Erik Sahai: Publications

  • Arwert, EN; Harney, AS; Entenberg, D; Wang, Y; Sahai, E; Pollard, JW and Condeelis, JS (2018)
    A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation.
    Cell Reports 23, 1239-1248 PubMed abstract
  • Böttcher, JP; Bonavita, E; Chakravarty, P; Blees, H; Cabeza-Cabrerizo, M; Sammicheli, S; Rogers, NC; Sahai, E; Zelenay, S and Reis e Sousa, C (2018)
    NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control.
    Cell 172, 1022-1037 e1014 PubMed abstract
  • Rhys, AD; Monteiro, P; Smith, C; Vaghela, M; Arnandis, T; Kato, T; Leitinger, B; Sahai, E; McAinsh, A; Charras, G and Godinho, SA (2018)
    Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.
    Journal of Cell Biology 217, 195-209 PubMed abstract
  • Gosens, R; Giangreco, A; Sahai, E and Chambers, RC (2017)
    Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.
    European Respiratory Review 26, 170060 PubMed abstract
  • Hirata, E and Sahai, E (2017)
    Tumor microenvironment and differential responses to therapy.
    Cold Spring Harbor Perspectives in Medicine 7, a026781 PubMed abstract
  • Labernadie, A; Kato, T; Brugués, A; Serra-Picamal, X; Derzsi, S; Arwert, E; Weston, A; González-Tarragó, V; Elosegui-Artola, A; Albertazzi, L; Alcaraz, J; Roca-Cusachs, P; Sahai, E and Trepat, X (2017)
    A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion.
    Nature Cell Biology 19, 224-237 PubMed abstract
  • Picco, N; Sahai, E; Maini, PK and Anderson, ARA (2017)
    Integrating models to quantify environment-mediated drug resistance.
    Cancer Research 77, 5409-5418 PubMed abstract
  • Sahai, E; Swanton, C and CRUK Marshall Symposium (2017)
    Evolution and cancer medicine - transformative insights.
    Nature Reviews Clinical Oncology 14, 709-710 PubMed abstract
  • Takaki, T; Montagner, M; Serres, MP; Le Berre, M; Russell, M; Collinson, L; Szuhai, K; Howell, M; Boulton, SJ; Sahai, E and Petronczki, M (2017)
    Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.
    Nature Communications 8, 16013 PubMed abstract
  • Avgustinova, A; Iravani, M; Robertson, D; Fearns, A; Gao, Q; Klingbeil, P; Hanby, AM; Speirs, V; Sahai, E; Calvo, F and Isacke, CM (2016)
    Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness.
    Nature Communications 7, 10305 PubMed abstract
  • Elbediwy, A; Vincent-Mistiaen, ZI; Spencer-Dene, B; Stone, RK; Boeing, S; Wculek, SK; Cordero, J; Tan, EH; Ridgway, R; Brunton, VG; Sahai, E; Gerhardt, H; Behrens, A; Malanchi, I; Sansom, OJ and Thompson, BJ (2016)
    Integrin signalling regulates YAP and TAZ to control skin homeostasis.
    Development 143, 1674-1687 PubMed abstract
  • Herraiz, C; Calvo, F; Pandya, P; Cantelli, G; Rodriguez-Hernandez, I; Orgaz, JL; Kang, N; Chu, T; Sahai, E and Sanz-Moreno, V (2016)
    Reactivation of p53 by a cytoskeletal sensor to control the balance between DNA damage and tumor dissemination.
    Journal of the National Cancer Institute 108, djv289 PubMed abstract
  • Seifert, H; Hirata, E; Gore, M; Khabra, K; Messiou, C; Larkin, J and Sahai, E (2016)
    Extrinsic factors can mediate resistance to BRAF inhibition in CNS melanoma metastases.
    Pigment Cell & Melanoma Research 29, 92-100 PubMed abstract
  • van de Ven, RAH; de Groot, JS; Park, D; van Domselaar, R; de Jong, D; Szuhai, K; van der Wall, E; Rueda, OM; Ali, HR; Caldas, C; van Diest, PJ; Hetzer, MW; Sahai, E and Derksen, PWB (2016)
    p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.
