S; Rosenthal, R; Marafioti, T; Kirkizlar, E; Watkins, TBK; McGranahan, N; Ward, S; Martinson, L; Riley, J; Fraioli, F; Bakir, MA; Grönroos, E; Zambrana, F; Endozo, R; Bi, WL; Fennessy, FM; Sponer, N; Johnson, D; Laycock, J; Shafi, S; Czyzewska-Khan, J; Rowan, A; Chambers, T; Matthews, N; Turajlic, S; Hiley, C; Lee, SM; Forster, MD; Ahmad, T; Falzon, M; Borg, E; Lawrence, D; Hayward, M; Kolvekar, S; Panagiotopoulos, N; Janes, SM; Thakrar, R; Ahmed, A; Blackhall, F; Summers, Y; Hafez, D; Naik, A; Ganguly, A; Kareht, S; Shah, R; Joseph, L; Quinn, AM; Crosbie, P; Naidu, B; Middleton, G; Langman, G; Trotter, S; Nicolson, M; Remmen, H; Kerr, K; Chetty, M; Gomersall, L; Fennell, DA; Nakas, A; Rathinam, S; Anand, G; Khan, S; Russell, P; Ezhil, V; Ismail, B; Irvin-sellers, M; Prakash, V; Lester, JF; Kornaszewska, M; Attanoos, R; Adams, H; Davies, H; Oukrif, D; Akarca, AU; Hartley, JA; Lowe, HL; Lock, S; Iles, N; Bell, H; Ngai, Y; Elgar, G; Szallasi, Z; Schwarz, RF; Herrero, J; Stewart, A; Quezada, SA; Van Loo, P; Dive, C; Lin, CJ; Rabinowitz, M; Aerts, HJWL; Hackshaw, A; Shaw, JA; Zimmermann, BG; The TRACERx Consortium; The PEACE Consortium and Swanton, C (2017)
    Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.
    Nature 545, 446-451 PubMed abstract
  • Amirouchene-Angelozzi, N; Swanton, C and Bardelli, A (2017)
    Tumor evolution as a therapeutic target.
    Cancer Discovery 7, 805-817 PubMed abstract
  • Arce Vargas, F; Furness, AJS; Solomon, I; Joshi, K; Mekkaoui, L; Lesko, MH; Miranda Rota, E; Dahan, R; Georgiou, A; Sledzinska, A; Ben Aissa, A; Franz, D; Werner Sunderland, M; Wong, YNS; Henry, JY; O'Brien, T; Nicol, D; Challacombe, B; Beers, SA; Melanoma TRACERx Consortium; Renal TRACERx Consortium; Lung TRACERx Consortium; Turajlic, S; Gore, M; Larkin, J; Swanton, C; Chester, KA; Pule, M; Ravetch, JV; Marafioti, T; Peggs, KS and Quezada, SA (2017)
    Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors.
    Immunity 46, 577-586 PubMed abstract
  • Barbieri, CE; Chinnaiyan, AM; Lerner, SP; Swanton, C and Rubin, MA (2017)
    The emergence of precision urologic oncology: a collaborative review on biomarker-driven therapeutics.
    European Urology 71, 237-246 PubMed abstract
  • Barrett, JE; Feber, A; Herrero, J; Tanic, M; Wilson, GA; Swanton, C and Beck, S (2017)
    Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection.
    BMC Bioinformatics 18, 354 PubMed abstract
  • Caswell, DR and Swanton, C (2017)
    The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome.
    BMC Medicine 15, 133 PubMed abstract
  • Crockford, A; Zalmas, LP; Grönroos, E; Dewhurst, SM; McGranahan, N; Cuomo, ME; Encheva, V; Snijders, AP; Begum, J; Purewal, S; Cerveira, J; Patel, H; Renshaw, MJ and Swanton, C (2017)
    Cyclin D mediates tolerance of genome-doubling in cancers with functional p53.
    Annals of Oncology 28, 149-156 PubMed abstract
  • Domingues, PH; Nanduri, LSY; Seget, K; Venkateswaran, SV; Agorku, D; Viganó, C; von Schubert, C; Nigg, EA; Swanton, C; Sotillo, R; Bosio, A; Storchová, Z and Hardt, O (2017)
    Cellular prion protein PrPC and ecto-5'-nucleotidase are markers of the cellular stress response to aneuploidy.
    Cancer Research 77, 2914-2926 PubMed abstract
  • Hsieh, JJ; Purdue, MP; Signoretti, S; Swanton, C; Albiges, L; Schmidinger, M; Heng, DY; Larkin, J and Ficarra, V (2017)
    Renal cell carcinoma.
    Nature Reviews Disease Primers 3, 17009 PubMed abstract
  • Hynds, RE and Janes, SM (2017)
    Airway basal cell heterogeneity and lung squamous cell carcinoma.
    Cancer Prevention Research [Epub ahead of print] PubMed abstract
  • Jamal-Hanjani, M; Wilson, GA; McGranahan, N; Birkbak, NJ; Watkins, TBK; Veeriah, S; Shafi, S; Johnson, DH; Mitter, R; Rosenthal, R; Salm, M; Horswell, S; Escudero, M; Matthews, N; Rowan, A; Chambers, T; Moore, DA; Turajlic, S; Xu, H; Lee, S-M; Forster, MD; Ahmad, T; Hiley, CT; Abbosh, C; Falzon, M; Borg, E; Marafioti, T; Lawrence, D; Hayward, M; Kolvekar, S; Panagiotopoulos, N; Janes, SM; Thakrar, R; Ahmed, A; Blackhall, F; Summers, Y; Shah, R; Joseph, L; Quinn, AM; Crosbie, PA; Naidu, B; Middleton, G; Langman, G; Trotter, S; Nicolson, M; Remmen, H; Kerr, K; Chetty, M; Gomersall, L; Fennell, DA; Nakas, A; Rathinam, S; Anand, G; Khan, S; Russell, P; Ezhil, V; Ismail, B; Irvin-Sellers, M; Prakash, V; Lester, JF; Kornaszewska, M; Attanoos, R; Adams, H; Davies, H; Dentro, S; Taniere, P; O'Sullivan, B; Lowe, HL; Hartley, JA; Iles, N; Bell, H; Ngai, Y; Shaw, JA; Herrero, J; Szallasi, Z; Schwarz, RF; Stewart, A; Quezada, SA; Le Quesne, J; Van Loo, P; Dive, C; Hackshaw, A; Swanton, C and The TRACERx Consortium (2017)
    Tracking the evolution of non-small-cell lung cancer.
    New England Journal of Medicine 376, 2109-2121 PubMed abstract
  • Litchfield, K; Turajlic, S and Swanton, C (2017)
    The GENIE is out of the bottle: landmark cancer genomics dataset released.
    Cancer Discovery 7, 796-798 PubMed abstract
  • López-Garcia, C; Sansregret, L; Domingo, E; McGranahan, N; Hobor, S; Birkbak, NJ; Horswell, S; Grönroos, E; Favero, F; Rowan, AJ; Matthews, N; Begum, S; Phillimore, B; Burrell, R; Oukrif, D; Spencer-Dene, B; Kovac, M; Stamp, G; Stewart, A; Danielsen, H; Novelli, M; Tomlinson, I and Swanton, C (2017)
    BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer.
    Cancer Cell 31, 79-93 PubMed abstract
  • McGranahan, N and Swanton, C (2017)
    Cancer evolution constrained by the immune microenvironment.
    Cell 170, 825-827 PubMed abstract
  • McGranahan, N and Swanton, C (2017)
    Clonal heterogeneity and tumor evolution: past, present, and the future.
