Dhira Joshi

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans.

Ng KW, Faulkner N, Cornish GH, Rosa A, Harvey R, Hussain S, Ulferts R, Earl C, Wrobel AG, Benton DJ, Roustan C, Bolland W, Thompson R, Agua-Doce A, Hobson P, Heaney J, Rickman H, Paraskevopoulou S, Houlihan CF, Thomson K, Sanchez E, Shin GY, Spyer MJ, Joshi D, O'Reilly N, Walker PA, Kjaer S, Riddell A, Moore C, Jebson BR, Wilkinson M, Marshall LR, Rosser EC, Radziszewska A, Peckham H, Ciurtin C, Wedderburn LR, Beale R, Swanton C, Gandhi S, Stockinger B, McCauley J, Gamblin SJ, McCoy LE, Cherepanov P, Nastouli E, Kassiotis G. Science. 2020 Dec 11;370(6522):1339-1343. doi: 10.1126/science.abe1107. Epub 2020 Nov 6. PMID: 33159009 Free PMC article.

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

McGough IJ, Vecchia L, Bishop B, Malinauskas T, Beckett K, Joshi D, O'Reilly N, Siebold C, Jones EY, Vincent JP. Nature. 2020 Sep;585(7823):85-90. doi: 10.1038/s41586-020-2498-z. Epub 2020 Jul 22. PMID: 32699409 Free PMC article.

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition.

Kelly JR, Martini S, Brownlow N, Joshi D, Federico S, Jamshidi S, Kjaer S, Lockwood N, Rahman KM, Fraternali F, Parker PJ, Soliman TN. Nat Commun. 2020 Mar 13;11(1):1396. doi: 10.1038/s41467-020-15163-6. PMID: 32170202 Free PMC article.

Author Correction: The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition.

Kelly JR, Martini S, Brownlow N, Joshi D, Federico S, Jamshidi S, Kjaer S, Lockwood N, Rahman KM, Fraternali F, Parker PJ, Soliman TN. Nat Commun. 2020 Jun 3;11(1):2884. doi: 10.1038/s41467-020-16468-2. PMID: 32493898 Free PMC article.

VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.

Morini MF, Giampietro C, Corada M, Pisati F, Lavarone E, Cunha SI, Conze LL, O'Reilly N, Joshi D, Kjaer S, George R, Nye E, Ma A, Jin J, Mitter R, Lupia M, Cavallaro U, Pasini D, Calado DP, Dejana E, Taddei A. Circ Res. 2018 Jan 19;122(2):231-245. doi: 10.1161/CIRCRESAHA.117.312392. Epub 2017 Dec 12. PMID: 29233846 Free PMC article.

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization.

Gori I, George R, Purkiss AG, Strohbuecker S, Randall RA, Ogrodowicz R, Carmignac V, Faivre L, Joshi D, Kjær S, Hill CS. Elife. 2021 Jan 8;10:e63545. doi: 10.7554/eLife.63545.

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.

Wirth M, Zhang W, Razi M, Nyoni L, Joshi D, O'Reilly N, Johansen T, Tooze SA, Mouilleron S. Nat Commun. 2019 May 3;10(1):2055. doi: 10.1038/s41467-019-10059-6. PMID: 31053714 Free PMC article.

Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity.

Wirth M, Mouilleron S, Zhang W, Sjøttem E, Princely Abudu Y, Jain A, Lauritz Olsvik H, Bruun JA, Razi M, Jefferies HBJ, Lee R, Joshi D, O'Reilly N, Johansen T, Tooze SA. J Mol Biol. 2021 Jun 25;433(13):166987. doi: 10.1016/j.jmb.2021.166987. Epub 2021 Apr 24. PMID: 33845085 Free PMC article.

An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques.

Joshi D, Milligan JC, Zeisner TU, O'Reilly N, Diffley JFX, Papageorgiou G. RSC Adv. 2021 Jun 8;11(33):20457-20464. doi: 10.1039/d1ra03046a. PMID: 34178310 Free PMC article.

Fluorescent Amino Acid Initiated de novo Cyclic Peptides for the Label-Free Assessment of Cell Permeability*.

Wu Y, Bertran MT, Rowley J, Calder EDD, Joshi D, Walport LJ. ChemMedChem. 2021 Jul 8. doi: 10.1002/cmdc.202100315. Online ahead of print. PMID: 34236771

Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

Hořejší Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW, Smerdon SJ, Boulton SJ. Cell Rep. 2014 Apr 10;7(1):19-26. doi: 10.1016/j.celrep.2014.03.013. Epub 2014 Mar 20. PMID: 24656813 Free PMC article.

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.

Milligan JC, Zeisner TU, Papageorgiou G, Joshi D, Soudy C, Ulferts R, Wu M, Lim CT, Tan KW, Weissmann F, Canal B, Fujisawa R, Deegan T, Nagaraj H, Bineva-Todd G, Basier C, Curran JF, Howell M, Beale R, Labib K, O'Reilly N, Diffley JFX. Biochem J. 2021 Jul 16;478(13):2499-2515. doi: 10.1042/BCJ20210197. PMID: 34198327 Free PMC article.

Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.

Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM. Structure. 2009 Jun 10;17(6):809-22. doi: 10.1016/j.str.2009.03.017. PMID: 19523899

Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity.

Wirth M, Mouilleron S, Zhang W, Sjøttem E, Abudu YP, Jain A, Olsvik HL, Bruun JA, Razi M, Jefferies HBJ, Lee R, Joshi D, O'Reilly N, Johansen T, Tooze SA. J Mol Biol. 2021 Jul 23;433(15):167049. doi: 10.1016/j.jmb.2021.167049. Epub 2021 May 26. PMID: 34052024 No abstract available.

Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).

Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JR, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM. J Biol Chem. 2015 Oct 16;290(42):25275-92. doi: 10.1074/jbc.M115.637207. Epub 2015 Aug 20. PMID: 26296892