Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
PhD student recruitment Applications for the 2023 PhD programme are now open until 12:00 noon (GMT) on Wednesday 22 March 2023
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Breadcrumb Research A Z researchers Doaa Taha Postdoctoral Project Research Scientist Patani lab Human Stem Cells and Neurodegeneration Laboratory Year published2022 (2)2021 (4)2020 (2)2019 (1)2018 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (2)Cell Biology (10)Chemical Biology & High Throughput (1)Computational & Systems Biology (5)Gene Expression (5)Genetics & Genomics (5)Genome Integrity & Repair (1)Imaging (1)Microfabrication & Bioengineering (1)Neurosciences (10)Stem Cells (10)Tumour Biology (5) Facet Research topicsPublication typeJournal article (10)Primary research (9)Review (1) Facet Publication typeJournalBrain (5)Brain Pathology (1)Genome Research (1)Glia (1)Nature Communications (1)Nucleic Acids Research (1) Facet JournalCrick Pre-CrickCrick publications (10) Facet Crick Pre-Crick Displaying 1 - 10 of 10Last updated : 28 March 2023 03:28 Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 1 February 2022 Crick labsRickie PataniFull details Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details Automated and unbiased discrimination of ALS from control tissue at single cell resolution Authors (9)Cathleen HagemannGiulia TyzackDoaa Taha Helen Devine Linda Greensmith Jia NewcombeRickie PataniAndrea Serio Raphaëlle Luisier Brain Pathology Published 1 July 2021 Crick labsAndrea SerioRickie PataniFull details Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective Authors (4)Ben ClarkeDoaa TahaGiulia TyzackRickie Patani Glia Published 1 January 2021 Crick labsRickie PataniFull details Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authors (13) Raphaelle LuisierGiulia Tyzack Claire E HallJamie MitchellHelen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Nature Communications Published 22 May 2018 Crick labsJernej UleRickie PataniNicholas LuscombeFull details
Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 1 February 2022 Crick labsRickie PataniFull details
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details
Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details
Automated and unbiased discrimination of ALS from control tissue at single cell resolution Authors (9)Cathleen HagemannGiulia TyzackDoaa Taha Helen Devine Linda Greensmith Jia NewcombeRickie PataniAndrea Serio Raphaëlle Luisier Brain Pathology Published 1 July 2021 Crick labsAndrea SerioRickie PataniFull details
Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details
Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective Authors (4)Ben ClarkeDoaa TahaGiulia TyzackRickie Patani Glia Published 1 January 2021 Crick labsRickie PataniFull details
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authors (13) Raphaelle LuisierGiulia Tyzack Claire E HallJamie MitchellHelen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Nature Communications Published 22 May 2018 Crick labsJernej UleRickie PataniNicholas LuscombeFull details