    Cell 168, 613-628 PubMed abstract
  • Morrissy, AS; Cavalli, FMG; Remke, M; Ramaswamy, V; Shih, DJH; Holgado, BL; Farooq, H; Donovan, LK; Garzia, L; Agnihotri, S; Kiehna, EN; Mercier, E; Mayoh, C; Papillon-Cavanagh, S; Nikbakht, H; Gayden, T; Torchia, J; Picard, D; Merino, DM; Vladoiu, M; Luu, B; Wu, X; Daniels, C; Horswell, S; Thompson, YY; Hovestadt, V; Northcott, PA; Jones, DTW; Peacock, J; Wang, X; Mack, SC; Reimand, J; Albrecht, S; Fontebasso, AM; Thiessen, N; Li, Y; Schein, JE; Lee, D; Carlsen, R; Mayo, M; Tse, K; Tam, A; Dhalla, N; Ally, A; Chuah, E; Cheng, Y; Plettner, P; Li, HI; Corbett, RD; Wong, T; Long, W; Loukides, J; Buczkowicz, P; Hawkins, CE; Tabori, U; Rood, BR; Myseros, JS; Packer, RJ; Korshunov, A; Lichter, P; Kool, M; Pfister, SM; Schüller, U; Dirks, P; Huang, A; Bouffet, E; Rutka, JT; Bader, GD; Swanton, C; Ma, Y; Moore, RA; Mungall, AJ; Majewski, J; Jones, SJM; Das, S; Malkin, D; Jabado, N; Marra, MA and Taylor, MD (2017)
    Spatial heterogeneity in medulloblastoma.
    Nature Genetics 49, 780-788 PubMed abstract
  • Naxerova, K; Reiter, JG; Brachtel, E; Lennerz, JK; van de Wetering, M; Rowan, A; Cai, T; Clevers, H; Swanton, C; Nowak, MA; Elledge, SJ and Jain, RK (2017)
    Origins of lymphatic and distant metastases in human colorectal cancer.
    Science 357, 55-60 PubMed abstract
  • Qazi, MA; Vora, P; Venugopal, C; Sidhu, SS; Moffat, J; Swanton, C and Singh, SK (2017)
    Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma.
    Annals of Oncology 28, 1448-1456 PubMed abstract
  • Sahai, E; Swanton, C and Marshall Symposium (2017)
    Evolution and cancer medicine - transformative insights.
    Nature Reviews Clinical Oncology [Epub ahead of print] PubMed abstract
  • Sansregret, L; Patterson, JO; Dewhurst, S; López-García, C; Koch, A; McGranahan, N; Chao, WCH; Barry, DJ; Rowan, A; Instrell, R; Horswell, S; Way, M; Howell, M; Singleton, MR; Medema, RH; Nurse, P; Petronczki, M and Swanton, C (2017)
    APC/C dysfunction limits excessive cancer chromosomal instability.
    Cancer Discovery 7, 218-233 PubMed abstract
  • Sansregret, L and Swanton, C (2017)
    The role of aneuploidy in cancer evolution.
    Cold Spring Harbor Perspectives in Medicine 7, a028373 PubMed abstract
  • Spain, L; Walls, G; Messiou, C; Turajlic, S; Gore, M and Larkin, J (2017)
    Efficacy and toxicity of rechallenge with combination immune checkpoint blockade in metastatic melanoma: a case series.
    Cancer Immunology, Immunotherapy 66, 113-117 PubMed abstract
  • Téglási, V; Reiniger, L; Fábián, K; Pipek, O; Csala, I; Bagó, AG; Várallyai, P; Vízkeleti, L; Rojkó, L; Tímár, J; Döme, B; Szállási, Z; Swanton, C and Moldvay, J (2017)
    Evaluating the significance of density, localization, and PD-1/PD-L1 immunopositivity of mononuclear cells in the clinical course of lung adenocarcinoma patients with brain metastasis.
    Neuro-oncology 19, 1058-1067 PubMed abstract
  • Turajlic, S (2017)
    TRACERx Renal (TRAcking Renal Cell Carcinoma Evolution Through Therapy (Rx)).
    Journal of Pathology 241, S3
  • Turajlic, S; Litchfield, K; Xu, H; Rosenthal, R; McGranahan, N; Reading, JL; Wong, YNS; Rowan, A; Kanu, N; Al Bakir, M; Chambers, T; Salgado, R; Savas, P; Loi, S; Birkbak, NJ; Sansregret, L; Gore, M; Larkin, J; Quezada, SA and Swanton, C (2017)
    Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
    Lancet Oncology 18, 1009-1021 PubMed abstract
  • Turajlic, S and Swanton, C (2017)
    Implications of cancer evolution for drug development.
    Nature Reviews Drug Discovery 16, 441-442 PubMed abstract
  • Venkatesan, S; Birkbak, NJ and Swanton, C (2017)
    Constraints in cancer evolution.
    Biochemical Society Transactions 45, 1-13 PubMed abstract
  • Venkatesan, S; Swanton, C; Taylor, BS and Costello, JF (2017)
    Treatment-induced mutagenesis and selective pressures sculpt cancer evolution.
    Cold Spring Harbor Perspectives in Medicine 7, a026617 PubMed abstract
  • Watkins, TBK and Schwarz, RF (2017)
    Phylogenetic quantification of intratumor heterogeneity.
    Cold Spring Harbor Perspectives in Medicine [Epub ahead of print] PubMed abstract
  • Wong, YNS; Joshi, K; Pule, M; Peggs, KS; Swanton, C; Quezada, SA and Linch, M (2017)
    Evolving adoptive cellular therapies in urological malignancies.
    Lancet Oncology 18, e341-e353 PubMed abstract
  • Zámborszky, J; Szikriszt, B; Gervai, JZ; Pipek, O; Póti, Á; Krzystanek, M; Ribli, D; Szalai-Gindl, JM; Csabai, I; Szallasi, Z; Swanton, C; Richardson, AL and Szüts, D (2017)
    Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions.
    Oncogene 36, 746-755 PubMed abstract
  • Bentzen, AK; Marquard, AM; Lyngaa, R; Saini, SK; Ramskov, S; Donia, M; Such, L; Furness, AJS; McGranahan, N; Rosenthal, R; Straten, Pt; Szallasi, Z; Svane, IM; Swanton, C; Quezada, SA; Jakobsen, SN; Eklund, AC and Hadrup, SR (2016)
    Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes.
    Nature Biotechnology 34, 1037-1045 PubMed abstract
  • Birkbak, NJ and Andersen, JB (2016)
    Heterogeneity among liver cancer - a hurdle to optimizing therapy.
    Gastroenterology 150, 818-821 PubMed abstract
  • Burrell, RA and Swanton, C (2016)
    Re-evaluating clonal dominance in cancer evolution.
    Trends in Cancer 2, 263-276 PubMed abstract
  • Goh, G; Schmid, R; Guiver, K; Arpornwirat, W; Chitapanarux, I; Ganju, V; Im, S-A; Kim, S-B; Dechaphunkul, A; Maneechavakajorn, J; Spector, N; Yau, T; Afrit, M; Ahmed, SB; Johnston, SR; Gibson, N; Uttenreuther-Fischer, M; Herrero, J and Swanton, C (2016)
    Clonal evolutionary analysis during HER2 blockade in HER2-positive inflammatory breast cancer: a phase II open-label clinical trial of afatinib +/- vinorelbine.
    PLOS Medicine 13, e1002136 PubMed abstract
  • Hiley, CT; Le Quesne, J; Santis, G; Sharpe, R; de Castro, DG; Middleton, G and Swanton, C (2016)
    Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease.
