Cesira De Chiara


Cesira's research interests focus on the study of the mechanisms of antibiotic resistance and allosteric regulation of essential M. tuberculosis enzymes. The research is developed using mechanistic enzymology and structural biology by X-ray crystallography and solution NMR spectroscopy

-She received her MRes in Pharmaceutical Chemistry and Technology in 1992 at the University of Naples (Italy) discussing a thesis on the isolation and identification of marine natural compounds with potential pharmacological activity

- In 1998 she was awarded a PhD in Biochemistry and Biophysics by the University of Padua (Italy) with a thesis on the structural basis of protein thermostability from moderate thermophilic bacteria

- From 1998 to 2001 she did her first Postdoc at the University of Parma (Italy) researching on the structural properties of bioactive peptides

- In 2002 she moved, as a Senior Postdoc, to the Div. of Molecular Structure of NIMR of MRC (London-UK) in the group led by A. Pastore where in 2005 she became Senior Investigator Scientist. As a biophysicist and an NMR spectroscopist, she developped a project investigating the function and the patogenic role of human Ataxin-1 involved in the hereditary disease Spinocerebellar Ataxia type-1

-2013 to date she moved to the Carvalho Lab at NIMR-MRC where in 2015 she became Principal Laboratory Research Scientist at The Francis Crick Institute (London-UK)


Qualifications and history

Uni. of Naples (Italy)
MRes in Pharmaceutical Chemistry and Technology
Uni. of Genoa (Italy)
PhD in Biochemistry and Biophysics
Uni. of Parma (Italy)
Posdoctoral Fellow
MRC-NIMR, London, UK
Senior Postdoctoral Fellow
MRC-NIMR, London, UK
Senior Investigator Scientist
European Molecular Biology Laboratories (EMBL), Germany
Visiting Scientist
Francis Crick Institute
Principal Laboratory Research Scientist
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Last updated : 04 December 2023 03:15