Ellen Knuepfer

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

Authors (7)

PLOS Pathogens

Published 6 September 2019

Crick labs/ facilities

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Divergent roles for the RH5 complex components, CyRPA and RIPR, in human-infective malaria parasites

Authors (16)

Ellen Knuepfer
Katherine E Wright
Surendra Kumar Prajapati
Thomas A Rawlinson
Franziska Mohring
Marion Koch
[...]
Simon J Draper
Anna Rosanans-Urgell
Matthew K Higgins
Jake Baum
Tony Holder

PLOS Pathogens

Published 11 June 2019

Crick labs/ facilities

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Structure-guided identification of resistance breaking antimalarial N‑myristoyltransferase inhibitors

Authors (18)

Anja C Schlott
Stephen Mayclin
Alexandra R Reers
Olivia Coburn-Flynn
Andrew S Bell
Judith Green
[...]
Chun-Wa Chung
Peter J Myler
David A Fidock
Edward W Tate
Tony Holder

Cell Chemical Biology

Published 18 July 2019

Crick labs/ facilities

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Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility

Authors (17)

Judith Green
Richard J Wall
Juha Vahokoski
Noor A Yusuf
Mohd A Mohd Ridzuan
Rebecca R Stanway
[...]
Robert W Moon
Justin Molloy
Inari Kursula
Rita Tewari
Tony Holder

Journal of Biological Chemistry

Published 27 October 2017

Crick labs/ facilities

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Generating conditional gene knockouts in Plasmodium - a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9

Authors (4)

Ellen Knuepfer
Marta Napiorkowska
Christiaan Van Ooij
Tony Holder

Scientific Reports

Published 20 June 2017

Crick labs/ facilities

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The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake

Authors (6)

Emma S Sherling
Ellen Knuepfer
Joseph A Brzostowski
Louis H Miller
Mike Blackman
Christiaan van Ooij

eLife

Published 2 March 2017

Crick labs

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Regulation and essentiality of the StAR-related lipid transfer (START) domain-containing phospholipid transfer protein PFA0210c in malaria parasites

Authors (6)

Ross J Hill
Alessa Ringel
Ellen Knuepfer
Robert W Moon
Mike Blackman
Christiaan van Ooij

Journal of Biological Chemistry

Published 11 November 2016

Crick labs

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Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi

Authors (17)

Robert W Moon
Hazem Sharaf
Claire H Hastings
Yung Shwen Ho
Mridul B Nair
Zineb Rchiad
[...]
Neil Almond
Yee Ling Lau
Arnab Pain
Mike Blackman
Tony Holder

Proceedings of the National Academy of Sciences of the United States of America

Published 28 June 2016

Crick labs

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Binding of Plasmodium falciparum merozoite surface proteins DBLMSP and DBLMSP2 to human immunoglobulin M is conserved amongst broadly diverged sequence variants

Authors (16)

Cécile Crosnier
Zamin Iqbal
Ellen Knuepfer
Sorina Maciuca
Abi Perrin
Gathoni Kamuyu
[...]
Tony Holder
Dominic P Kwiatkowski
Julian C Rayner
Richard J Pleass
Gavin J Wright

Journal of Biological Chemistry

Published 1 July 2016

Crick labs

Tony Holder

Full details

The Plasmodium class XIV myosin, MyoB has a distinct subcellular location in invasive and motile stages of the malaria parasite, and an unusual light chain

Authors (14)

Noor A Yusuf
Judith Green
Richard J Wall
Ellen Knuepfer
Robert W Moon
Christina Schulte-Huxel
[...]
Christopher H Douse
Ernesto Cota
Edward W Tate
Rita Tewari
Tony Holder

Journal of Biological Chemistry

Published 8 May 2015

Crick labs/ facilities

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Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

Authors (11)

