Dorota Gibbins

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

Authors (20)

Science Translational Medicine

Published 24 January 2024

Crick labs/ facilities

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Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome

Authors (13)

ME Serrano
E Kim
Bernard Siow
D Ma
L Rojo
C Simmons
[...]
N Singh
A Strydom
EMC Fisher
Victor Tybulewicz
D Cash

Neurobiology of Disease

Published 1 November 2023

Crick labs/ facilities

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Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Authors (10)

Yushi Redhead
Dorota Gibbins
Eva Lana-Elola
Sheona Watson-Scales
Lisa Dobson
Matthias Krause
Karen J Liu
Elizabeth MC Fisher
Jeremy BA Green
Victor Tybulewicz

Development

Published 15 April 2023

Crick labs

Victor Tybulewicz

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Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Authors (26)

Eva Lana-Elola
Heather Cater
Sheona Watson-Scales
Simon Greenaway
Jennifer Mueller-Winkler
Dorota Gibbins
[...]
Michelle Simon
Ann-Marie Mallon
Sara Wells
Elizabeth MC Fisher
Victor Tybulewicz

Disease Models and Mechanisms

Published 1 October 2021

Crick labs/ facilities

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Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration

Authors (19)

Sheona Watson-Scales
Bernadett Kalmar
Eva Lana-Elola
Dorota Gibbins
Federica La Russa
Frances Wiseman
[...]
Y Eugene Yu
Damaris Bennett
Linda Greensmith
Elizabeth MC Fisher
Victor Tybulewicz

PLOS Genetics

Published 10 May 2018

Crick labs/ facilities

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In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome

Authors (8)

Gaëlle Naert
Valentine Ferré
Emeline Keller
Amy Slender
Dorota Gibbins
Elizabeth MC Fisher
Victor Tybulewicz
Tangui Maurice

Journal of Psychopharmacology

Published 1 February 2018

Crick labs

Victor Tybulewicz

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Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

Authors (12)

Alain D Dekker
Yannick Vermeiren
Christelle Albac
Eva Lana-Elola
Sheona Watson-Scales
Dorota Gibbins
[...]
Debby Van Dam
Elizabeth MC Fisher
Victor Tybulewicz
Marie-Claude Potier
Peter P De Deyn

Neurobiology of Disease

Published 1 September 2017

Crick labs

Victor Tybulewicz

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Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Authors (9)

Eva Lana-Elola
Sheona Watson-Scales
Amy Slender
Dorota Gibbins
Alexandrine Martineau
Charlotte Douglas
Timothy Mohun
Elizabeth MC Fisher
Victor Tybulewicz

eLife

Published 14 January 2016

Crick labs/ facilities

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Dorota Gibbins

BRF Colony Coordinator

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Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration

In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

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