Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Research A Z researchers Ben Davies Head of GeMS Biological Research Facility: Genetic Modification ServiceScience Technology Platform Email Address: Email Year published2024 (3)2023 (1)2022 (1)2021 (1)2019 (1)2013 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (2)Cell Biology (2)Genetics & Genomics (3)Imaging (3)Metabolism (2)Model Organisms (4)Signalling & Oncogenes (2)Stem Cells (1) Facet Research topicsPublication typeJournal article (8) (-)Primary research (8) Facet Publication typeJournalBMC Biology (1)Cell Reports (1)Circulation Research (1)Frontiers in Cell and Developmental Biology (1)Frontiers in Immunology (1)Journal of Clinical Investigation (1)Nature Neuroscience (1)The CRISPR Journal (1) Facet JournalCrick Pre-CrickCrick publications (6)Pre-Crick publications (2) Facet Crick Pre-Crick Displaying 1 - 8 of 8Last updated : 24 April 2024 03:23 Increasing knockin efficiency in mouse zygotes by transient hypothermia Authors (5) Amine Bouchareb Daniel Biggs Samy Alghadban Christopher PreeceBen Davies The CRISPR Journal Published 1 April 2024 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons Authors (40) Carmelo Milioto Mireia Carcolé Ashling Giblin Rachel Coneys Olivia Attrebi Mhoriam Ahmed[...]Ben Davies Marc Aurel Busche Linda Greensmith Elizabeth MC Fisher Adrian M Isaacs Nature Neuroscience Published 1 April 2024 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details Donor template delivery by recombinant adeno-associated virus for the production of knock-in mice Authors (16)Graham DuddyKatherine CourtisJuliette HorwoodJessica OlsenHelen HorslerTina Hodgson[...] Julia Janzen Molly StromIan RosewellKatharine CrawleyBen Davies BMC Biology Published 2 February 2024 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility Authors (13) Katrin Meindl Naomi Issler Sara Afonso Alberto Cebrian-Serrano Karin Müller Christina Sterner[...] Ralph Witzgall Enriko KlootwijkBen Davies Robert Kleta Richard Warth Frontiers in Cell and Developmental Biology Published 12 October 2023 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details A human CD68 promoter-driven inducible cre-recombinase mouse line allows specific targeting of tissue resident macrophages Authors (5) Agata N RumianekBen Davies Keith M Channon David R Greaves Gareth SD Purvis Frontiers in Immunology Published 6 July 2022 Crick labs/ facilitiesGenetic Modification ServiceFull details Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia Authors (11) Aline Jatho Anke Zieseniss Katja Brechtel-Curth Atsushi Yamamoto Mathew L Coleman Ana M Vergel Leon Daniel BiggsBen Davies Chris W PughPeter Ratcliffe Dörthe M Katschinski Circulation Research Published 16 April 2021 Crick labsPeter RatcliffeFull details Systemic silencing of Phd2 causes reversible immune regulatory dysfunction Authors (25) Atsushi Yamamoto Joanna Hester Philip S Macklin Kento Kawai Masateru Uchiyama Daniel Biggs[...] Cheryl L Scudamore Elizabeth Soilleux Fadi IssaPeter Ratcliffe Chris W Pugh Journal of Clinical Investigation Published 3 September 2019 Crick labsPeter RatcliffeFull details A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia Authors (23) Julie Adam Ming Yang Christina Bauerschmidt Mitsuhiro Kitagawa Linda O'Flaherty Pratheesh Maheswaran[...]Peter Ratcliffe Mona El-Bahrawy Houman Ashrafian Tomoyoshi Soga Patrick J Pollard Cell Reports Published 30 May 2013 Crick labsPeter RatcliffeFull details
Increasing knockin efficiency in mouse zygotes by transient hypothermia Authors (5) Amine Bouchareb Daniel Biggs Samy Alghadban Christopher PreeceBen Davies The CRISPR Journal Published 1 April 2024 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons Authors (40) Carmelo Milioto Mireia Carcolé Ashling Giblin Rachel Coneys Olivia Attrebi Mhoriam Ahmed[...]Ben Davies Marc Aurel Busche Linda Greensmith Elizabeth MC Fisher Adrian M Isaacs Nature Neuroscience Published 1 April 2024 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details
Donor template delivery by recombinant adeno-associated virus for the production of knock-in mice Authors (16)Graham DuddyKatherine CourtisJuliette HorwoodJessica OlsenHelen HorslerTina Hodgson[...] Julia Janzen Molly StromIan RosewellKatharine CrawleyBen Davies BMC Biology Published 2 February 2024 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details
A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility Authors (13) Katrin Meindl Naomi Issler Sara Afonso Alberto Cebrian-Serrano Karin Müller Christina Sterner[...] Ralph Witzgall Enriko KlootwijkBen Davies Robert Kleta Richard Warth Frontiers in Cell and Developmental Biology Published 12 October 2023 Crick labs/ facilitiesGenetic Modification ServiceBiological Research FacilityFull details
A human CD68 promoter-driven inducible cre-recombinase mouse line allows specific targeting of tissue resident macrophages Authors (5) Agata N RumianekBen Davies Keith M Channon David R Greaves Gareth SD Purvis Frontiers in Immunology Published 6 July 2022 Crick labs/ facilitiesGenetic Modification ServiceFull details
Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia Authors (11) Aline Jatho Anke Zieseniss Katja Brechtel-Curth Atsushi Yamamoto Mathew L Coleman Ana M Vergel Leon Daniel BiggsBen Davies Chris W PughPeter Ratcliffe Dörthe M Katschinski Circulation Research Published 16 April 2021 Crick labsPeter RatcliffeFull details
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction Authors (25) Atsushi Yamamoto Joanna Hester Philip S Macklin Kento Kawai Masateru Uchiyama Daniel Biggs[...] Cheryl L Scudamore Elizabeth Soilleux Fadi IssaPeter Ratcliffe Chris W Pugh Journal of Clinical Investigation Published 3 September 2019 Crick labsPeter RatcliffeFull details
A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia Authors (23) Julie Adam Ming Yang Christina Bauerschmidt Mitsuhiro Kitagawa Linda O'Flaherty Pratheesh Maheswaran[...]Peter Ratcliffe Mona El-Bahrawy Houman Ashrafian Tomoyoshi Soga Patrick J Pollard Cell Reports Published 30 May 2013 Crick labsPeter RatcliffeFull details