Robert Stallmach
Manoli Kavishwar
Chrislaine Withers-Martinez
Fiona Hackett
Christine R Collins
Steven A Howell
Sharon Yeoh
Ellen Knuepfer
Avshalom J Atid
Tony Holder
Mike Blackman

Molecular Microbiology

Published 1 April 2015

Crick labs/ facilities

Full details

Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes

Authors (14)

Carinne Ndjembo Ezougou
Fathia Ben-Rached
David K Moss
Jing-Wen Lin
Sally Black
Ellen Knuepfer
[...]
Chris J Janse
Isabelle Coppens
Hélène Yera
Tony Holder
Gordon Langsley

PLOS ONE

Published 1 January 2014

Crick labs

Tony Holder

Full details

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5

Authors (18)

Alexander D Douglas
Andrew R Williams
Ellen Knuepfer
Joseph J Illingworth
Julie M Furze
Cécile Crosnier
[...]
Richard Shimkets
Julian C Rayner
Tony Holder
Gavin J Wright
Simon J Draper

Journal of Immunology

Published 29 November 2013

Crick labs

Tony Holder

Full details

RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation

Authors (10)

Ellen Knuepfer
Oniz Suleyman
Anton R Dluzewski
Ursula Straschil
Aisling H O'Keeffe
Solabomi Ogun
Judith Green
Munira Grainger
Rita Tewari
Tony Holder

Cellular Microbiology

Published 12 August 2013

Crick labs

Tony Holder

Full details

Inducible knockdown of Plasmodium gene expression using the glmS ribozyme

Authors (8)

Parichat Prommana
Chairat Uthaipibull
Chayaphat Wongsombat
Sumalee Kamchonwongpaisan
Yongyuth Yuthavong
Ellen Knuepfer
Tony Holder
Philip J Shaw

PLOS ONE

Published 1 January 2013

Crick labs

Tony Holder

Full details

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites

Authors (16)

Alfred Amambua-Ngwa
Kevin KA Tetteh
Magnus Manske
Natalia Gomez-Escobar
Lindsay B Stewart
M Elizabeth Deerhake
[...]
Muminatou Jallow
Susana Campino
Bronwyn Macinnis
Dominic P Kwiatkowski
David J Conway

PLOS Genetics

Published 1 January 2012

Crick labs

Tony Holder

Full details

Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development

Authors (6)

Mohd A Mohd Ridzuan
Robert W Moon
Ellen Knuepfer
Sally Black
Tony Holder
Judith Green

PLOS ONE

Published 1 January 2012

Crick labs

Tony Holder

Full details

Targeted disruption of py235ebp-1: Invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein

Authors (9)

Solabomi Ogun
R Tewari
TD Otto
SA Howell
Ellen Knuepfer
Deirdre Cunningham
Z Xu
A Pain
Tony Holder

PLOS Pathogens

Published 1 February 2011

Crick labs/ facilities

Full details

A-Z of research labs

Clinical group leaders

Engaging our community

Family Zone

Coronavirus (COVID-19) research

Francis Crick Institute coronavirus (COVID-19) response

Ellen Knuepfer

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

Divergent roles for the RH5 complex components, CyRPA and RIPR, in human-infective malaria parasites

Structure-guided identification of resistance breaking antimalarial N‑myristoyltransferase inhibitors

Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility

Generating conditional gene knockouts in Plasmodium - a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9

The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake

Regulation and essentiality of the StAR-related lipid transfer (START) domain-containing phospholipid transfer protein PFA0210c in malaria parasites

Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi

Binding of Plasmodium falciparum merozoite surface proteins DBLMSP and DBLMSP2 to human immunoglobulin M is conserved amongst broadly diverged sequence variants

The Plasmodium class XIV myosin, MyoB has a distinct subcellular location in invasive and motile stages of the malaria parasite, and an unusual light chain

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5

RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation

Inducible knockdown of Plasmodium gene expression using the glmS ribozyme

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites

Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development

Targeted disruption of py235ebp-1: Invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein

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