    Lancet 388, 1002-1011 PubMed abstract
  • Hiley, CT and Swanton, C (2016)
    Pruning cancer's evolutionary tree with lesion-directed therapy.
    Cancer Discovery 6, 122-124 PubMed abstract
  • Jamal-Hanjani, M; Wilson, GA; Horswell, S; Mitter, R; Sakarya, O; Constantin, T; Salari, R; Kirkizlar, E; Sigurjonsson, S; Pelham, R; Kareht, S; Zimmermann, B and Swanton, C (2016)
    Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer.
    Annals of Oncology 27, 862-867 PubMed abstract
  • Kanu, N; Cerone, MA; Goh, G; Zalmas, L-P; Bartkova, J; Dietzen, M; McGranahan, N; Rogers, R; Law, EK; Gromova, I; Kschischo, M; Walton, MI; Rossanese, OW; Bartek, J; Harris, RS; Venkatesan, S and Swanton, C (2016)
    DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
    Genome Biology 17, 185 PubMed abstract
  • Klionsky, DJ; Abdelmohsen, K; ...; Gutierrez, MG; ...; Swanton, C; ... and Tooze, SA (2016)
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Autophagy 12, 1-222 PubMed abstract
  • McGranahan, N (2016)
    Deciphering cancer genome evolution in heterogenous tumors.
    Cancer Research 76, Abstract no.IA17
  • McGranahan, N; Furness, AJS; Rosenthal, R; Ramskov, S; Lyngaa, R; Saini, SK; Jamal-Hanjani, M; Wilson, GA; Birkbak, NJ; Hiley, CT; Watkins, TBK; Shafi, S; Murugaesu, N; Mitter, R; Akarca, AU; Linares, J; Marafioti, T; Henry, JY; Van Allen, EM; Miao, D; Schilling, B; Schadendorf, D; Garraway, LA; Makarov, V; Rizvi, NA; Snyder, A; Hellmann, MD; Merghoub, T; Wolchok, JD; Shukla, SA; Wu, CJ; Peggs, KS; Chan, TA; Hadrup, SR; Quezada, SA and Swanton, C (2016)
    Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
    Science 351, 1463-1469 PubMed abstract
  • Miller, RE; Brown, NF; Speirs, A; Shaw, HM; Adeleke, S; Gougis, P; Bennett, P; Meyer, T; Swanton, C; Forster, M and Kristeleit, RS (2016)
    The use of next generation sequencing (NGS) to guide patient selection for phase 1 clinical trials.
    Annals of Oncology 27, Abstract no. 401P
  • Moore, DA; Rehal, P; Swanton, C and Le Quesne, J (2016)
    The switch to invasiveness in lung adenocarcinoma.
    Lung Cancer 91, S4-S5, Abstract 11
  • Rosenthal, R; McGranahan, N; Herrero, J; Taylor, BS and Swanton, C (2016)
    deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution.
    Genome Biology 17, 31 PubMed abstract
  • Savas, P; Teo, ZL; Lefevre, C; Flensburg, C; Caramia, F; Alsop, K; Mansour, M; Francis, PA; Thorne, HA; Silva, MJ; Kanu, N; Dietzen, M; Rowan, A; Kschischo, M; Fox, S; Bowtell, DD; Dawson, S-J; Speed, TP; Swanton, C and Loi, S (2016)
    The subclonal architecture of metastatic breast cancer: results from a prospective community-based rapid autopsy program "CASCADE".
    PLOS Medicine 13, e1002204 PubMed abstract
  • Scelo, G; Hofmann, JN; Banks, RE; Bigot, P; Bhatt, RS; Cancel-Tassin, G; Chew, SK; Creighton, CJ; Cussenot, O; Davis, IJ; Escudier, B; Frayling, TM; Häggström, C; Hildebrandt, MAT; Holcatova, I; Johansson, M; Linehan, WM; McDermott, DF; Nathanson, KL; Ogawa, S; Perlman, EJ; Purdue, MP; Stattin, P; Swanton, C; Vasudev, NS; Wu, X; Znaor, A; Brennan, P and Chanock, SJ (2016)
    International cancer seminars: a focus on kidney cancer.
    Annals of Oncology 27, 1382-1385 PubMed abstract
  • Swanton, C; Boffetta, P; Peston, R and Soria, J-C (2016)
    Environmental emissions, public health and lung cancer risk.
    Annals of Oncology 27, 211-212 PubMed abstract
  • Swanton, C; Boffetta, P; Peston, R and Soria, J-C (2016)
    Reply to the letter to the editor 'Abandoning diesel because of health perspectives: are there reasonable alternatives?' by Vreugdenhil & Mannaerts.
    Annals of Oncology 27, 1361 PubMed abstract
  • Swanton, C and Govindan, R (2016)
    Clinical implications of genomic discoveries in lung cancer.
    New England Journal of Medicine 374, 1864-1873 PubMed abstract
  • Swanton, C; Soria, J-C; Bardelli, A; Biankin, A; Caldas, C; Chandarlapaty, S; de Koning, L; Dive, C; Feunteun, J; Leung, S-Y; Marais, R; Mardis, ER; McGranahan, N; Middleton, G; Quezada, SA; Rodón, J; Rosenfeld, N; Sotiriou, C and André, F (2016)
    Consensus on precision medicine for metastatic cancers: a report from the MAP conference.
    Annals of Oncology 27, 1443-1448 PubMed abstract
  • Szikriszt, B; Póti, Á; Pipek, O; Krzystanek, M; Kanu, N; Molnár, J; Ribli, D; Szeltner, Z; Tusnády, GE; Csabai, I; Szallasi, Z; Swanton, C and Szüts, D (2016)
    A comprehensive survey of the mutagenic impact of common cancer cytotoxics.
    Genome Biology 17, 99 PubMed abstract
  • Turajlic, S and Larkin, J (2016)
    Systemic treatment of advanced papillary renal cell carcinoma: Where next?
    European Journal of Cancer 69, 223-225 PubMed abstract
  • Turajlic, S and Swanton, C (2016)
    Metastasis as an evolutionary process.
    Science 352, 169-175 PubMed abstract
  • Venkatesan, S and Swanton, C (2016)
    Tumor evolutionary principles: how intratumor heterogeneity influences cancer treatment and outcome.
    ASCO Educational Book 35, e141-e149 PubMed abstract
  • Alizadeh, AA; Aranda, V; Bardelli, A; Blanpain, C; Bock, C; Borowski, C; Caldas, C; Califano, A; Doherty, M; Elsner, M; Esteller, M; Fitzgerald, R; Korbel, JO; Lichter, P; Mason, CE; Navin, N; Pe'er, D; Polyak, K; Roberts, CWM; Siu, L; Snyder, A; Stower, H; Swanton, C; Verhaak, RGW; Zenklusen, JC; Zuber, J and Zucman-Rossi, J (2015)
    Toward understanding and exploiting tumor heterogeneity.
    Nature Medicine 21, 846-853 PubMed abstract
  • Birkbak, NJ; Hiley, CT and Swanton, C (2015)
    Evolutionary precision medicine: a role for repeat epidermal growth factor receptor analysis in ALK-rearranged lung adenocarcinoma?
    Journal of Clinical Oncology 33, 3681-3683 PubMed abstract
  • Burris, HA; Hurwitz, H; Perez, EA; Spigel, D; Swanton, C; Hainsworth, JD; Leon, L; Beattie, M; Brammer, M and Sweeney, C (2015)
    MyPathway: An open-label phase IIa study of trastuzumab/pertuzumab, erlotinib, vemurafenib, and vismodegib in patients who have advanced solid tumors with mutations or gene expression abnormalities targeted by these agents.
