Christine Graham

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

Authors (19)

Lucia Moreira-Teixeira
Olivier Tabone
Christine Graham
Akul Singhania
Evangelos Stavropoulos
Paul S Redford
[...]
Baltazar Cá
Raman Verma
Pranabashis Haldar
Margarida Saraiva
Anne O'Garra

Nature Immunology

Published 1 April 2020

Crick labs/ facilities

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Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Authors (35)

Nature Communications

Published 28 June 2019

Crick labs/ facilities

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A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

Authors (15)

Akul Singhania
Raman Verma
Christine Graham
Jo Lee
Trang Tran
Matthew Richardson
[...]
Karine Kaiser
Marc Rodrigue
Gerrit Woltmann
Pranabashis Haldar
Anne O'Garra

Nature Communications

Published 19 June 2018

Crick labs/ facilities

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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Authors (17)

Jake Dunning
Simon Blankley
Long T Hoang
Mike Cox
Christine Graham
Philip L James
[...]
Peter JM Openshaw
MOSAIC investigators
Alan Hay
John McCauley
Wendy Barclay

Nature Immunology

Published 1 June 2018

Crick labs/ facilities

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Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis

Authors (10)

Hanif Esmail
Rachel Lai
Maia Lesosky
Katalin Wilkinson
Christine Graham
Stuart Horswell
Anna K Coussens
Clifton E Barry
Anne O'Garra
Robert J Wilkinson

Proceedings of the National Academy of Sciences of the United States of America

Published 30 January 2018

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Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

Authors (14)

Jing Wen Lin
Jan Sodenkamp
Deirdre Cunningham
Katrien Deroost
Tshibuayi Christine Tshitenge
Sarah McLaughlin
[...]
Jai Ramesar
Chris J Janse
Christine Graham
Anne O'Garra
Jean Langhorne

Scientific Reports

Published 3 February 2017

Crick labs/ facilities

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The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosis

Authors (14)

Simon Blankley
Christine Graham
Jacob Turner
Matthew PR Berry
Chloe I Bloom
Zhaohui Xu
[...]
Ronan Breen
George Santis
Derek M Blankenship
Marc Lipman
Anne O'Garra

PLOS ONE

Published 5 October 2016

Crick labs

Anne O’Garra

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Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ-glucose positron emission and computed tomography

Authors (16)

Hanif Esmail
Rachel Lai
Maia Lesosky
Katalin Wilkinson
Christine Graham
Anna K Coussens
[...]
JoAnne L Flynn
Douglas B Young
Clifton E Barry III
Anne O'Garra
Robert J Wilkinson

Nature Medicine

Published 1 October 2016

Crick labs

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Differential production of type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages

Authors (11)

Ashleigh Howes
Christina Taubert
Simon Blankley
Natasha Spink
Xuemei Wu
Christine Graham
Jiawen Zhao
Margarida Saraiva
Paola Ricciardi-Castagnoli
Gregory J Bancroft
Anne O'Garra

Journal of Immunology

Published 1 October 2016

Crick labs/ facilities

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A 380-gene meta-signature of active tuberculosis compared with healthy controls

Authors (15)

Simon Blankley
Christine Graham
Joe Levin
Jacob Turner
Matthew PR Berry
Chloe I Bloom
[...]
Ronan Breen
George Santis
Derek M Blankenship
Marc Lipman
Anne O'Garra

European Respiratory Journal

Published 1 June 2016

Crick labs

Anne O’Garra

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Analysis of transcriptional signatures in response to Listeria monocytogenes infection reveals temporal changes that result from type I interferon signaling

Authors (12)

Jonathan M Pitt
Simon Blankley
Krzysztof Potempa
Christine Graham
Lucia Moreira-Teixeira
Finlay W McNab
[...]
Evangelos Stavropoulos
Virginia Pascual
Jacques Banchereau
Damien Chaussabel
Anne O'Garra

PLOS ONE

Published 26 February 2016

Crick labs/ facilities

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HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

Authors (17)

Rachel Lai
Graeme Meintjes
Katalin Wilkinson
Christine Graham
Suzaan Marais
Helen Van der Plas
[...]
Gary Maartens
Jacques Banchereau
Damien Chaussabel
Anne O'Garra
Robert J Wilkinson

Nature Communications

Published 24 September 2015

Crick labs

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The blood transcriptome of experimental melioidosis reflects disease severity and shows considerable similarity with the human disease

Authors (14)

Laura Conejero
Krzysztof Potempa
Christine Graham
Natasha Spink
Simon Blankley
Francisco J Salguero
[...]
Virginia Pascual
Damien Chaussabel
Ganjana Lertmemongkolchai
Anne O'Garra
Gregory J Bancroft

Journal of Immunology

Published 1 October 2015

Crick labs/ facilities

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The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis

Authors (6)

Simon Blankley
Matthew Paul Reddoch Berry
Christine Graham
Chloe I Bloom
Marc Lipman
Anne O'Garra

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Published 19 June 2014

Crick labs

Anne O’Garra

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Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro

Authors (10)

Simon Blankley
Christine Graham
Ashleigh Howes
Chloe I Bloom
Matthew PR Berry
Damien Chaussabel
Virginia Pascual
Jacques Banchereau
Marc Lipman
Anne O'Garra

PLOS ONE

Published 1 January 2014

Crick labs

Anne O’Garra

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Systems approaches to studying the immune response in tuberculosis

Authors (5)

Matthew Paul Reddoch Berry
Simon Blankley
Christine Graham
Chloe I Bloom
Anne O'Garra

Current Opinion in Immunology

Published 7 September 2013

Crick labs

Anne O’Garra

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TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production

Authors (13)

Finlay W McNab
John Ewbank
Ricardo Rajsbaum
Evangelos Stavropoulos
Anna Martirosyan
Paul S Redford
[...]
Margarida Saraiva
Philip Tsichlis
Damien Chaussabel
Steve Ley
Anne O'Garra

Journal of Immunology

Published 1 January 2013

Crick labs/ facilities

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Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers

Authors (28)

Chloe I Bloom
Christine Graham
Matthew PR Berry
Fotini Rozakeas
Paul S Redford
Yuanyuan Wang
[...]
Jacques Banchereau
Virginia Pascual
Ling-Pei Ho
Marc Lipman
Anne O'Garra

PLOS ONE

Published 1 January 2013

Crick labs

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Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy

Authors (14)

Chloe I Bloom
Christine Graham
Matthew PR Berry
Katalin Wilkinson
Tolu Oni
Fotini Rozakeas
[...]
Jacques Banchereau
Virginia Pascual
Marc Lipman
Robert J Wilkinson
Anne O'Garra

PLOS ONE

Published 1 January 2012

Crick labs

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Programmed Death Ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis

Authors (11)

FW McNab
MPR Berry
Christine Graham
SAA Bloch
T Oni
Katalin Wilkinson
Robert J Wilkinson
OM Kon
J Banchereau
D Chaussabel
Anne O'Garra

European Journal of Immunology

Published 20 April 2011

Crick labs

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Christine Graham

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Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosis

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ-glucose positron emission and computed tomography

Differential production of type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages

A 380-gene meta-signature of active tuberculosis compared with healthy controls

Analysis of transcriptional signatures in response to Listeria monocytogenes infection reveals temporal changes that result from type I interferon signaling

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

The blood transcriptome of experimental melioidosis reflects disease severity and shows considerable similarity with the human disease

The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis

Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro

Systems approaches to studying the immune response in tuberculosis

TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production

Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers

Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy

Programmed Death Ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis

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