Caetano Reis e Sousa obtained a BSc Hons in Biology in 1989 from Imperial College London, and a DPhil in Immunology in 1992 from the University of Oxford. He subsequently trained as a postdoctoral fellow at the National Institutes of Health, USA, with Ron Germain.
In 1998 he joined the Imperial Cancer Research Fund, later re-named Cancer Research UK London Research Institute, where he headed the Immunobiology Laboratory. His laboratory became part of the Francis Crick Institute in 2015.
He is currently a senior group leader at the Crick and head of the Immunobiology Laboratory. He is also Professor of Immunology in the Department of Medicine at Imperial College London and holds honorary professorships at both University College London (UCL) and King's College London.
Caetano's contributions have been widely recognised and he is included in the list of Highly Cited Researchers (Thomson Reuters) and has won the BD Biosciences Prize of the European Macrophage and Dendritic Cell Society (2002), the Liliane Bettencourt for Life Sciences Award (2008), the Award for Excellence in Basic/Translational Research from the European Society for Clinical Investigation (2011) and the Louis-Jeantet Prize for Medicine (2017).
He is a fellow of The Academy of Medical Sciences (elected 2006), a member of the European Molecular Biology Organisation (EMBO; elected 2006) and was made an Officer of the Order of Sant'Iago da Espada by the government of Portugal, his home country, in 2009.