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Breadcrumb Karen Vousden Vousden lab p53 and Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members PublicationsYear published2024 (1)2023 (9)2022 (4)2021 (9)2020 (8)2019 (6)2018 (6)2015 (1) Facet Year publishedResearch topicsCell Biology (42)Metabolism (42)Signalling & Oncogenes (42)Biochemistry & Proteomics (11)Computational & Systems Biology (11)Human Biology & Physiology (11)Tumour Biology (11)Developmental Biology (9)Immunology (9)Infectious Disease (9)Model Organisms (7)Genetics & Genomics (6)Genome Integrity & Repair (6)Chemical Biology & High Throughput (5)Stem Cells (5)Neurosciences (3)Gene Expression (2)Imaging (2)Cell Cycle & Chromosomes (1)Microfabrication & Bioengineering (1)Structural Biology & Biophysics (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (44)Primary research (24)Review (12)Commentary (5)Method (2)Obituary (1) Facet Publication typeJournalNature Communications (4)Cell Death and Differentiation (3)Cell Metabolism (3)Cell Reports (3)Genes and Development (3)Cancer Cell (2)Methods in Molecular Biology (2)Molecular Cell (2)Nature Metabolism (2)Biochimica et Biophysica Acta (1)Cancer & Metabolism (1)Cancer Discovery (1)Current Opinion in Biotechnology (1)Disease Models & Mechanisms (1)EMBO Reports (1)Frontiers in Immunology (1)HemaSphere (1)Journal of Cell Science (1)Journal of Clinical Investigation (1)Journal of molecular cell biology (1)Nature (1)Nature Cancer (1)Nature Chemical Biology (1)Nature Genetics (1)Nature Reviews Cancer (1)Proceedings of the National Academy of Sciences of USA (1)Science advances (1)Science Signaling (1)The Lancet (1) Facet Journal Publications Displaying 1 - 20 of 44Last updated : 29 March 2024 02:26 Recovering from the stress of the COVID-19 pandemic Authors (6) Samantha C Lewis Alexis A Jourdain Brenda A SchulmanKaren Vousden Jacqueline M Fabius Haipeng Liu Molecular Cell Published 4 January 2024 Crick labsKaren VousdenFull details Phenotypic profiling of solute carriers characterizes serine transport in cancer Authors (12)Vassilis Papalazarou Alice C Newman Alejandro Huerta-UribeNathalie Legrave Mattia Falcone Tong Zhang[...] Dimitris Athineos Emma Shanks Karen BlythKaren Vousden Oliver DK Maddocks Nature Metabolism Published 1 December 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsLight MicroscopyHigh Throughput ScreeningFull details The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance Authors (85)Deborah Caswell Philippe Gui Manasi K Mayekar Emily K Law Oriol Pich Chris Bailey[...] Nnennaya Kanu Reuben S HarrisJulian Downward Trever G BivonaCharles Swanton Nature Genetics Published 1 January 2024 Crick labs/ facilitiesKaren VousdenCharles SwantonJulian DownwardExperimental HistopathologyBiological Research FacilityFull details A century of the Warburg effect Authors (11) Craig B ThompsonKaren Vousden Randall S Johnson Willem H Koppenol Helmut Sies Zhimin Lu Lydia WS Finley Christian Frezza Jiyeon Kim Zeping Hu Caroline R Bartman Nature Metabolism Published 1 November 2023 Crick labsKaren VousdenFull details Loss of attachment promotes proline accumulation and excretion in cancer cells Authors (8)Steven PilleyMarc Hennequart Anke VandekeereJulianna BlagihNathalie Legrave Sarah-Maria FendtKaren Vousden Christiaan F Labuschagne Science advances Published 6 September 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis Authors (20)Marc HennequartSteven Pilley Christiaan F Labuschagne Jack CoomesLoic MervantPaul Driscoll[...]Eva Gronroos Eric CheungMariia YunevaCharles SwantonKaren Vousden Cell Reports Published 26 May 2023 Crick labs/ facilitiesMariia YunevaKaren VousdenCharles SwantonMetabolomicsBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity Authors (23) Benjamin J JenkinsJulianna Blagih Fernando M Ponce-Garcia Mary Canavan Nancy Gudgeon Simon Eastham[...] Ursula Fearon Gareth W Jones Linda V Sinclair Emma E Vincent Nicholas Jones Cell Metabolism Published 11 July 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details Apoptotic cell death in disease-Current understanding of the NCCD 2023 Authors (228) Ilio Vitale Federico Pietrocola Emma Guilbaud Stuart A Aaronson John M Abrams Dieter Adam[...] Boris Zhivotovsky Wenzhao Zhou Mauro Piacentini Guido Kroemer