    Journal of Clinical Oncology 33, TPS11111
  • de Bruin, EC; McGranahan, N and Swanton, C (2015)
    Analysis of intratumor heterogeneity unravels lung cancer evolution.
    Molecular & Cellular Oncology 2, e985549 PubMed abstract
  • Dewhurst, S and Swanton, C (2015)
    Tetraploidy and CIN: a dangerous combination.
    Cell Cycle 14, 3217 PubMed abstract
  • Di Leo, A; Curigliano, G; Diéras, V; Malorni, L; Sotiriou, C; Swanton, C; Thompson, A; Tutt, A and Piccart, M (2015)
    New approaches for improving outcomes in breast cancer in Europe.
    Breast 24, 321-330 PubMed abstract
  • Favero, F; McGranahan, N; Salm, M; Birkbak, NJ; Sanborn, JZ; Benz, SC; Becq, J; Peden, JF; Kingsbury, Z; Grocok, RJ; Humphray, S; Bentley, D; Spencer-Dene, B; Gutteridge, A; Brada, M; Roger, S; Dietrich, P-Y; Forshew, T; Gerlinger, M; Rowan, A; Stamp, G; Eklund, AC; Szallasi, Z and Swanton, C (2015)
    Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.
    Annals of Oncology 26, 880-887 PubMed abstract
  • Gasson, S; Bliss, J; Jamal-Hanjani, M; Krebs, M; Swanton, C and Wilcox, M (2015)
    The value of patient and public involvement in trial design and development.
    Clinical Oncology 27, 747-749 PubMed abstract
  • Gerlinger, M; Catto, JW; Orntoft, TF; Real, FX; Zwarthoff, EC and Swanton, C (2015)
    Intratumour heterogeneity in urologic cancers: from molecular evidence to clinical implications.
    European Urology 67, 729-737 PubMed abstract
  • Gulati, S; Turajlic, S; Larkin, J; Bates, PA and Swanton, C (2015)
    Relapse models for clear cell renal carcinoma.
    Lancet Oncology 16, e376-e378 PubMed abstract
  • Jamal-Hanjani, M; A'Hern, R; Birkbak, NJ; Gorman, P; Grönroos, E; Ngang, S; Nicola, P; Rahman, L; Thanopoulou, E; Kelly, G; Ellis, P; Barrett-Lee, P; Johnston, SRD; Bliss, J; Roylance, R and Swanton, C (2015)
    Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial.
    Annals of Oncology 26, 1340-1346 PubMed abstract
  • Jamal-Hanjani, M; De Bruin, E; Wilson, G; McGranahan, N; Rowan, A; Mosko, M; Metzler, H; Nygren, A and Swanton, C (2015)
    Intratumor heterogeneity and the detection of potential driver mutations in cfDNA in a NSCLC cohort using UltraSEEKTM.
    Cancer Research 75, Abstract 5249
  • Jamal-Hanjani, M; Quezada, SA; Larkin, J and Swanton, C (2015)
    Translational implications of tumor heterogeneity.
    Clinical Cancer Research 21, 1258-1266 PubMed abstract
  • Kanu, N; Grönroos, E; Martinez, P; Burrell, RA; Yi Goh, X; Bartkova, J; Maya-Mendoza, A; Mistrik, M; Rowan, AJ; Patel, H; Rabinowitz, A; East, P; Wilson, G; Santos, CR; McGranahan, N; Gulati, S; Gerlinger, M; Birkbak, NJ; Joshi, T; Alexandrov, LB; Stratton, MR; Powles, T; Matthews, N; Bates, PA; Stewart, A; Szallasi, Z; Larkin, J; Bartek, J and Swanton, C (2015)
    SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.
    Oncogene 34, 5699-5708 PubMed abstract
  • Kanu, N; Zhang, T; Burrell, RA; Chakraborty, A; Cronshaw, J; Da Costa, C; Grönroos, E; Pemberton, HN; Anderton, E; Gonzalez, L; Sabbioneda, S; Ulrich, HD; Swanton, C and Behrens, A (2015)
    RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.
    Oncogene 35, 4009-4019 PubMed abstract
  • Kovac, M; Navas, C; Horswell, S; Salm, M; Bardella, C; Rowan, A; Stares, M; Castro-Giner, F; Fisher, R; de Bruin, EC; Kovacova, M; Gorman, M; Makino, S; Williams, J; Jaeger, E; Jones, A; Howarth, K; Larkin, J; Pickering, L; Gore, M; Nicol, DL; Hazell, S; Stamp, G; O'Brien, T; Challacombe, B; Matthews, N; Phillimore, B; Begum, S; Rabinowitz, A; Varela, I; Chandra, A; Horsfield, C; Polson, A; Tran, M; Bhatt, R; Terracciano, L; Eppenberger-Castori, S; Protheroe, A; Maher, E; El Bahrawy, M; Fleming, S; Ratcliffe, P; Heinimann, K; Swanton, C and Tomlinson, I (2015)
    Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
    Nature Communications 6, 6336 PubMed abstract
  • Marquard, AM; Birkbak, NJ; Thomas, CE; Favero, F; Krzystanek, M; Lefebvre, C; Ferté, C; Jamal-Hanjani, M; Wilson, GA; Shafi, S; Swanton, C; André, F; Szallasi, Z and Eklund, AC (2015)
    TumorTracer: a method to identify the tissue of origin from the somatic mutations of a tumor specimen.
    BMC Medical Genomics 8, 58 PubMed abstract
  • McGranahan, N; Favero, F; de Bruin, EC; Birkbak, NJ; Szallasi, Z and Swanton, C (2015)
    Clonal status of actionable driver events and the timing of mutational processes in cancer evolution.
    Science Translational Medicine 7, 283ra254 PubMed abstract
  • McGranahan, N and Swanton, C (2015)
    Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.
    Cancer Cell 27, 15-26 PubMed abstract
  • Middleton, G; Crack, LR; Popat, S; Swanton, C; Hollingsworth, SJ; Buller, R; Walker, I; Carr, TH; Wherton, D and Billingham, LJ (2015)
    The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer.
    Annals of Oncology 26, 2464-2469 PubMed abstract
  • Murugaesu, N; Wilson, GA; Birkbak, NJ; Watkins, TBK; McGranahan, N; Kumar, S; Abbassi-Ghadi, N; Salm, M; Mitter, R; Horswell, S; Rowan, A; Phillimore, B; Biggs, J; Begum, S; Matthews, N; Hochhauser, D; Hanna, GB and Swanton, C (2015)
    Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.
    Cancer Discovery 5, 821-831 PubMed abstract
  • Soultati, A; Stares, M; Swanton, C; Larkin, J and Turajlic, S (2015)
    How should clinicians address intratumour heterogeneity in clear cell renal cell carcinoma?
    Current Opinion in Urology 25, 358-366 PubMed abstract
  • Swanton, C (2015)
    Cancer evolution constrained by mutation order.
    New England Journal of Medicine 372, 661-663 PubMed abstract
  • Swanton, C; McGranahan, N; Starrett, GJ and Harris, RS (2015)
    APOBEC enzymes: Mutagenic fuel for cancer evolution and heterogeneity.
    Cancer Discovery 5, 704-712 PubMed abstract
  • Turajlic, S; Larkin, J and Swanton, C (2015)
    Academically led clinical trials: challenges and opportunities.
