Colin Ratcliffe

Postdoctoral Project Research Scientist

Co-culture of cancer cells (darker cells) with stromal fibroblasts (lighter cells) with a signalling molecule shown in green speckles.

Sahai lab

Tumour Cell Biology Laboratory

Qualifications and history

2018

McGill University, Canada

Doctor of Philosophy

Displaying 1 - 11 of 11

Last updated : 10 July 2026 03:03

Multi-Site reproducibility study of 3D high-content analysis with dual-view oblique plane microscopy

Preprint

Authors (24)

Yuriy Alexandrov
Mar Arias-Garcia
Chris Bakal
Eduard Batlle
Vicky Bousgouni
Neil Carragher
[...]
Iain McNeish
Colin Ratcliffe
Erik Sahai
Hugh Sparks
Theresa Suckert

bioRxiv

Published 3 July 2026

Crick labs/ facilities

Full details

Intravital imaging uncovers remodelling of humanised bone marrow-like niches

Preprint

Authors (7)

bioRxiv

Published 26 March 2026

Crick labs

Full details

High content 3D imaging by dual-view oblique plane microscopy

Authors (29)

Hugh Sparks
Leo Rowe-Brown
Yuriy Alexandrov
Nils Gustafsson
Liuba Dvinskikh
Nathan Curry
[...]
Maddy Parsons
Chris Bakal
Neil O Carragher
Erik Sahai
Chris Dunsby

PNAS Nexus

Published 1 December 2025

Crick labs

Erik Sahai

Full details

Imaging-guided platform for real-time intervention in complex in vitro models

Preprint

Authors (15)

Andrea Serio
Sudeep Joshi
Carmen Moreno-Gonzalez
Pacharaporn Suklai
Eugenia Carraro
Colin Ratcliffe
[...]
Thomas Kavanagh
Simon Ameer-beg
Albane Imbert
Erik Sahai
Francesco Saverio Tedesco

Research Square

Published 18 August 2025

Crick labs/ facilities

Full details

VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models

Preprint

Authors (14)

Sudeep Joshi
Carmen Moreno Gonzalez
Pacharaporn Suklai
Eugenia Carraro
Colin Ratcliffe
Giulia Boezio
[...]
Simon Ameer-beg
Albane Imbert
Erik Sahai
Francesco Saverio Tedesco
Andrea Serio

bioRxiv

Published 17 June 2025

Crick labs/ facilities

Full details

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

Preprint

Authors (29)

Colin Ratcliffe
Hugh Sparks
Giulia Boezio
Yuriy Alexandrov
Rob Jenkins
Alix Le Marois
[...]
James Briscoe
Andy Riddell
Simon T Barry
Christopher Dunsby
Erik Sahai

bioRxiv

Published 7 June 2025

Crick labs/ facilities

Full details

Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

Authors (15)

Ioannis Loukas
Fabrizio Simeoni
Marta Milan
Paolo Inglese
Harshil Patel
Robert Goldstone
[...]
Wenhao Tang
Colin Ratcliffe
Erik Sahai
Vahid Shahrezaei
Paola Scaffidi

Cancer Cell

Published 9 January 2023

Crick labs/ facilities

Full details

The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis

Authors (14)

Cedric Tehranian
Laura Fankhauser
Patrick N Harter
Colin Ratcliffe
Pia S Zeiner
Julia M Messmer
[...]
Michael W Ronellenfitsch
Erik Sahai
Wolfgang Wick
Matthia A Karreman
Frank Winkler

Neuro-Oncology

Published 1 February 2022

Crick labs

Erik Sahai

Full details

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

Authors (11)

Manuela Zangrossi
Patrizia Romani
Probir Chakravarty
Colin Ratcliffe
Steven Hooper
Martina Dori
Mattia Forcato
Silvio Bicciato
Sirio Dupont
Erik Sahai
Marco Montagner

Cancers

Published 3 March 2021

Crick labs/ facilities

Full details

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Authors (9)

Hiroshi Kondo
Colin Ratcliffe
Steven Hooper
James Ellis
James MacRae
Marc Hennequart
Christopher W Dunsby
Kurt Anderson
Erik Sahai

Cell Reports

Published 16 February 2021

Crick labs/ facilities

Full details

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Authors (12)

Marco Montagner
Rahul Bhome
Steven Hooper
Probir Chakravarty
Xiao Qin
Jahangir Sufi
[...]
Colin Ratcliffe
Yutaka Naito
Arianna Pocaterra
Christopher J Tape
Erik Sahai

Nature Cell Biology

Published 1 March 2020

Crick labs/ facilities

Full details

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Technical training

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Colin Ratcliffe

Postdoctoral Project Research Scientist

Sahai lab

Qualifications and history

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

Multi-Site reproducibility study of 3D high-content analysis with dual-view oblique plane microscopy

Intravital imaging uncovers remodelling of humanised bone marrow-like niches

High content 3D imaging by dual-view oblique plane microscopy

Imaging-guided platform for real-time intervention in complex in vitro models

VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

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