Lorenzo Galluzzi Cell Death and Differentiation Published 1 May 2023 Crick labsKaren VousdenBart de Strooper | Lorena ArancibiaFull details The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Reflections on Terri Authors (1)Karen Vousden Genes and Development Published 1 January 2023 Crick labsKaren VousdenFull details B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities Authors (7) Katarina Kluckova Andrew J Clear Annalisa D'Avola Laura Z Rassenti Thomas J Kipps John G GribbenJohn Riches HemaSphere Published 1 June 2022 Crick labsKaren VousdenFull details PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma Authors (17) Annalisa D'AvolaNathalie LegraveMylene Tajan Probir Chakravarty Ryan L Shearer Hamish W King[...]James Macrae John G GribbenDinis CaladoKaren VousdenJohn Riches Journal of Clinical Investigation Published 2 May 2022 Crick labs/ facilitiesKaren VousdenDinis CaladoMetabolomicsBioinformatics and BiostatisticsFull details A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo Authors (12)Tim Humpton Andreas K Hock Christos Kiourtis Marco De Donatis Frédéric Fercoq Colin Nixon[...] Douglas Strathdee Leo M Carlin Thomas G Bird Karen BlythKaren Vousden Science Signaling Published 8 February 2022 Crick labs/ facilitiesKaren VousdenBioinformatics and BiostatisticsFull details The role of ROS in tumour development and progression Authors (2)Eric CheungKaren Vousden Nature Reviews Cancer Published 1 May 2022 Crick labsKaren VousdenFull details A celebration of the life of George Vande Woude Authors (2) Sue VandeWoudeKaren Vousden Proceedings of the National Academy of Sciences of USA Published 7 December 2021 Crick labsKaren VousdenFull details The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells Authors (8)Marc HennequartChristiaan LabuschagneMylene TajanSteven PilleyEric CheungNathalie LegravePaul DriscollKaren Vousden Nature Communications Published 26 October 2021 Crick labs/ facilitiesKaren VousdenMetabolomicsMRC Biomedical NMR CentreFull details p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 Authors (10)Tim Humpton Holly Hall Christos Kiourtis Colin Nixon William Clark Ann Hedley Robin Shaw Thomas G Bird Karen BlythKaren Vousden Cell Death and Differentiation Published 1 March 2022 Crick labsKaren VousdenFull details More Metabolism! Authors (11) James A Olzmann Sarah-Maria Fendt Yatrik ShahKaren Vousden Navdeep Chandel Tiffany Horng Nika Danial Benjamin Tu Heather Christofk Matthew G Vander Heiden Kathryn Wellen Molecular Cell Published 16 September 2021 Crick labsKaren VousdenFull details Tissue nutrient environments and their effect on regulatory T cell biology Authors (3)Julianna BlagihMarc HennequartFabio Zani Frontiers in Immunology Published 1 April 2021 Crick labsKaren VousdenFull details Mutant p53 in cell-cell interactions Authors (3)Steven Pilley Tristan A RodriguezKaren Vousden Genes and Development Published 1 April 2021 Crick labsKaren VousdenFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Recovering from the stress of the COVID-19 pandemic Authors (6) Samantha C Lewis Alexis A Jourdain Brenda A SchulmanKaren Vousden Jacqueline M Fabius Haipeng Liu Molecular Cell Published 4 January 2024 Crick labsKaren VousdenFull details
Phenotypic profiling of solute carriers characterizes serine transport in cancer Authors (12)Vassilis Papalazarou Alice C Newman Alejandro Huerta-UribeNathalie Legrave Mattia Falcone Tong Zhang[...] Dimitris Athineos Emma Shanks Karen BlythKaren Vousden Oliver DK Maddocks Nature Metabolism Published 1 December 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsLight MicroscopyHigh Throughput ScreeningFull details
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance Authors (85)Deborah Caswell Philippe Gui Manasi K Mayekar Emily K Law Oriol Pich Chris Bailey[...] Nnennaya Kanu Reuben S HarrisJulian Downward Trever G BivonaCharles Swanton Nature Genetics Published 1 January 2024 Crick labs/ facilitiesKaren VousdenCharles SwantonJulian DownwardExperimental HistopathologyBiological Research FacilityFull details
A century of the Warburg effect Authors (11) Craig B ThompsonKaren Vousden Randall S Johnson Willem H Koppenol Helmut Sies Zhimin Lu Lydia WS Finley Christian Frezza Jiyeon Kim Zeping Hu Caroline R Bartman Nature Metabolism Published 1 November 2023 Crick labsKaren VousdenFull details