    Annals of Oncology 26, 2010-2011 PubMed abstract
  • Turajlic, S; Larkin, J and Swanton, C (2015)
    SnapShot: Renal cell carcinoma.
    Cell 163, 1556-1556.e1551 PubMed abstract
  • Turajlic, S; McGranahan, N and Swanton, C (2015)
    Inferring mutational timing and reconstructing tumour evolutionary histories.
    Biochimica et Biophysica Acta 1855, 264-275 PubMed abstract
  • Turajlic, S and Swanton, C (2015)
    Gastrointestinal cancer: Tracking tumour evolution through liquid biopsy.
    Nature Reviews Clinical Oncology 12, 565-566 PubMed abstract
  • Walther, V; Hiley, CT; Shibata, D; Swanton, C; Turner, PE and Maley, CC (2015)
    Can oncology recapitulate paleontology? Lessons from species extinctions.
    Nature Reviews Clinical Oncology 12, 273-285 PubMed abstract
  • Zardavas, D; Irrthum, A; Swanton, C and Piccart, M (2015)
    Clinical management of breast cancer heterogeneity.
    Nature Reviews Clinical Oncology 12, 381-394 PubMed abstract
  • Andre, F; Mardis, E; Salm, M; Soria, JC; Siu, LL and Swanton, C (2014)
    Prioritizing targets for precision cancer medicine.
    Annals of Oncology 25, 2295-2303 PubMed abstract
  • Bakhoum, SF and Swanton, C (2014)
    Chromosomal instability, aneuploidy, and cancer.
    Frontiers in Oncology 4, 161 PubMed abstract
  • Bruin, ED; McGranahan, N; Yates, L; Jamal-Hanjani, M; Salm, M; Mitter, R; Shafi, S; Murugaesu, N; Rowan, A; Gerlinger, M; Wedge, D; Horswell, S; Varela, I; Tom, W; Parikh, C; Harkins, T; Lee, C; Matthews, N; Stewart, A; Campbell, P and Swanton, C (2014)
    Intratumor heterogeneity in non-small cell lung cancer inferred by multi-region exome sequencing.
    Cancer Research 74, Abstract 983
  • Burrell, RA; McClelland, SE; Bartek, J and Swanton, C (2014)
    Response to Bakhoum et al.
    Current Biology 24, R150 PubMed abstract
  • Burrell, RA and Swanton, C (2014)
    The evolution of the unstable cancer genome.
    Current Opinion in Genetics & Development 24, 61-67 PubMed abstract
  • Burrell, RA and Swanton, C (2014)
    Tumour heterogeneity and the evolution of polyclonal drug resistance.
    Molecular Oncology 8, 1095-1111 PubMed abstract
  • Crockford, A; Jamal-Hanjani, M; Hicks, J and Swanton, C (2014)
    Implications of intratumour heterogeneity for treatment stratification.
    Journal of Pathology 232, 264-273 PubMed abstract
  • De Bruin, E; McGranahan, N; Salm, M; Wedge, D; Mitter, R; Yates, L; Matthews, N; Stewart, A; Campbell, P and Swanton, C (2014)
    Intra-tumour heterogeneity in early-stage lung cancer inferred by multi-region sequencing.
    European Journal of Cancer 50, S4, Abstract 10
  • de Bruin, EC; McGranahan, N; Mitter, R; Salm, M; Wedge, DC; Yates, L; Jamal-Hanjani, M; Shafi, S; Murugaesu, N; Rowan, AJ; Grönroos, E; Muhammad, MA; Horswell, S; Gerlinger, M; Varela, I; Jones, D; Marshall, J; Voet, T; Van Loo, P; Rassl, DM; Rintoul, RC; Janes, SM; Lee, S-M; Forster, M; Ahmad, T; Lawrence, D; Falzon, M; Capitanio, A; Harkins, TT; Lee, CC; Tom, W; Teefe, E; Chen, S-C; Begum, S; Rabinowitz, A; Phillimore, B; Spencer-Dene, B; Stamp, G; Szallasi, Z; Matthews, N; Stewart, A; Campbell, P and Swanton, C (2014)
    Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.
    Science 346, 251-256 PubMed abstract
  • Dewhurst, SM; McGranahan, N; Burrell, RA; Rowan, AJ; Gronroos, E; Endesfelder, D; Joshi, T; Mouradov, D; Gibbs, P; Ward, RL; Hawkins, NJ; Szallasi, Z; Sieber, OM and Swanton, C (2014)
    Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.
    Cancer Discovery 4, 175-185 PubMed abstract
  • Endesfelder, D; Burrell, RA; Kanu, N; McGranahan, N; Howell, M; Parker, PJ; Downward, J; Swanton, C and Kschischo, M (2014)
    Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.
    Cancer Research 74, 4853-4863 PubMed abstract
  • Fisher, R; Horswell, S; Rowan, A; Salm, MP; de Bruin, EC; Gulati, S; McGranahan, N; Stares, M; Gerlinger, M; Varela, I; Crockford, A; Favero, F; Quidville, V; André, F; Navas, C; Grönroos, E; Nicol, D; Hazell, S; Hrouda, D; O'Brien, T; Matthews, N; Phillimore, B; Begum, S; Rabinowitz, A; Biggs, J; Bates, PA; McDonald, NQ; Stamp, G; Spencer-Dene, B; Hsieh, JJ; Xu, J; Pickering, L; Gore, M; Larkin, J and Swanton, C (2014)
    Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution.
    Genome Biology 15, 433 PubMed abstract
  • Gaykema, SBM; Schröder, CP; Vitfell-Rasmussen, J; Chua, S; Oude Munnink, TH; Brouwers, AH; Bongaerts, AHH; Akimov, M; Fernandez-Ibarra, C; Lub-de Hooge, MN; de Vries, EGE; Swanton, C and Banerji, U (2014)
    89Zr-trastuzumab and 89Zr-bevacizumab PET to evaluate the effect of the HSP90 inhibitor NVP-AUY922 in metastatic breast cancer patients.
    Clinical Cancer Research 20, 3945-3954 PubMed abstract
  • Gerlinger, M; Horswell, S; Larkin, J; Rowan, AJ; Salm, MP; Varela, I; Fisher, R; McGranahan, N; Matthews, N; Santos, CR; Martinez, P; Phillimore, B; Begum, S; Rabinowitz, A; Spencer-Dene, B; Gulati, S; Bates, PA; Stamp, G; Pickering, L; Gore, M; Nicol, DL; Hazell, S; Futreal, PA; Stewart, A and Swanton, C (2014)
    Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.
    Nature Genetics 46, 225-233 PubMed abstract
  • Gerlinger, M; McGranahan, N; Dewhurst, SM; Burrell, RA; Tomlinson, I and Swanton, C (2014)
    Cancer: evolution within a lifetime.
    Annual Review of Genetics 48, 215-236 PubMed abstract
  • Gulati, S; Martinez, P; Joshi, T; Birkbak, NJ; Santos, CR; Rowan, AJ; Pickering, L; Gore, M; Larkin, J; Szallasi, Z; Bates, PA; Swanton, C and Gerlinger, M (2014)
    Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers.
    European Urology 66, 936-948 PubMed abstract
  • Hiley, C; de Bruin, EC; McGranahan, N and Swanton, C (2014)
    Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine.
    Genome Biology 15, 453 PubMed abstract
  • Hiley, CT and Swanton, C (2014)
    Spatial and temporal cancer evolution: causes and consequences of tumour diversity.
    Clinical Medicine 14 , s33-s37 PubMed abstract
  • Infante, JR and Swanton, C (2014)
    Combined inhibition of BRAF and MEK in melanoma patients.