    Nature Communications 7, 13874 PubMed abstract
  • Calvo, F; Ranftl, R; Hooper, S; Farrugia, AJ; Moeendarbary, E; Bruckbauer, A; Batista, F; Charras, G and Sahai, E (2015)
    Cdc42EP3/BORG2 and septin network enables mechano-transduction and the emergence of cancer-associated fibroblasts.
    Cell Reports 13, 2699-2714 PubMed abstract
  • del Pozo Martin, Y; Park, D; Ramachandran, A; Ombrato, L; Calvo, F; Chakravarty, P; Spencer-Dene, B; Derzsi, S; Hill, CS; Sahai, E and Malanchi, I (2015)
    Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization.
    Cell Reports 13, 2456-2469 PubMed abstract
  • Hirata, E; Girotti, MR; Viros, A; Hooper, S; Spencer-Dene, B; Matsuda, M; Larkin, J; Marais, R and Sahai, E (2015)
    Intravital imaging reveals how BRaf inhibition generates drug tolerant microenvironments.
    Journal of Nuclear Medicine 56, 26, Abstract no. 21
  • Hirata, E; Girotti, MR; Viros, A; Hooper, S; Spencer-Dene, B; Matsuda, M; Larkin, J; Marais, R and Sahai, E (2015)
    Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.
    Cancer Cell 27, 574-588 PubMed abstract
  • Jenkins, RP; Hanisch, A; Soza-Ried, C; Sahai, E and Lewis, J (2015)
    Stochastic regulation of her1/7 gene expression is the source of noise in the zebrafish somite clock counteracted by Notch signalling.
    PLOS Computational Biology 11, e1004459 PubMed abstract
  • Lloyd, A and Sahai, E (2015)
    Chris Marshall 1949-2015.
    Nature Cell Biology 17, 1229 PubMed abstract
  • Madsen, CD; Hooper, S; Tozluoglu, M; Bruckbauer, A; Fletcher, G; Erler, JT; Bates, PA; Thompson, B and Sahai, E (2015)
    STRIPAK components determine mode of cancer cell migration and metastasis.
    Nature Cell Biology 17, 68-80 PubMed abstract
  • Madsen, CD; Pedersen, JT; Venning, FA; Singh, LB; Moeendarbary, E; Charras, G; Cox, TR; Sahai, E and Erler, JT (2015)
    Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.
    EMBO Reports 16, 1394-1408 PubMed abstract
  • Masuzzo, P; Martens, L; Ampe, C; Anderson, KI; Barry, J; De Wever, O; Debeir, O; Decaestecker, C; Dolznig, H; Friedl, P; Gaggioli, C; Geiger, B; Goldberg, IG; Horn, E; Horwitz, R; Kam, Z; Le Dévédec, SE; Vignjevic, DM; Moore, J; Olivo-Marin, J-C; Sahai, E; Sansone, SA; Sanz-Moreno, V; Strömblad, S; Swedlow, J; Textor, J; Van Troys, M and Zantl, R (2015)
    An open data ecosystem for cell migration research.
    Trends in Cell Biology 25, 55-58 PubMed abstract
  • Sadok, A; McCarthy, A; Caldwell, J; Collins, I; Garrett, MD; Yeo, M; Hooper, S; Sahai, E; Kuemper, S; Mardakheh, FK and Marshall, CJ (2015)
    Rho kinase inhibitors block melanoma cell migration and inhibit metastasis.
    Cancer Research 75, 2272-2284 PubMed abstract
  • Sahai, E (2015)
    Chris Marshall (1949-2015) - a personal reflection and tribute.
    Journal of Cell Science 128, 4033-4034 PubMed abstract
  • Thompson, BJ and Sahai, E (2015)
    MST kinases in development and disease.
    Journal of Cell Biology 210, 871-882 PubMed abstract
  • Tozluoglu, M; Mao, Y; Bates, PA and Sahai, E (2015)
    Cost-benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments.