Loss of attachment promotes proline accumulation and excretion in cancer cells Authors (8)Steven PilleyMarc Hennequart Anke VandekeereJulianna BlagihNathalie Legrave Sarah-Maria FendtKaren Vousden Christiaan F Labuschagne Science advances Published 6 September 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details
ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis Authors (20)Marc HennequartSteven Pilley Christiaan F Labuschagne Jack CoomesLoic MervantPaul Driscoll[...]Eva Gronroos Eric CheungMariia YunevaCharles SwantonKaren Vousden Cell Reports Published 26 May 2023 Crick labs/ facilitiesMariia YunevaKaren VousdenCharles SwantonMetabolomicsBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity Authors (23) Benjamin J JenkinsJulianna Blagih Fernando M Ponce-Garcia Mary Canavan Nancy Gudgeon Simon Eastham[...] Ursula Fearon Gareth W Jones Linda V Sinclair Emma E Vincent Nicholas Jones Cell Metabolism Published 11 July 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details
Apoptotic cell death in disease-Current understanding of the NCCD 2023 Authors (228) Ilio Vitale Federico Pietrocola Emma Guilbaud Stuart A Aaronson John M Abrams Dieter Adam[...] Boris Zhivotovsky Wenzhao Zhou Mauro Piacentini Guido Kroemer Lorenzo Galluzzi Cell Death and Differentiation Published 1 May 2023 Crick labsKaren VousdenBart de Strooper | Lorena ArancibiaFull details
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Reflections on Terri Authors (1)Karen Vousden Genes and Development Published 1 January 2023 Crick labsKaren VousdenFull details
B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities Authors (7) Katarina Kluckova Andrew J Clear Annalisa D'Avola Laura Z Rassenti Thomas J Kipps John G GribbenJohn Riches HemaSphere Published 1 June 2022 Crick labsKaren VousdenFull details
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma Authors (17) Annalisa D'AvolaNathalie LegraveMylene Tajan Probir Chakravarty Ryan L Shearer Hamish W King[...]James Macrae John G GribbenDinis CaladoKaren VousdenJohn Riches Journal of Clinical Investigation Published 2 May 2022 Crick labs/ facilitiesKaren VousdenDinis CaladoMetabolomicsBioinformatics and BiostatisticsFull details
A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo Authors (12)Tim Humpton Andreas K Hock Christos Kiourtis Marco De Donatis Frédéric Fercoq Colin Nixon[...] Douglas Strathdee Leo M Carlin Thomas G Bird Karen BlythKaren Vousden Science Signaling Published 8 February 2022 Crick labs/ facilitiesKaren VousdenBioinformatics and BiostatisticsFull details
The role of ROS in tumour development and progression Authors (2)Eric CheungKaren Vousden Nature Reviews Cancer Published 1 May 2022 Crick labsKaren VousdenFull details
A celebration of the life of George Vande Woude Authors (2) Sue VandeWoudeKaren Vousden Proceedings of the National Academy of Sciences of USA Published 7 December 2021 Crick labsKaren VousdenFull details
The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells Authors (8)Marc HennequartChristiaan LabuschagneMylene TajanSteven PilleyEric CheungNathalie LegravePaul DriscollKaren Vousden Nature Communications Published 26 October 2021 Crick labs/ facilitiesKaren VousdenMetabolomicsMRC Biomedical NMR CentreFull details
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 Authors (10)Tim Humpton Holly Hall Christos Kiourtis Colin Nixon William Clark Ann Hedley Robin Shaw Thomas G Bird Karen BlythKaren Vousden Cell Death and Differentiation Published 1 March 2022 Crick labsKaren VousdenFull details
More Metabolism! Authors (11) James A Olzmann Sarah-Maria Fendt Yatrik ShahKaren Vousden Navdeep Chandel Tiffany Horng Nika Danial Benjamin Tu Heather Christofk Matthew G Vander Heiden Kathryn Wellen Molecular Cell Published 16 September 2021 Crick labsKaren VousdenFull details
Tissue nutrient environments and their effect on regulatory T cell biology Authors (3)Julianna BlagihMarc HennequartFabio Zani Frontiers in Immunology Published 1 April 2021 Crick labsKaren VousdenFull details
Mutant p53 in cell-cell interactions Authors (3)Steven Pilley Tristan A RodriguezKaren Vousden Genes and Development Published 1 April 2021 Crick labsKaren VousdenFull details