Clara Correia Melo

I’ve graduated in Pathological Anatomy (Porto – Portugal), followed by a research fellowship at the University of Porto, where I contributed to the molecular understanding of mitotic spindle defects and cancer. Intrigued by the complexity of the cell cycle, coupled to its involvement in cancer and other age-related pathologies, I started a PhD in Molecular Biology of Ageing at Newcastle University (UK), to investigate how mitochondria and pro-inflammatory factors interact during cellular senescence to promote organismal ageing. I then joined the Ralser Lab, as a Post-Doctoral Fellow, aiming to understand the the impact of metabolite exchange on eukaryotic cell ageing and underlying genetic regulation. Both multicellular and unicellular organisms depend on cell-cell interactions for survival and this greatly relies on the exchange of metabolites and proteins to promote optimal fitness and growth. Impairment or inability to metabolically interact drives cellular dysfunction, which accompanies ageing and disease. By integrating ageing assays, genetic and metabolomic analysis in a model of metabolic cooperation in yeast, in single strains or all deletion collections, I aim to: i) investigate the impact of metabolic exchange on cellular ageing, i.e. how metabolite exchange affects cellular ageing and conversely how ageing affects the cell's ability to exchange metabolites and ii) identify novel genetic regulators of metabolite exchange.

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Last updated : 13 July 2020 03:22