Diana Passaro

Diana Passaro started her research career as undergraduate student in Naples (Italy) at the University Federico II, where she worked on SELEX-based selection of RNA aptamers against lung cancer cells (PLoS one, 2011). She next did a PhD in hemato-oncology at the Curie Institute in Orsay (France), where she studied the importance of several signalling pathways in regulating cancer stem cell activity in T-cell leukemia. She explored the intrinsic function of calcineurin/NFAT pathway in T-cell leukemia (Leukemia, 2013), as well as its role in regulating chemokine receptors and interaction with the stroma (Cancer Cell, 2015; Oncoscience, 2015; Immunol Rev, 2016). She followed up on investigating the cross-talk between leukemic cells and the surrounding niche at the Francis Crick in Dominique Bonnet lab. She currently studies the abnormalities associated with the vascular microenvironment in acute myeloid leukemia (Cancer Cell, 2017), as well as the molecular adaptation of different niche components to AML in xenigraft models. She also contributed to develop a novel platform to bioengineer and image subcutaneous 3D organoids (JCI, 2017; J Vis Exp. 2017). She is currently co-leading the pre-clinical part of a project aimed to set up clinical imaging of the vascular abnormalities in leukemia patients, a project supported by the Francis Crick i2i grant scheme in collaboration with the In Vivo imaging facility and Barts Hospital (UK).