    Lancet Oncology 15, 908-910 PubMed abstract
  • Jamal-Hanjani, M; Hackshaw, A; Ngai, Y; Shaw, J; Dive, C; Quezada, S; Middleton, G; de Bruin, E; Le Quesne, J; Shafi, S; Falzon, M; Horswell, S; Blackhall, F; Khan, I; Janes, S; Nicolson, M; Lawrence, D; Forster, M; Fennell, D; Lee, S-M; Lester, J; Kerr, K; Muller, S; Iles, N; Smith, S; Murugaesu, N; Mitter, R; Salm, M; Stuart, A; Matthews, N; Adams, H; Ahmad, T; Attanoos, R; Bennett, J; Birkbak, NJ; Booton, R; Brady, G; Buchan, K; Capitano, A; Chetty, M; Cobbold, M; Crosbie, P; Davies, H; Denison, A; Djearman, M; Goldman, J; Haswell, T; Joseph, L; Kornaszewska, M; Krebs, M; Langman, G; MacKenzie, M; Millar, J; Morgan, B; Naidu, B; Nonaka, D; Peggs, K; Pritchard, C; Remmen, H; Rowan, A; Shah, R; Smith, E; Summers, Y; Taylor, M; Veeriah, S; Waller, D; Wilcox, B; Wilcox, M; Woolhouse, I; McGranahan, N and Swanton, C (2014)
    Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
    PLOS Biology 12, e1001906 PubMed abstract
  • Lönnstedt, IM; Caramia, F; Li, J; Fumagalli, D; Salgado, R; Rowan, A; Salm, M; Kanu, N; Savas, P; Horswell, S; Gade, S; Loibl, S; Neven, P; Sotiriou, C; Swanton, C; Loi, S and Speed, TP (2014)
    Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data.
    Genome Biology 15, 470 PubMed abstract
  • Molnár, J; Póti, Á; Pipek, O; Krzystanek, M; Kanu, N; Swanton, C; Tusnády, GE; Szallasi, Z; Csabai, I and Szüts, D (2014)
    The genome of the chicken DT40 bursal lymphoma cell line.
    G3 4, 2231-2240 PubMed abstract
  • Ng, CKY; Weigelt, B; A'Hern, R; Bidard, F-C; Lemetre, C; Swanton, C; Shen, R and Reis-Filho, JS (2014)
    Predictive performance of microarray gene signatures: impact of tumor heterogeneity and multiple mechanisms of drug resistance.
    Cancer Research 74, 2946-2961 PubMed abstract
  • Roylance, R; Endesfelder, D; Jamal-Hanjani, M; Burrell, RA; Gorman, P; Sander, J; Murphy, N; Birkbak, NJ; Hanby, AM; Speirs, V; Johnston, SRD; Kschischo, M and Swanton, C (2014)
    Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer.
    Breast Cancer Research and Treatment 148, 221-229 PubMed abstract
  • Staples, CJ; Myers, KN; Beveridge, RDD; Patil, AA; Howard, AE; Barone, G; Lee, AJX; Swanton, C; Howell, M; Maslen, S; Skehel, JM; Boulton, SJ and Collis, SJ (2014)
    Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.
    Journal of Cell Science 127, 2910-2919 PubMed abstract
  • Stewart, GD; Harrison, DJ; Swanton, C; Lewis, R; Bliss, J; Larkin, J and Nicol, DL (2014)
    Multidisciplinary urological engagement in translational renal cancer research.
    BJU International 114, 474-475 PubMed abstract
  • Swanton, C (2014)
    Cancer evolution: the final frontier of precision medicine?
    Annals of Oncology 25, 549-551 PubMed abstract
  • Swanton, C (2014)
    SAFIR01: steps towards precision treatment in breast cancer.
    Lancet Oncology 15, 242-243 PubMed abstract
  • Swanton, C; Andre, F and Mardis, E (2014)
    Deciphering root causes of intrinsic BRAF inhibitor resistance in melanoma: ushering in a new genomics case reports feature for Annals of Oncology.
    Annals of Oncology 25, 917-918 PubMed abstract
  • Swanton, C and Beck, S (2014)
    Epigenetic noise fuels cancer evolution.
    Cancer Cell 26, 775-776 PubMed abstract
  • Adelman, CA; Lolo, RL; Birkbak, NJ; Murina, O; Matsuzaki, K; Horejsi, Z; Parmar, K; Borel, V; Skehel, JM; Stamp, G; D'Andrea, A; Sartori, AA; Swanton, C and Boulton, SJ (2013)
    HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
    Nature 502, 381-384 PubMed abstract
  • A'Hern, RP; Jamal-Hanjani, M; Szász, AM; Johnston, SRD; Reis-Filho, JS; Roylance, R and Swanton, C (2013)
    Taxane benefit in breast cancer--a role for grade and chromosomal stability.
    Nature Reviews Clinical Oncology 10, 357-364 PubMed abstract
  • Azim, HA, Jr.; Michiels, S; Zagouri, F; Delaloge, S; Filipits, M; Namer, M; Neven, P; Symmans, WF; Thompson, A; André, F; Loi, S and Swanton, C (2013)
    Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement.
    Annals of Oncology 24, 647-654 PubMed abstract
  • Burrell, RA; McClelland, SE; Endesfelder, D; Groth, P; Weller, M-C; Shaikh, N; Domingo, E; Kanu, N; Dewhurst, SM; Gronroos, E; Chew, SK; Rowan, AJ; Schenk, A; Sheffer, M; Howell, M; Kschischo, M; Behrens, A; Helleday, T; Bartek, J; Tomlinson, IP and Swanton, C (2013)
    Replication stress links structural and numerical cancer chromosomal instability.
    Nature 494, 492-496 PubMed abstract
  • Burrell, RA; McGranahan, N; Bartek, J and Swanton, C (2013)
    The causes and consequences of genetic heterogeneity in cancer evolution.
    Nature 501, 338-345 PubMed abstract
  • Datta, RS; Gutteridge, A; Swanton, C; Maley, CC and Graham, TA (2013)
    Modelling the evolution of genetic instability during tumour progression.
    Evolutionary Applications 6, 20-33 PubMed abstract
  • de Bruin, EC; Taylor, TB and Swanton, C (2013)
    Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications.
    Genome Medicine 5, 101 PubMed abstract
  • Fisher, R; Pusztai, L and Swanton, C (2013)
    Cancer heterogeneity: implications for targeted therapeutics.
    British Journal of Cancer 108, 479-485 PubMed abstract
  • Gerlinger, M; Norton, L and Swanton, C (2013)
    Acquired resistance to crizotinib from a mutation in CD74-ROS1.
    New England Journal of Medicine 369, 1172-1173 PubMed abstract
  • Gerlinger, M; Quezada, SA; Peggs, KS; Furness, AJS; Fisher, R; Marafioti, T; Shende, VH; McGranahan, N; Rowan, AJ; Hazell, S; Hamm, D; Robins, HS; Pickering, L; Gore, M; Nicol, DL; Larkin, J and Swanton, C (2013)
    Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas.
    Journal of Pathology 231, 424-432 PubMed abstract
  • Horswell, S; Matthews, N and Swanton, C (2013)
    Cancer heterogeneity and "the struggle for existence": diagnostic and analytical challenges.
    Cancer Letters 340, 220-226 PubMed abstract
  • Hudis, C; Swanton, C; Janjigian, YY; Lee, R; Sutherland, S; Lehman, R; Chandarlapaty, S; Hamilton, N; Gajria, D; Knowles, J; Shah, J; Shannon, K; Tetteh, E; Sullivan, DM; Moreno, C; Yan, L and Han, HS (2013)
    A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors.