    Journal of the Royal Society Interface 12, 20141355 PubMed abstract
  • Zelenay, S; van der Veen, AG; Böttcher, JP; Snelgrove, KJ; Rogers, N; Acton, SE; Chakravarty, P; Girotti, MR; Marais, R; Quezada, SA; Sahai, E and Reis e Sousa, C (2015)
    Cyclooxygenase-dependent tumor growth through evasion of immunity.
    Cell 162, 1257-1270 PubMed abstract
  • Acton, SE; Farrugia, AJ; Astarita, JL; Mourão-Sá, D; Jenkins, RP; Nye, E; Hooper, S; van Blijswijk, J; Rogers, NC; Snelgrove, KJ; Rosewell, I; Moita, LF; Stamp, G; Turley, SJ; Sahai, E and Reis e Sousa, C (2014)
    Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
    Nature 514, 498-502 PubMed abstract
  • Charras, G and Sahai, E (2014)
    Physical influences of the extracellular environment on cell migration.
    Nature Reviews Molecular Cell Biology 15, 813-824 PubMed abstract
  • Linch, M; Sanz-Garcia, M; Rosse, C; Riou, P; Peel, N; Madsen, CD; Sahai, E; Downward, J; Khwaja, A; Dillon, C; Roffey, J; Cameron, AJM and Parker, PJ (2014)
    Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.
    Carcinogenesis 35, 396-406 PubMed abstract
  • Manning, CS; Hooper, S and Sahai, EA (2014)
    Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells.
    Oncogene 34, 4320-4332 PubMed abstract
  • Briones-Orta, MA; Levy, L; Madsen, CD; Das, D; Erker, Y; Sahai, E and Hill, CS (2013)
    Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Cancer Research 73, 1800-1810 PubMed abstract
  • Calvo, F; Ege, N; Grande-Garcia, A; Hooper, S; Jenkins, RP; Chaudhry, SI; Harrington, K; Williamson, P; Moeendarbary, E; Charras, G and Sahai, E (2013)
    Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
    Nature Cell Biology 15, 637-646 PubMed abstract
  • Chaudhry, SI; Hooper, S; Nye, E; Williamson, P; Harrington, K and Sahai, E (2013)
    Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts.
    Oncogene 32, 747-758 PubMed abstract
  • Eccles, SA; Aboagye, EO; Ali, S; Anderson, AS; Armes, J; Berditchevski, F; Blaydes, JP; Brennan, K; Brown, NJ; Bryant, HE; Bundred, NJ; Burchell, JM; Campbell, AM; Carroll, JS; Clarke, RB; Coles, CE; Cook, GJR; Cox, A; Curtin, NJ; Dekker, LV; Silva, IdS; Duffy, SW; Easton, DF; Eccles, DM; Edwards, DR; Edwards, J; Evans, D; Fenlon, DF; Flanagan, JM; Foster, C; Gallagher, WM; Garcia-Closas, M; Gee, JMW; Gescher, AJ; Goh, V; Groves, AM; Harvey, AJ; Harvie, M; Hennessy, BT; Hiscox, S; Holen, I; Howell, SJ; Howell, A; Hubbard, G; Hulbert-Williams, N; Hunter, MS; Jasani, B; Jones, LJ; Key, TJ; Kirwan, CC; Kong, A; Kunkler, IH; Langdon, SP; Leach, MO; Mann, DJ; Marshall, JF; Martin, L; Martin, SG; Macdougall, JE; Miles, DW; Miller, WR; Morris, JR; Moss, SM; Mullan, P; Natrajan, R; O'Connor, JPB; O'Connor, R; Palmieri, C; Pharoah, PDP; Rakha, EA; Reed, E; Robinson, SP; Sahai, E; Saxton, JM; Schmid, P; Smalley, MJ; Speirs, V; Stein, R; Stingl, J; Streuli, CH; Tutt, ANJ; Velikova, G; Walker, RA; Watson, CJ; Williams, KJ; Young, LS and Thompson, AM (2013)
    Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
    Breast Cancer Research 15, R92 PubMed abstract
  • Entenberg, D; Kedrin, D; Wyckoff, J; Sahai, E; Condeelis, J and Segall, JE (2013)
    Imaging tumor cell movement in vivo.
