Gareth Wilson

Pervasive chromosomal instability and karyotype order in tumour evolution

Authors (55)

Tom Watkins
Emilia Lim
Marina Petkovic
Sergi Elizalde
Nicolai Birkbak
Gareth Wilson
[...]
Peter Van Loo
Samuel F Bakhoum
Roland F Schwarz
Nicholas McGranahan
Charles Swanton

Nature

Published 2 September 2020

Crick labs/ facilities

Full details

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Authors (51)

Ehsan Ghorani
James L Reading
Jake Y Henry
Marc Robert de Massy
Rachel Rosenthal
Virginia Turati
[...]
Karl S Peggs
Nicholas McGranahan
Benny Chain
Charles Swanton
Sergio A Quezada

Nature Cancer

Published 1 May 2020

Crick labs

Full details

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Authors (17)

Saioa López
Emilia Lim
Stuart Horswell
Kerstin Haase
Ariana Huebner
Michelle Dietzen
[...]
Peter Van Loo
Mariam Jamal-Hanjani
TRACERx Consortium
Charles Swanton
Nicholas McGranahan

Nature Genetics

Published 5 March 2020

Crick labs/ facilities

Full details

A clonal expression biomarker associates with lung cancer mortality

Authors (36)

Dhruva Biswas
Nicolai Birkbak
Rachel Rosenthal
Crispin T Hiley
Emilia Lim
Krisztian Papp
[...]
Zoltan Szallasi
Javier Herrero
Nicholas McGranahan
Charles Swanton
TRACERx Consortium

Nature Medicine

Published 7 October 2019

Crick labs/ facilities

Full details

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Authors (35)

Francesca Chemi
Dominic G Rothwell
Nicholas McGranahan
Sakshi Gulati
Chris Abbosh
Simon P Pearce
[...]
Allan Hackshaw
Ged Brady
Charles Swanton
Caroline Dive
TRACERx Consortium

Nature Medicine

Published 7 October 2019

Crick labs

Charles Swanton

Full details

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Authors (35)

Kroopa Joshi
Marc Robert de Massy
Mazlina Ismail
James L Reading
Imran Uddin
Annemarie Woolston
[...]
Nicholas McGranahan
Charles Swanton
TRACERx Consortium
Sergio A Quezada
Benny Chain

Nature Medicine

Published 7 October 2019

Crick labs

Charles Swanton

Full details

Computational methods for analysis of tumor clonality and evolutionary history

Authors (3)

Gerald Goh
Nicholas McGranahan
Gareth Wilson

Methods in Molecular Biology

Published 1 January 2019

Crick labs

Charles Swanton

Full details

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal

Authors (71)

Samra Turajlic
Hang Xu
Kevin Litchfield
Andrew Rowan
Stuart Horswell
Tim Chambers
[...]
Peter Van Loo
Peter Campbell
James Larkin
Charles Swanton
TRACERx Renal Consortium

Cell

Published 19 April 2018

Crick labs/ facilities

Full details

Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors

Authors (12)

Rob Hynds
Assma Ben Aissa
Kate HC Gowers
Tom Watkins
Leticia Bosshard-Carter
Andrew Rowan
[...]
Gareth Wilson
Sergio A Quezada
Charles Swanton
TRACERx Consortium
Sam M Janes

International Journal of Cancer

Published 1 July 2018

Crick labs

Charles Swanton

Full details

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Authors (36)

Nicholas McGranahan
Andrew JS Furness
Rachel Rosenthal
Sofie Ramskov
Rikke Lyngaa
Sunil Kumar Saini
[...]
Karl S Peggs
Timothy A Chan
Sine R Hadrup
Sergio A Quezada
Charles Swanton

Science

Published 25 March 2016

Crick labs/ facilities

Full details

Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer

Authors (13)

Mariam Jamal-Hanjani
Gareth Wilson
S Horswell
R Mitter
O Sakarya
T Constantin
[...]
S Sigurjonsson
R Pelham
S Kareht
B Zimmermann
Charles Swanton

Annals of Oncology

Published 1 May 2016

Crick labs/ facilities

Full details

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy

Authors (18)

Nirupa Murugaesu
Gareth Wilson
Nicolai Birkbak
Tom Watkins
Nicholas McGranahan
Sacheen Kumar
[...]
Sharmin Begum
Nik Matthews
Daniel Hochhauser
George B Hanna
Charles Swanton

Cancer Discovery

Published 1 August 2015

Crick labs/ facilities

Full details

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Authors (29)

N Kanu
Eva Gronroos
P Martinez
RA Burrell
X Yi Goh
J Bartkova
[...]
Aengus Stewart
Z Szallasi
J Larkin
J Bartek
Charles Swanton

Oncogene

Published 12 November 2015

Crick labs/ facilities

Full details

A-Z of research labs

Clinical group leaders

Engaging our community

Family Zone

Coronavirus (COVID-19) research

Francis Crick Institute coronavirus (COVID-19) response

Gareth Wilson

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

Pervasive chromosomal instability and karyotype order in tumour evolution

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

A clonal expression biomarker associates with lung cancer mortality

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Computational methods for analysis of tumor clonality and evolutionary history

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal

Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

The Francis Crick Institute is a unique partnership between