Karen Vousden: Publications

  • Maddocks, ODK; Athineos, D; Cheung, EC; Lee, P; Zhang, T; van den Broek, NJF; Mackay, GM; Labuschagne, CF; Gay, D; Kruiswijk, F; Blagih, J; Vincent, DF; Campbell, KJ; Ceteci, F; Sansom, OJ; Blyth, K and Vousden, KH (2017)
    Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
    Nature 544, 372-376 PubMed abstract
  • Cheung, EC; Lee, P; Ceteci, F; Nixon, C; Blyth, K; Sansom, OJ and Vousden, KH (2016)
    Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine.
    Genes & Development 30, 52-63 PubMed abstract
  • Humpton, TJ and Vousden, KH (2016)
    Regulation of cellular metabolism and hypoxia by p53.
    Cold Spring Harbor Perspectives in Medicine 6, a026146 PubMed abstract
  • Kehrloesser, S; Osterburg, C; Tuppi, M; Schäfer, B; Vousden, KH and Dötsch, V (2016)
    Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.
    Cell Death and Differentiation 23, 1952-1960 PubMed abstract
  • Maddocks, ODK; Labuschagne, CF; Adams, PD and Vousden, KH (2016)
    Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells.
    Molecular Cell 61, 210-221 PubMed abstract
  • Meiser, J; Tumanov, S; Maddocks, O; Labuschagne, CF; Athineos, D; Van Den Broek, N; Mackay, GM; Gottlieb, E; Blyth, K; Vousden, K; Kamphorst, JJ and Vazquez, A (2016)
    Serine one-carbon catabolism with formate overflow.
    Science Advances 2, e1601273 PubMed abstract
  • Tajan, M and Vousden, KH (2016)
    The quid pro quo of the tumor/stromal interaction.
    Cell Metabolism 24, 645-646 PubMed abstract
  • Vousden, KH and Yang, M (2016)
    Location, location, location.
    Science 353, 1095-1096 PubMed abstract
  • Walton, J; Blagih, J; Ennis, D; Leung, E; Dowson, S; Farquharson, M; Tookman, LA; Orange, C; Athineos, D; Mason, S; Stevenson, D; Blyth, K; Strathdee, D; Balkwill, FR; Vousden, K; Lockley, M and McNeish, IA (2016)
    CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high-grade serous carcinoma.
    Cancer Research 76, 6118-6129 PubMed abstract
  • Yang, M and Vousden, KH (2016)
    Serine and one-carbon metabolism in cancer.
    Nature Reviews Cancer 16, 650-662 PubMed abstract
  • Buescher, JM; Antoniewicz, MR; Boros, LG; Burgess, SC; Brunengraber, H; Clish, CB; DeBerardinis, RJ; Feron, O; Frezza, C; Ghesquiere, B; Gottlieb, E; Hiller, K; Jones, RG; Kamphorst, JJ; Kibbey, RG; Kimmelman, AC; Locasale, JW; Lunt, SY; Maddocks, OD; Malloy, C; Metallo, CM; Meuillet, EJ; Munger, J; Nöh, K; Rabinowitz, JD; Ralser, M; Sauer, U; Stephanopoulos, G; St-Pierre, J; Tennant, DA; Wittmann, C; Vander Heiden, MG; Vazquez, A; Vousden, K; Young, JD; Zamboni, N and Fendt, S-M (2015)
    A roadmap for interpreting 13C metabolite labeling patterns from cells.
    Current Opinion in Biotechnology 34, 189-201 PubMed abstract
  • Deschoemaeker, S; Di Conza, G; Lilla, S; Martin-Pérez, R; Mennerich, D; Boon, L; Hendrikx, S; Maddocks, ODK; Marx, C; Radhakrishnan, P; Prenen, H; Schneider, M; Myllyharju, J; Kietzmann, T; Vousden, KH; Zanivan, S and Mazzone, M (2015)
    PHD1 regulates p53-mediated colorectal cancer chemoresistance.
    EMBO Molecular Medicine 7, 1350-1365 PubMed abstract
  • Gurpinar, E and Vousden, KH (2015)
    Hitting cancers' weak spots: vulnerabilities imposed by p53 mutation.
    Trends in Cell Biology 25, 486-495 PubMed abstract
  • Kruiswijk, F; Labuschagne, CF and Vousden, KH (2015)
    p53 in survival, death and metabolic health: a lifeguard with a licence to kill.
    Nature Reviews Molecular Cell Biology 16, 393-405 PubMed abstract
  • Lee, P; Hock, AK; Vousden, KH and Cheung, EC (2015)
    p53- and p73-independent activation of TIGAR expression in vivo.
    Cell Death & Disease 6, e1842 PubMed abstract
  • Stindt, MH; Muller, PAJ; Ludwig, RL; Kehrloesser, S; Dötsch, V and Vousden, KH (2015)
    Functional interplay between MDM2, p63/p73 and mutant p53.
    Oncogene 34, 4300-4310 PubMed abstract
  • Vousden, KH (2015)
    Chris Marshall (1949-2015) Obituary.
    Cancer Cell 28, 271-272
  • D'Alessandro, A; Amelio, I; Berkers, CR; Antonov, A; Vousden, KH; Melino, G and Zolla, L (2014)
    Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense.
    Oncotarget 5, 7722-7733 PubMed abstract
  • Haller, M; Hock, AK; Giampazolias, E; Oberst, A; Green, DR; Debnath, J; Ryan, KM; Vousden, KH and Tait, SWG (2014)
    Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity.
    Autophagy 10, 2269-2278 PubMed abstract
  • Hock, AK; Lee, P; Maddocks, ODK; Mason, SM; Blyth, K and Vousden, KH (2014)
    iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems.
    Cell Cycle 13, 220-226 PubMed abstract
  • Hock, AK; Vigneron, AM and Vousden, KH (2014)
    Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity.
    Journal of Biological Chemistry 289, 34862-34870 PubMed abstract
  • Hock, AK and Vousden, KH (2014)
    The role of ubiquitin modification in the regulation of p53.
    Biochimica et Biophysica Acta 1843, 137-149 PubMed abstract
  • Labuschagne, CF; van den Broek, NJF; Mackay, GM; Vousden, KH and Maddocks, ODK (2014)
    Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.
    Cell Reports 7, 1248-1258 PubMed abstract
  • Lee, P; Vousden, KH and Cheung, EC (2014)
    TIGAR, TIGAR, burning bright.
    Cancer & Metabolism 2, 1 PubMed abstract
  • Maddocks, ODK; Labuschagne, CF and Vousden, KH (2014)
    Localization of NADPH production: a wheel within a wheel.
    Molecular Cell 55, 158-160 PubMed abstract
  • Muller, PAJ; Trinidad, AG; Caswell, PT; Norman, JC and Vousden, KH (2014)
    Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.
    Journal of Biological Chemistry 289, 122-132 PubMed abstract
  • Muller, PAJ and Vousden, KH (2014)
    Mutant p53 in cancer: new functions and therapeutic opportunities.
    Cancer Cell 25, 304-317 PubMed abstract
  • Paulus-Hock, V; Cheung, EC; Roxburgh, P; Vousden, KH and Hock, AK (2014)
    iRFP is a real time marker for transformation based assays in high content screening.
    PLOS ONE 9, e98399 PubMed abstract
  • Phesse, TJ; Myant, KB; Cole, AM; Ridgway, RA; Pearson, H; Muncan, V; van den Brink, GR; Vousden, KH; Sears, R; Vassilev, LT; Clarke, AR and Sansom, OJ (2014)
    Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.
    Cell Death and Differentiation 21, 956-966 PubMed abstract
  • Tan, EH; Morton, JP; Timpson, P; Tucci, P; Melino, G; Flores, ER; Sansom, OJ; Vousden, KH and Muller, PAJ (2014)
    Functions of TAp63 and p53 in restraining the development of metastatic cancer.
    Oncogene 33, 3325-3333 PubMed abstract
  • Berkers, CR; Maddocks, ODK; Cheung, EC; Mor, I and Vousden, KH (2013)
    Metabolic regulation by p53 family members.
    Cell Metabolism 18, 617-633 PubMed abstract
  • Cheung, EC; Athineos, D; Lee, P; Ridgway, RA; Lambie, W; Nixon, C; Strathdee, D; Blyth, K; Sansom, OJ and Vousden, KH (2013)
    TIGAR is required for efficient intestinal regeneration and tumorigenesis.
    Developmental Cell 25, 463-477 PubMed abstract
  • Dickens, MP; Roxburgh, P; Hock, A; Mezna, M; Kellam, B; Vousden, KH and Fischer, PM (2013)
    5-deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.
    Bioorganic & Medicinal Chemistry 21, 6868-6877 PubMed abstract
  • Kaelin, W; Livingston, D; Loda, M; Vousden, K and Mihich, E (2013)
    Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis.
    Cancer Research 73, 6124-6127 PubMed abstract
  • Maddocks, ODK; Berkers, CR; Mason, SM; Zheng, L; Blyth, K; Gottlieb, E and Vousden, KH (2013)
    Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.
    Nature 493, 542-546 PubMed abstract
  • Muller, PAJ; Trinidad, AG; Timpson, P; Morton, JP; Zanivan, S; van den Berghe, PVE; Nixon, C; Karim, SA; Caswell, PT; Noll, JE; Coffill, CR; Lane, DP; Sansom, OJ; Neilsen, PM; Norman, JC and Vousden, KH (2013)
    Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.
    Oncogene 32, 1252-1265 PubMed abstract
  • Muller, PAJ and Vousden, KH (2013)
    p53 mutations in cancer.
    Nature Cell Biology 15, 2-8 PubMed abstract
  • Trinidad, AG; Muller, PAJ; Cuellar, J; Klejnot, M; Nobis, M; Valpuesta, JM and Vousden, KH (2013)
    Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity.
    Molecular Cell 50, 805-817 PubMed abstract
  • Chaneton, B; Hillmann, P; Zheng, L; Martin, ACL; Maddocks, ODK; Chokkathukalam, A; Coyle, JE; Jankevics, A; Holding, FP; Vousden, KH; Frezza, C; O'Reilly, M and Gottlieb, E (2012)
    Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
    Nature 491, 458-462 PubMed abstract
  • Cheung, EC; Ludwig, RL and Vousden, KH (2012)
    Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death.
    Proceedings of the National Academy of Sciences of the United States of America 109, 20491-20496 PubMed abstract
  • Coffill, CR; Muller, PAJ; Oh, HK; Neo, SP; Hogue, KA; Cheok, CF; Vousden, KH; Lane, DP; Blackstock, WP and Gunaratne, J (2012)
    Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
    EMBO Reports 13, 638-644 PubMed abstract
  • Dolezelova, P; Cetkovska, K; Vousden, KH and Uldrijan, S (2012)
    Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers.
    Cell Cycle 11, 953-962 PubMed abstract
  • Dolezelova, P; Cetkovska, K; Vousden, KH and Uldrijan, S (2012)
    Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability.
    FEBS Letters 586, 2225-2231 PubMed abstract
  • Dou, H; Buetow, L; Hock, A; Sibbet, GJ; Vousden, KH and Huang, DT (2012)
    Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
    Nature Structural & Molecular Biology 19, 184-192 PubMed abstract
  • Hock, AK and Vousden, KH (2012)
    Tumor suppression by p53: fall of the triumvirate?
    Cell 149, 1183-1185 PubMed abstract
  • Rainero, E; Caswell, PT; Muller, PAJ; Grindlay, J; McCaffrey, MW; Zhang, Q; Wakelam, MJO; Vousden, KH; Graziani, A and Norman, JC (2012)
    Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.
    Journal of Cell Biology 196, 277-295 PubMed abstract
  • Roxburgh, P; Hock, AK; Dickens, MP; Mezna, M; Fischer, PM and Vousden, KH (2012)
    Small molecules that bind the Mdm2 RING stabilize and activate p53.
    Carcinogenesis 33, 791-798 PubMed abstract
  • Tucci, P; Agostini, M; Grespi, F; Markert, EK; Terrinoni, A; Vousden, KH; Muller, PAJ; Dötsch, V; Kehrloesser, S; Sayan, BS; Giaccone, G; Lowe, SW; Takahashi, N; Vandenabeele, P; Knight, RA; Levine, AJ and Melino, G (2012)
    Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.