    In: Current Protocols in Cell Biology. 2013 edition.
    Wiley, 2013. Unit 19.17.
  • Kadaba, R; Birke, H; Wang, J; Hooper, S; Andl, CD; Di Maggio, F; Soylu, E; Ghallab, M; Bor, D; Froeling, FE; Bhattacharya, S; Rustgi, AK; Sahai, E; Chelala, C; Sasieni, P and Kocher, HM (2013)
    Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes.
    Journal of Pathology 230, 107-117 PubMed abstract
  • Tozluoğlu, M; Tournier, AL; Jenkins, RP; Hooper, S; Bates, PA and Sahai, E (2013)
    Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions.
    Nature Cell Biology 15, 751-762 PubMed abstract
  • Friedl, P; Locker, J; Sahai, E and Segall, JE (2012)
    Classifying collective cancer cell invasion.
    Nature Cell Biology 14, 777-783 PubMed abstract
  • Hirata, E; Yukinaga, H; Kamioka, Y; Arakawa, Y; Miyamoto, S; Okada, T; Sahai, E and Matsuda, M (2012)
    In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion.
    Journal of Cell Science 125, 858-868 PubMed abstract
  • Arozarena, I; Sanchez-Laorden, B; Packer, L; Hidalgo-Carcedo, C; Hayward, R; Viros, A; Sahai, E and Marais, R (2011)
    Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.
    Cancer Cell 19, 45-57 PubMed abstract
  • Calvo, F and Sahai, E (2011)
    Cell communication networks in cancer invasion.
    Current Opinion in Cell Biology 23, 621-629 PubMed abstract
  • Calvo, F; Sanz-Moreno, V; Agudo-Ibáñez, L; Wallberg, F; Sahai, E; Marshall, CJ and Crespo, P (2011)
    RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
    Nature Cell Biology 13, 819-826 PubMed abstract
  • Hidalgo-Carcedo, C; Hooper, S; Chaudhry, SI; Williamson, P; Harrington, K; Leitinger, B and Sahai, E (2011)
    Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.
    Nature Cell Biology 13, 49-58 PubMed abstract
  • Sanz-Moreno, V; Gaggioli, C; Yeo, M; Albrengues, J; Wallberg, F; Viros, A; Hooper, S; Mitter, R; Féral, CC; Cook, M; Larkin, J; Marais, R; Meneguzzi, G; Sahai, E and Marshall, CJ (2011)
    ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.
    Cancer Cell 20, 229-245 PubMed abstract
  • Bilsland, LG; Sahai, E; Kelly, G; Golding, M; Greensmith, L and Schiavo, G (2010)
    Deficits in axonal transport precede ALS symptoms in vivo.
    Proceedings of the National Academy of Sciences of the United States of America 107, 20523-20528 PubMed abstract
  • Hooper, S; Gaggioli, C and Sahai, E (2010)
    A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.
    British Journal of Cancer 102, 392-402 PubMed abstract
  • Madsen, CD and Sahai, E (2010)
    Cancer dissemination--lessons from leukocytes.
    Developmental Cell 19, 13-26 PubMed abstract
  • Scott, RW; Hooper, S; Crighton, D; Li, A; König, I; Munro, J; Trivier, E; Wickman, G; Morin, P; Croft, DR; Dawson, J; Machesky, L; Anderson, KI; Sahai, EA and Olson, MF (2010)
    LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
    Journal of Cell Biology 191, 169-185 PubMed abstract

[Page last updated 1 Jun 2018]

Erik Sahai
+44 (0)20 379 61322

  • Qualifications and history
  • 1998 PhD in Biochemistry, University College, London, UK
  • 1998 Postdoctoral Fellow, Institute of Cancer Research, UK
  • 2003 Postdoctoral Fellow, Albert Einstein College of Medicine, USA
  • 2004 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK