
Adrian Hayday
Principal Group Leader
Adrian Hayday trained as a biochemist, undertook PhD studies in tumour virology and then pursued postdoctoral training at the Massachusetts Institute of Technology (MIT). At MIT he characterised chromosome translocation breakpoints in human B cell lymphomas and contributed to identification of the hitherto unanticipated gamma delta T cell compartment by being the first to describe T cell receptor gamma chain genes.
In 13 years on the faculty at Yale, he helped show that gamma delta T cells illustrate a distinct, unrecognised aspect of lymphocyte biology, including the cells' disproportionate association with tissues rather than with lymphoid organs and their rapid responses to tissue stress.
At a time when tumour immune surveillance was not widely accepted, his lab showed that mice lacking gamma delta T cells are profoundly more susceptible to carcinogens.
His group returned to London in 1998 to establish the Peter Gorer Department of Immunobiology at King's College London. He joined the Cancer Research UK London Research Institute (now part of the Francis Crick Institute) as a joint appointee in 2009.
In recent years, his group has developed a strong programme in human immunology, including clinical trials applying gamma delta T cells in immunotherapy. Among many honours, in 1997 he became the first biologist to win Yale College's most prestigious prize for scholarship, the William Clyde DeVane Medal.
Qualifications and history
Year published
Research topics
- Biochemistry & Proteomics (2)
- Cell Biology (4)
- Cell Cycle & Chromosomes (4)
- Chemical Biology & High Throughput (12)
- Computational & Systems Biology (12)
- Developmental Biology (3)
- Gene Expression (3)
- Genetics & Genomics (13)
- Genome Integrity & Repair (12)
- Human Biology & Physiology (59)
- Imaging (1)
- Immunology (59)
- Infectious Disease (2)
- Model Organisms (59)
- Neurosciences (1)
- Signalling & Oncogenes (1)
- Stem Cells (7)
- Structural Biology & Biophysics (3)
- Tumour Biology (14)
Publication type
Journal
- ACS Chemical Biology (1)
- American Journal of Respiratory Cell and Molecular Biology (1)
- Annals of the New York Academy of Sciences (1)
- Annual Review of Immunology (1)
- Arthritis & Rheumatology (1)
- Biomolecular NMR Assignments (1)
- Biopreservation and Biobanking (1)
- Cancer Causes & Control (2)
- Cancer Cell (2)
- Cancer Immunology Research (2)
- Cancer Research (1)
- Cancer Research Communications (1)
- Cardiovascular Research (1)
- Cell (2)
- Clinical and Experimental Immunology (1)
- Cytometry A (2)
- Developmental Cell (1)
- eLife (1)
- European Journal of Immunology (1)
- Faculty Reviews (1)
- Frontiers in Immunology (4)
- Human Molecular Genetics (1)
- Immunity (5)
- Immunological Reviews (1)
- International Journal of Cancer (1)
- International Journal of Molecular Sciences (1)
- Journal of Allergy and Clinical Immunology (1)
- Journal of Autoimmunity (1)
- Journal of Biological Chemistry (1)
- Journal of Crohns & Colitis (1)
- Journal of Experimental Medicine (1)
- Journal of Immunology (7)
- Journal of Investigative Dermatology (2)
- Journal of Translational Autoimmunity (1)
- Médecine Sciences : M/S (1)
- Methods (1)
- Mucosal Immunology (2)
- Nature Cancer (1)
- Nature Communications (4)
- Nature Genetics (1)
- Nature Immunology (10)
- Nature Medicine (2)
- Nature Reviews Immunology (1)
- PLOS Genetics (1)
- PLOS ONE (2)
- Proceedings of the National Academy of Sciences of the United States of America (4)
- Proceedings of the National Academy of Sciences of USA (3)
- Science (4)
- Science Translational Medicine (3)
- Scientific Reports (1)
- Seminars in Immunology (1)
- The Lancet Oncology (1)
- Transfusion and Apheresis Science (1)
- Trends in Immunology (1)