    Breast Cancer Research 15, R110 PubMed abstract
  • Jamal-Hanjani, M; Thanopoulou, E; Peggs, KS; Quezada, SA and Swanton, C (2013)
    Tumour heterogeneity and immune-modulation.
    Current Opinion in Pharmacology 13, 497-503 PubMed abstract
  • Khattak, MA; Bakr, F; Krzystanek, M; Szallasi, Z; Gerlinger, M; Santos, C; Swanton, C; Pickering, LM; Gore, ME and Larkin, JMG (2013)
    Prognostic and predictive markers in metastatic renal cell carcinoma.
    Journal of Clinical Oncology 31, 971-972 PubMed abstract
  • Lu, L; Teixeira, VH; Yuan, Z; Graham, TA; Endesfelder, D; Kolluri, K; Al-Juffali, N; Hamilton, N; Nicholson, AG; Falzon, M; Kschischo, M; Swanton, C; Wright, NA; Carroll, B; Watt, FM; George, JP; Jensen, KB; Giangreco, A and Janes, SM (2013)
    LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.
    Journal of Pathology 229, 608-620 PubMed abstract
  • Martinez, P; Birkbak, NJ; Gerlinger, M; McGranahan, N; Burrell, RA; Rowan, AJ; Joshi, T; Fisher, R; Larkin, J; Szallasi, Z and Swanton, C (2013)
    Parallel evolution of tumour subclones mimics diversity between tumours.
    Journal of Pathology 230, 356-364 PubMed abstract
  • Martinez, P; McGranahan, N; Birkbak, NJ; Gerlinger, M and Swanton, C (2013)
    Computational optimisation of targeted DNA sequencing for cancer detection.
    Scientific Reports 3, 3309 PubMed abstract
  • Moorcraft, SY; Chau, I; Peckitt, C; Cunningham, D; Rao, S; Yim, KL; Walther, A; Jackson, CGCA; Stamp, G; Webb, J; Smith, G; Gillbanks, A and Swanton, C (2013)
    Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial.
    Investigational New Drugs 31, 1339-1344 PubMed abstract
  • Munoz, J; Swanton, C and Kurzrock, R (2013)
    Molecular profiling and the reclassification of cancer: divide and conquer.
    In: ASCO Educational Book. 2013 edition.
    American Society of Clinical Oncology, 2013. 127-134.
  • Murugaesu, N; Chew, SK and Swanton, C (2013)
    Adapting clinical paradigms to the challenges of cancer clonal evolution.
    American Journal of Pathology 182, 1962-1971 PubMed abstract
  • Swanton, C (2013)
    Plasma-derived tumor DNA analysis at whole-genome resolution.
    Clinical Chemistry 59, 6-8 PubMed abstract
  • Szász, AM; Ács, B; Ágoston, E; Sztupinszki, Z; Tőkés, A-M; Szittya, L; Székely, B; Szendrői, M; Li, Q; Harsányi, L; Tímár, J; Szállási, Z; Swanton, C; Győrffy, B and Kulka, J (2013)
    Egyszerűsített, alacsony költségű génexpressziós teszt az emlődaganatos betegségek kimenetelének előrejelzésére rutin patológiai blokkok felhasználásával [Simplified, low-cost gene expression profiling for the prediction of outcome in breast cancer based on routine histologic specimens].
    Orvosi Hetilap 154, 627-632 PubMed abstract
  • Szász, AM; Li, Q; Eklund, AC; Sztupinszki, Z; Rowan, A; Tökes, A-M; Székely, B; Kiss, A; Szendrői, M; Győrffy, B; Szállási, Z; Swanton, C and Kulka, J (2013)
    The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer.
    PLOS ONE 8, e56707 PubMed abstract
  • Székely, B; Iwamoto, T; Szász, AM; Qi, Y; Matsuoka, J; Symmans, WF; Tőkes, A-M; Kulka, J; Swanton, C and Pusztai, L (2013)
    A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories.
    Breast Cancer Research and Treatment 138, 691-698 PubMed abstract
  • Chapman, MH; Tidswell, R; Dooley, JS; Sandanayake, NS; Cerec, V; Deheragoda, M; Lee, AJX; Swanton, C; Andreola, F and Pereira, SP (2012)
    Whole genome RNA expression profiling of endoscopic biliary brushings provides data suitable for biomarker discovery in cholangiocarcinoma.
    Journal of Hepatology 56, 877-885 PubMed abstract
  • Fennell, DA and Swanton, C (2012)
    Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer.
    EPMA Journal 3, 6 PubMed abstract
  • Fisher, R; Larkin, J and Swanton, C (2012)
    Inter and intratumour heterogeneity: a barrier to individualized medical therapy in renal cell carcinoma?
    Frontiers in Oncology 2, 49 PubMed abstract
  • Gerlinger, M; Rowan, AJ; Horswell, S; Larkin, J; Endesfelder, D; Gronroos, E; Martinez, P; Matthews, N; Stewart, A; Tarpey, P; Varela, I; Phillimore, B; Begum, S; McDonald, NQ; Butler, A; Jones, D; Raine, K; Latimer, C; Santos, CR; Nohadani, M; Eklund, AC; Spencer-Dene, B; Clark, G; Pickering, L; Stamp, G; Gore, M; Szallasi, Z; Downward, J; Futreal, PA and Swanton, C (2012)
    Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
    New England Journal of Medicine 366, 883-892 PubMed abstract
  • Gerlinger, M; Santos, CR; Spencer-Dene, B; Martinez, P; Endesfelder, D; Burrell, RA; Vetter, M; Jiang, M; Saunders, RE; Kelly, G; Dykema, K; Rioux-Leclercq, N; Stamp, G; Patard, JJ; Larkin, J; Howell, M and Swanton, C (2012)
    Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.
    Journal of Pathology 227, 146-156 PubMed abstract
  • Hewish, M; Stamp, G; Puckey, L; Shanley, S; Costello, C; Webb, J; Hulkki Wilson, S; Gonzalez de Castro, D; Barbachano, Y; Saffery, C; Swanton, C; Lord, CJ; Reis-Filho, JS; Ashworth, A; Chau, I and Cunningham, D (2012)
    Impact of mismatch repair (MMR) testing on colorectal cancer (CRC) oncology clinical practice.
    Journal of Clinical Oncology 30, 603 PubMed abstract
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    Intratumor heterogeneity: seeing the wood for the trees.
    Science Translational Medicine 4, 127ps110 PubMed abstract
  • Yap, TA; Swanton, C and de Bono, JS (2012)
    Personalization of prostate cancer prevention and therapy: are clinically qualified biomarkers in the horizon?
    EPMA Journal 3, 3 PubMed abstract
  • Barton, S and Swanton, C (2011)
    Recent developments in treatment stratification for metastatic breast cancer.
    Drugs 71, 2099-2113 PubMed abstract
  • Birkbak, NJ; Eklund, AC; Li, Q; McClelland, SE; Endesfelder, D; Tan, P; Tan, IB; Richardson, AL; Szallasi, Z and Swanton, C (2011)
    Paradoxical relationship between chromosomal instability and survival outcome in cancer.
    Cancer Research 71, 3447-3452 PubMed abstract
  • Endesfelder, D; McGranahan, N; Birkbak, NJ; Szallasi, Z; Kschischo, M; Graham, TA and Swanton, C (2011)
    A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.
