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Breadcrumb Research A-Z researchers Andrea De Castro PHD Student Downward lab Oncogene Biology Laboratory Year published 2026 (1) 2024 (7) Facet Year published Research topics Immunology (3) Signalling & Oncogenes (2) Tumour Biology (4) Facet Research topics Crick Pre-Crick Crick publications (8) Facet Crick Pre-Crick Publication type Dataset (4) Journal article (4) Primary research (4) Facet Publication type Journal Cancer Research (6) Nature Communications (1) Science advances (1) Facet Journal Displaying 1 - 8 of 8Last updated : 12 August 2026 03:33 KRAS inhibitor induced cancer cell death enhances sensitivity to immune-mediated bystander killing of drug-resistant subclones Authors (15) Mona Tomaschko Kangbo Ng Christopher Moore Claire E Pillsbury Sareena Rana James Campbell [...] Alicia Alonso De la Vega Sophie de Carne Nathan Goehring Miriam Molina Arcas Julian Downward Cancer Research Published 8 June 2026 Crick labs/ facilities Nathan Goehring Julian Downward Experimental Histopathology Bioinformatics and Biostatistics Scientific computing In Vivo Imaging Genomics Flow Cytometry Cell Science Biological Research Facility Full details Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses Authors (22) Megan Cole Panos Anastasiou Claudia Lee Xiaofei Yu Andrea De Castro Jannes Roelink [...] Tanja D de Gruijl Miriam Molina Arcas Charles Swanton Julian Downward Febe VanMaldegem Science advances Published 1 November 2024 Crick labs/ facilities Charles Swanton Julian Downward Electron Microscopy Bioinformatics and Biostatistics Scientific computing Flow Cytometry Biological Research Facility Full details Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade Authors (16) Panos Anastasiou Christopher Moore Sareena Rana Mona Tomaschko Claire E Pillsbury Andrea De Castro [...] Robert Goldstone Jacqueline AM Smith Elsa Quintana Miriam Molina Arcas Julian Downward Nature Communications Published 25 September 2024 Crick labs/ facilities Julian Downward Experimental Histopathology Bioinformatics and Biostatistics Scientific computing Genomics Flow Cytometry Cell Science Biological Research Facility Full details Data from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Figshare Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details Supplementary Table 1 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Figshare Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details Supplementary Table 2 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Zenodo Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details Supplementary Table 3 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Figshare Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details CRISPR-Cas9 screening identifies KRAS-induced COX2 as a driver of immunotherapy resistance in lung cancer Authors (16) Jesse Boumelha Andrea De Castro Nourdine Bah Hongui Cha Sophie de Carne Sareena Rana [...] Phil East Kevin Litchfield Se-Hoon Lee Miriam Molina Arcas Julian Downward Cancer Research Published 15 July 2024 Crick labs/ facilities Julian Downward Bioinformatics and Biostatistics Scientific computing Genomics Flow Cytometry Experimental Histopathology Cell Science Biological Research Facility Full details
KRAS inhibitor induced cancer cell death enhances sensitivity to immune-mediated bystander killing of drug-resistant subclones Authors (15) Mona Tomaschko Kangbo Ng Christopher Moore Claire E Pillsbury Sareena Rana James Campbell [...] Alicia Alonso De la Vega Sophie de Carne Nathan Goehring Miriam Molina Arcas Julian Downward Cancer Research Published 8 June 2026 Crick labs/ facilities Nathan Goehring Julian Downward Experimental Histopathology Bioinformatics and Biostatistics Scientific computing In Vivo Imaging Genomics Flow Cytometry Cell Science Biological Research Facility Full details
Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses Authors (22) Megan Cole Panos Anastasiou Claudia Lee Xiaofei Yu Andrea De Castro Jannes Roelink [...] Tanja D de Gruijl Miriam Molina Arcas Charles Swanton Julian Downward Febe VanMaldegem Science advances Published 1 November 2024 Crick labs/ facilities Charles Swanton Julian Downward Electron Microscopy Bioinformatics and Biostatistics Scientific computing Flow Cytometry Biological Research Facility Full details
Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade Authors (16) Panos Anastasiou Christopher Moore Sareena Rana Mona Tomaschko Claire E Pillsbury Andrea De Castro [...] Robert Goldstone Jacqueline AM Smith Elsa Quintana Miriam Molina Arcas Julian Downward Nature Communications Published 25 September 2024 Crick labs/ facilities Julian Downward Experimental Histopathology Bioinformatics and Biostatistics Scientific computing Genomics Flow Cytometry Cell Science Biological Research Facility Full details
Data from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Figshare Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details
Supplementary Table 1 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Figshare Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details
Supplementary Table 2 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Zenodo Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details
Supplementary Table 3 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Authors (14) Jesse Boumelha Andrea De Castro Nourdine Bah Sophie de Carne Sareena Rana Mona Tomaschko [...] Robert Goldstone Phil East Kevin Litchfield Miriam Molina Arcas Julian Downward Figshare Published 15 July 2024 Crick labs/ facilities Charles Swanton Julian Downward Bioinformatics and Biostatistics Full details
CRISPR-Cas9 screening identifies KRAS-induced COX2 as a driver of immunotherapy resistance in lung cancer Authors (16) Jesse Boumelha Andrea De Castro Nourdine Bah Hongui Cha Sophie de Carne Sareena Rana [...] Phil East Kevin Litchfield Se-Hoon Lee Miriam Molina Arcas Julian Downward Cancer Research Published 15 July 2024 Crick labs/ facilities Julian Downward Bioinformatics and Biostatistics Scientific computing Genomics Flow Cytometry Experimental Histopathology Cell Science Biological Research Facility Full details
