Non-technical summaries
Intro
Non-technical summaries are an essential element of the Project Licence, and this page contains all the current non-technical summaries for project licences held at the Crick.
Non-technical summaries are published by the Home Office.
The information in the non-technical summary relates to what researchers intend to do for the duration of the project licence, and data on animal numbers and severity are estimates for that research project.
Actual numbers on severity and animals used are published each year for the Crick as a whole.
2018
- Development and Homeostasis of the Enteric Nervous System
- Germinal centre B cells in physiology and pathology
- Identification of determinants of pathology and protection of respiratory infections
- Kinase signalling in neuronal development and function
- Mechanism of stem cell homeostasis, cancer and tissue regeneration
- Mechanisms of activation of unconventional T cells
- p53 pathways in cancer and metabolic diseases
- Regulation of immune response during infection and inflammation in rodents
- Retrovirus-immune system interaction in mice
- Sex chromosomal control of development and disease
- The structure and function of neural circuits underlying information processing in the mammalian brain
2019
- Analysing mechanisms of cancer dissemination and therapy failure
- Dissemination and immune subversion of Toxoplasma gondii
- Establishing PKC-superfamily members as targets for new cancer therapeutics
- Host and bacterial interactions in mycobacterial infections
- Immunology and immunopathology of malaria
- In vivo studies of pathways and cells involved in detecting infection, damage and cancer
- Investigation of Cryptosporidium Host-Pathogen Interactions
- Mechanisms by which lung and pancreatic cancers evade the immune system
- Mechanisms of cancer development
- Mechanisms of normal and leukemic haematopoisesis
- State-dependent neural processing
- Synaptic organisation of neuronal circuits for perception and behaviour
2020
- Cytokine signalling in development and disease
- Development and function of neural circuits underlying perception and behaviour in the mammalian brain
- Development and function of the immune system
- Embryogenesis, stem cells and cell fate decisions
- Environmental influences on immunity and tissue biology
- Genetics of Down Syndrome
- Investigating the pathways regulating tumour progression and regression
- Neutrophils in infection and disease
- The genetics and therapy of skin disease
- The role of DNA damage response and replication factors in genome stability and cancer
- Understanding haematopoietic dynamics in health and disease
2021
- Colony Management, Production & Preservation of GA animals as a service & associated support
- Developmental dynamics of tissue formation
- Dissecting the intrinsic and extrinsic mechanisms regulating normal and leukemic stem cells
- Dissecting Vertebrate Heart Development
- Elucidating the neuroscience aspect of cancer biology to identify novel therapeutics
- Gamma delta T cells and Body surface immunity
- Genetics of sex differentiation
- Human antibody generation platform
- Isolation and propagation of virus in eggs
- Mapping and controlling neural circuits
- Mechanisms of metabolic regulation in health and disease
- Mechanisms regulating neural stem cell activity and neuronal production
- Metabolism as a novel target for cancer therapy
- Neuron-glia biology in neurodegenerative disorders
- Studying host interactions in tumour and metastasis
2022
- Influenza in ferrets
- Neural circuits and immunity in psychosis
- The role of the RASSF family in development and regeneration
- Role of Arp2/3 isoforms in mouse development and tissue homeostasis
- The evolution of the placenta across vertebrates
- Effects of human gene mutations and follicular T cell products on immune responses and disease
- Understanding how metabolism contributes to cancer development, progression and treatment response