    Oncotarget 2, 529-537 PubMed abstract
  • Fisher, R; Larkin, J and Swanton, C (2011)
    Delivering preventive, predictive and personalised cancer medicine for renal cell carcinoma: the challenge of tumour heterogeneity.
    EPMA Journal 3, 1 PubMed abstract
  • Golubnitschaja, O; Swanton, C; Danesi, R and Costigliola, V (2011)
    Promoting predictive, preventive and personalised medicine: European event of global importance.
    EPMA Journal 2, 131-136 PubMed abstract
  • Kumar, MS and Swanton, C (2011)
    KRAS 3ʹ-UTR variants and stratification of breast-cancer risk.
    Lancet Oncology 12, 318-319 PubMed abstract
  • Larkin, J; Swanton, C and Pickering, L (2011)
    Optimizing treatment of metastatic renal cell carcinoma by changing mechanism of action.
    Expert Review of Anticancer Therapy 11, 639-649 PubMed abstract
  • Lee, AJX; Endesfelder, D; Rowan, AJ; Walther, A; Birkbak, NJ; Futreal, PA; Downward, J; Szallasi, Z; Tomlinson, IPM; Howell, M; Kschischo, M and Swanton, C (2011)
    Chromosomal instability confers intrinsic multidrug resistance.
    Cancer Research 71, 1858-1870 PubMed abstract
  • Minchom, A; Starling, N and Swanton, C (2011)
    Cancer biology and treatment: a molecular and therapeutic overview.
    In: Anaesthesia, Intensive Care, and Pain Management for the Cancer Patient. Edited by Farquhar-Smith, P and Wigmore, T.
    Oxford, Oxford University Press, 2011. 13-25.
  • Roylance, R; Endesfelder, D; Gorman, P; Burrell, RA; Sander, J; Tomlinson, I; Hanby, AM; Speirs, V; Richardson, AL; Birkbak, NJ; Eklund, AC; Downward, J; Kschischo, M; Szallasi, Z and Swanton, C (2011)
    Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer.
    Cancer Epidemiology, Biomarkers & Prevention 20, 2183-2194 PubMed abstract
  • Swanton, C; Burrell, RA and Futreal, PA (2011)
    Breast cancer genome heterogeneity: a challenge to personalised medicine?
    Breast Cancer Research 13, 104 PubMed abstract
  • Wong, H; Leung, R; Kwong, A; Chiu, J; Liang, R; Swanton, C and Yau, T (2011)
    Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2+ metastatic breast cancer.
    Oncologist 16, 1535-1546 PubMed abstract
  • Barton, S; Starling, N and Swanton, C (2010)
    Predictive molecular markers of response to epidermal growth factor receptor (EGFR) family-targeted therapies.
    Current Cancer Drug Targets 10, 799-812 PubMed abstract
  • Basu, B; Ang, J; Blanco, M; Dowsett, M; Spicer, J; Tutt, A; Johnston, S; Wan, S; De Bono, J and Swanton, C (2010)
    Preliminary report of efficacy of abiraterone acetate in patients with estrogen (ER) or androgen receptor (AR) positive, advanced breast carcinoma resistant to standard endocrine therapies.
    EJC Supplements 8, 204-205
  • Brunetto, AT; Sarker, D; Papadatos-Pastos, D; Fehrmann, R; Kaye, SB; Johnston, S; Allen, M; De Bono, JS and Swanton, C (2010)
    A retrospective analysis of clinical outcome of patients with chemo-refractory metastatic breast cancer treated in a single institution phase I unit.
    British Journal of Cancer 103, 607-612 PubMed abstract
  • Burrell, RA; Juul, N; Johnston, SR; Reis-Filho, JS; Szallasi, Z and Swanton, C (2010)
    Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer.
    Journal of Cellular Biochemistry 111, 782-790 PubMed abstract
  • Gerlinger, M and Swanton, C (2010)
    How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine.
    British Journal of Cancer 103, 1139-1143 PubMed abstract
  • Johnston, SR; Swanton, C; Stein, SH; Liu, Y; Gagnon, RC; Trudeau, ME; Kautman, B; Martin, A and Salazar, VM (2010)
    Biomarker profiles and changes from baseline in trastuzumab (T) refractory HER2-positive inflammatory breast cancer (IBC) that predict decreases in tumor burden from lapatinib (L) monotherapy.
    Journal of Clinical Oncology 28, 10572
  • Juul, N; Szallasi, Z; Eklund, AC; Li, Q; Burrell, RA; Gerlinger, M; Valero, V; Andreopoulou, E; Esteva, FJ; Symmans, WF; Desmedt, C; Haibe-Kains, B; Sotiriou, C; Pusztai, L and Swanton, C (2010)
    Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials.
    Lancet Oncology 11, 358-365 PubMed abstract
  • Li, Q; Eklund, AC; Juul, N; Haibe-Kains, B; Workman, CT; Richardson, AL; Szallasi, Z and Swanton, C (2010)
    Minimising immunohistochemical false negative ER classification using a complementary 23 gene expression signature of ER status.
    PLOS ONE 5, e15031 PubMed abstract
  • McKeen, HD; Byrne, C; Jithesh, PV; Donley, C; Valentine, A; Yakkundi, A; O'Rourke, M; Swanton, C; McCarthy, HO; Hirst, DG and Robson, T (2010)
    FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.
    Cancer Research 70, 1090-1100 PubMed abstract
  • Swanton, C (2010)
    Breast cancer in the post-genomic era.
    British Journal of Cancer 103, 155
  • Swanton, C and Caldas, C (2010)
    From genomic landscapes to personalized cancer management—is there a roadmap?
    Annals of the New York Academy of Sciences 1210, 34-44 PubMed abstract
  • Swanton, C; Juul, N; Larkin, JM; Eklund, A; Li, Q; Desmedt, C; Sotiriou, C; Pusztai, L and Szallasi, Z (2010)
    Use of an RNA interference screen-derived mitotic and ceramide pathway metagene to predict response to paclitaxel combination chemotherapy in primary breast cancer.
    Journal of Clinical Oncology 28, 569
  • Swanton, C; Larkin, JM; Gerlinger, M; Eklund, AC; Howell, M; Stamp, G; Downward, J; Gore, M; Futreal, PA; Escudier, B; Andre, F; Albiges, L; Beuselinck, B; Oudard, S; Hoffmann, J; Gyorffy, B; Torrance, CJ; Boehme, KA; Volkmer, H; Toschi, L; Nicke, B; Beck, M and Szallasi, Z (2010)
    Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets.
    Genome Medicine 2, 53 PubMed abstract
  • Tan, DSW; Gerlinger, M; Teh, B-T and Swanton, C (2010)
    Anti-cancer drug resistance: understanding the mechanisms through the use of integrative genomics and functional RNA interference.
    European Journal of Cancer 46, 2166-2177 PubMed abstract
  • Tejpar, S; Bertagnolli, M; Bosman, F; Lenz, H-J; Garraway, L; Waldman, F; Warren, R; Bild, A; Collins-Brennan, D; Hahn, H; Harkin, DP; Kennedy, R; Ilyas, M; Morreau, H; Proutski, V; Swanton, C; Tomlinson, I; Delorenzi, M; Fiocca, R; Van Cutsem, E and Roth, A (2010)
    Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.
    Oncologist 15, 390-404 PubMed abstract

[Page last updated 1 Sep 2017]

Charles Swanton

charles.swanton@crick.ac.uk
+44 (0)20 379 62047

  • Qualifications and history
  • 1995 PhD, Imperial Cancer Research Fund, UK (this became Cancer Research UK in 2002)
  • 2002 Membership Royal College of Physicians
  • 2004 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK