Eva Gronroos

Pervasive chromosomal instability and karyotype order in tumour evolution

Authors (55)

Tom Watkins
Emilia Lim
Marina Petkovic
Sergi Elizalde
Nicolai Birkbak
Gareth Wilson
[...]
Peter Van Loo
Samuel F Bakhoum
Roland F Schwarz
Nicholas McGranahan
Charles Swanton

Nature

Published 5 November 2020

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Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Authors (17)

Nature Communications

Published 14 April 2020

Crick labs/ facilities

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Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses

Authors (16)

Cell Reports

Published 14 January 2020

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Tolerance of chromosomal instability in cancer: Mechanisms and therapeutic opportunities

Authors (2)

Eva Gronroos
Carlos López-García

Cancer Research

Published 12 November 2018

Crick labs

Charles Swanton

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Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal

Authors (71)

Samra Turajlic
Hang Xu
Kevin Litchfield
Andrew Rowan
Stuart Horswell
Tim Chambers
[...]
Peter Van Loo
Peter Campbell
James Larkin
Charles Swanton
TRACERx Renal Consortium

Cell

Published 19 April 2018

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Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Authors (105)

Christopher Abbosh
Nicolai Birkbak
Gareth Wilson
Mariam Jamal-Hanjani
Tudor Constantin
Raheleh Salari
[...]
Jacqui A Shaw
Bernhard G Zimmermann
The TRACERx Consortium
The PEACE Consortium
Charles Swanton

Nature

Published 25 May 2017

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BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer

Authors (23)

Carlos López-Garcia
Laurent Sansregret
Enric Domingo
Nicholas McGranahan
Sebastijan Hobor
Nicolai Birkbak
[...]
Aengus Stewart
Havard Danielsen
Marco Novelli
Ian Tomlinson
Charles Swanton

Cancer Cell

Published 9 January 2017

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Cyclin D mediates tolerance of genome-doubling in cancers with functional p53

Authors (14)

A Crockford
Panos Zalmas
Eva Gronroos
SM Dewhurst
N McGranahan
ME Cuomo
[...]
Sukhveer Kaur Purewal
J Cerveira
H Patel
Matt Renshaw
Charles Swanton

Annals of Oncology

Published 17 November 2016

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RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress

Authors (14)

N Kanu
T Zhang
RA Burrell
A Chakraborty
J Cronshaw
Clive Da Costa
[...]
L Gonzalez
S Sabbioneda
HD Ulrich
Charles Swanton
Axel Behrens

Oncogene

Published 28 July 2016

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Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial

Authors (16)

M Jamal-Hanjani
R A'Hern
Nicolai Birkbak
P Gorman
Eva Gronroos
S Ngang
[...]
P Barrett-Lee
SRD Johnston
J Bliss
R Roylance
Charles Swanton

Annals of Oncology

Published 1 July 2015

Crick labs/ facilities

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SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Authors (29)

N Kanu
Eva Gronroos
P Martinez
RA Burrell
X Yi Goh
J Bartkova
[...]
Aengus Stewart
Z Szallasi
J Larkin
J Bartek
Charles Swanton

Oncogene

Published 12 November 2015

Crick labs/ facilities

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Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

Authors (43)

Elza C de Bruin
Nicholas McGranahan
Richard Mitter
Max Salm
David C Wedge
Lucy Yates
[...]
Zoltan Szallasi
Nik Matthews
Aengus Stewart
Peter Campbell
Charles Swanton

Science

Published 10 October 2014

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Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution

Authors (14)

Sally M Dewhurst
Nicholas McGranahan
Rebecca A Burrell
Andrew Rowan
Eva Gronroos
David Endesfelder
[...]
Robyn L Ward
Nicholas J Hawkins
Zoltan Szallasi
Oliver M Sieber
Charles Swanton

Cancer Discovery

Published 1 February 2014

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Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

Authors (35)

Rosalie Fisher
Stuart Horswell
Andrew Rowan
Maximilian P Salm
Elza C de Bruin
Sakshi Gulati
[...]
Jianing Xu
Lisa Pickering
Martin Gore
James Larkin
Charles Swanton

Genome Biology

Published 1 January 2014

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Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

Authors (13)

Esther Castellano
Clare Sheridan
May Zaw Thin
Emma Nye
Bradley Spencer-Dene
Markus E Diefenbacher
[...]
Miguel M Murillo
Eva Gronroos
François Lassailly
Gordon Stamp
Julian Downward

Cancer Cell

Published 11 November 2013

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Replication stress links structural and numerical cancer chromosomal instability

Authors (21)

Rebecca A Burrell
Sarah E McClelland
David Endesfelder
Petra Groth
Marie-Christine Weller
Nadeem Shaikh
[...]
Axel Behrens
Thomas Helleday
Jiri Bartek
Ian P Tomlinson
Charles Swanton

Nature

Published 28 February 2013

Crick labs/ facilities

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Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes

Authors (6)

Eva Gronroos
Isabel J Kingston
Anassuya Ramachandran
Rebecca A Randall
Pedro Vizán
Caroline Hill

Molecular and Cellular Biology

Published 1 July 2012

Crick labs

Caroline Hill

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Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

Authors (30)

Marco Gerlinger
Andrew Rowan
Stuart Horswell
James Larkin
David Endesfelder
Eva Gronroos
[...]
Martin Gore
Zoltan Szallasi
Julian Downward
P Andrew Futreal
Charles Swanton

New England Journal of Medicine

Published 8 March 2012

Crick labs/ facilities

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Pervasive chromosomal instability and karyotype order in tumour evolution

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses

Tolerance of chromosomal instability in cancer: Mechanisms and therapeutic opportunities

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer

Cyclin D mediates tolerance of genome-doubling in cancers with functional p53

RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress

Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution

Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

Replication stress links structural and numerical cancer chromosomal instability

Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

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