    Proceedings of the National Academy of Sciences of the United States of America 109, 15312-15317 PubMed abstract
  • Vigneron, AM and Vousden, KH (2012)
    An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence.
    EMBO Journal 31, 471-480 PubMed abstract
  • Vousden, K (2012)
    Karen Vousden: getting the big picture on p53. Interview by Caitlin Sedwick.
    Journal of Cell Biology 198, 148-149 PubMed abstract
  • Cao, Y; DePinho, RA; Ernst, M and Vousden, K (2011)
    Cancer research: past, present and future.
    Nature Reviews Cancer 11, 749-754 PubMed abstract
  • Croft, DR; Crighton, D; Samuel, MS; Lourenco, FC; Munro, J; Wood, J; Bensaad, K; Vousden, KH; Sansom, OJ; Ryan, KM and Olson, MF (2011)
    p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.
    Cell Research 21, 666-682 PubMed abstract
  • Hock, AK; Vigneron, AM; Carter, S; Ludwig, RL and Vousden, KH (2011)
    Regulation of p53 stability and function by the deubiquitinating enzyme USP42.
    EMBO Journal 30, 4921-4930 PubMed abstract
  • Maddocks, ODK and Vousden, KH (2011)
    Metabolic regulation by p53.
    Journal of Molecular Medicine 89, 237-245 PubMed abstract
  • Marshall, C and Vousden, K (2011)
    Genetic and cellular mechanisms of oncogenesis.
    Current Opinion in Genetics & Development 21, 1-3 PubMed abstract
  • Mor, I; Cheung, EC and Vousden, KH (2011)
    Control of glycolysis through regulation of PFK1: old friends and recent additions.
    Cold Spring Harbor Symposia on Quantitative Biology 76, 211-216 PubMed abstract
  • Muller, PAJ; Vousden, KH and Norman, JC (2011)
    p53 and its mutants in tumor cell migration and invasion.
    Journal of Cell Biology 192, 209-218 PubMed abstract
  • Stindt, MH; Carter, S; Vigneron, AM; Ryan, KM and Vousden, KH (2011)
    MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.
    Cell Cycle 10, 3176-3188 PubMed abstract
  • Cheung, EC and Vousden, KH (2010)
    The role of p53 in glucose metabolism.
    Current Opinion in Cell Biology 22, 186-191 PubMed abstract
  • Gottlieb, E and Vousden, KH (2010)
    p53 regulation of metabolic pathways.
    Cold Spring Harbor Perspectives in Biology 2, a001040 PubMed abstract
  • Hock, A and Vousden, KH (2010)
    Regulation of the p53 pathway by ubiquitin and related proteins.
    International Journal of Biochemistry and Cell Biology 42, 1618-1621 PubMed abstract
  • O'Prey, J; Crighton, D; Martin, AG; Vousden, KH; Fearnhead, HO and Ryan, KM (2010)
    p53-mediated induction of Noxa and p53AIP1 requires NFκB.
    Cell Cycle 9, 947-952 PubMed abstract
  • Vigneron, A and Vousden, KH (2010)
    p53 and Mdm2: an auld alliance.
    Cell Cycle 9, 865-866 PubMed abstract
  • Vigneron, A and Vousden, KH (2010)
    p53, ROS and senescence in the control of aging.
    Aging 2, 471-474 PubMed abstract
  • Vigneron, AM; Ludwig, RL and Vousden, KH (2010)
    Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.
    Genes & Development 24, 2430-2439 PubMed abstract
  • Vousden, KH (2010)
    Alternative fuel—another role for p53 in the regulation of metabolism.
    Proceedings of the National Academy of Sciences of the United States of America 107, 7117-7118 PubMed abstract

[Page last updated 1 Oct 2017]

Karen Vousden, Crick Group Leader and Cancer Research UK's chief scientist

KarenĀ Vousden

karen.vousden@crick.ac.uk
+44 (0)20 379 63444