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Gareth WilsonLab: Cancer Evolution and Genome Instability LaboratoryJob Title: Visiting Scientist Breadcrumb Home Research Researchers Gareth Wilson Year published2020 (3)2019 (4)2018 (2)2017 (2)2016 (2)2015 (2) Facet Year publishedResearch topicsChemical Biology & High Throughput (14)Computational & Systems Biology (14)Developmental Biology (2)Gene Expression (4)Genetics & Genomics (14)Genome Integrity & Repair (14)Human Biology & Physiology (14)Model Organisms (2)Signalling & Oncogenes (14)Tumour Biology (14) Facet Research topicsCrick Pre-CrickCrick publications (15) Facet Crick Pre-CrickPublication typeJournal article (15)Method (1)Primary research (14) Facet Publication typeJournalAnnals of Oncology (2)Cancer Discovery (1)Cell (1)International Journal of Cancer (1)Methods in Molecular Biology (1)Nature (2)Nature Cancer (1)Nature Genetics (1)Nature Medicine (3)Oncogene (1)Science (1) Facet Journal Displaying 1 - 15 of 15Last updated : 24 January 2021 02:06 Pervasive chromosomal instability and karyotype order in tumour evolution Authors (55)Tom WatkinsEmilia Lim Marina Petkovic Sergi ElizaldeNicolai BirkbakGareth Wilson[...]Peter Van Loo Samuel F Bakhoum Roland F Schwarz Nicholas McGranahanCharles Swanton Nature Published 5 November 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeBioinformatics and BiostatisticsScientific computingFull details The T cell differentiation landscape is shaped by tumour mutations in lung cancer Authors (51) Ehsan Ghorani James L Reading Jake Y Henry Marc Robert de MassyRachel Rosenthal Virginia Turati[...] Karl S Peggs Nicholas McGranahan Benny ChainCharles Swanton Sergio A Quezada Nature Cancer Published 1 May 2020 Crick labsPeter Van LooCharles SwantonFull details Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution Authors (17) Saioa LópezEmilia Lim Stuart HorswellKerstin HaaseAriana HuebnerMichelle Dietzen[...]Peter Van Loo Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Genetics Published 5 March 2020 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonGenomics/Equipment ParkBioinformatics and BiostatisticsFull details Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse Authors (35) Francesca Chemi Dominic G Rothwell Nicholas McGranahan Sakshi Gulati Chris Abbosh Simon P Pearce[...] Allan Hackshaw Ged BradyCharles Swanton Caroline Dive TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer Authors (35) Kroopa Joshi Marc Robert de Massy Mazlina Ismail James L Reading Imran Uddin Annemarie Woolston[...] Nicholas McGranahanCharles Swanton TRACERx Consortium Sergio A Quezada Benny Chain Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details Computational methods for analysis of tumor clonality and evolutionary history Authors (3) Gerald Goh Nicholas McGranahanGareth Wilson Methods in Molecular Biology Published 1 January 2019 Crick labsCharles SwantonFull details Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal Authors (71)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Stuart Horswell Tim Chambers[...]Peter Van Loo Peter Campbell James LarkinCharles Swanton TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors Authors (12)Rob Hynds Assma Ben Aissa Kate HC GowersTom Watkins Leticia Bosshard-CarterAndrew Rowan[...]Gareth Wilson Sergio A QuezadaCharles Swanton TRACERx Consortium Sam M Janes International Journal of Cancer Published 1 July 2018 Crick labsCharles SwantonFull details Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters Authors (34) M Linch G GohCrispin Hiley Y Shanmugabavan N McGranahanAndrew Rowan[...] SA Quezada T Marafioti M Gerlinger HU AhmedCharles Swanton Annals of Oncology Published 1 October 2017 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution Authors (105) Christopher AbboshNicolai BirkbakGareth Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari[...] Jacqui A Shaw Bernhard G Zimmermann The TRACERx Consortium The PEACE ConsortiumCharles Swanton Nature Published 25 May 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Authors (36) Nicholas McGranahan Andrew JS FurnessRachel Rosenthal Sofie Ramskov Rikke Lyngaa Sunil Kumar Saini[...] Karl S Peggs Timothy A Chan Sine R Hadrup Sergio A QuezadaCharles Swanton Science Published 25 March 2016 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsFull details Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer Authors (13)Mariam Jamal-HanjaniGareth Wilson S Horswell R Mitter O Sakarya T Constantin[...] S Sigurjonsson R Pelham S Kareht B ZimmermannCharles Swanton Annals of Oncology Published 1 May 2016 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsFull details Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy Authors (18) Nirupa MurugaesuGareth WilsonNicolai BirkbakTom Watkins Nicholas McGranahan Sacheen Kumar[...] Sharmin Begum Nik Matthews Daniel Hochhauser George B HannaCharles Swanton Cancer Discovery Published 1 August 2015 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair Authors (29) N KanuEva Gronroos P Martinez RA Burrell X Yi Goh J Bartkova[...]Aengus Stewart Z Szallasi J Larkin J BartekCharles Swanton Oncogene Published 12 November 2015 Crick labs/ facilitiesCharles SwantonPaul BatesBioinformatics and BiostatisticsAdvanced SequencingFull details
Pervasive chromosomal instability and karyotype order in tumour evolution Authors (55)Tom WatkinsEmilia Lim Marina Petkovic Sergi ElizaldeNicolai BirkbakGareth Wilson[...]Peter Van Loo Samuel F Bakhoum Roland F Schwarz Nicholas McGranahanCharles Swanton Nature Published 5 November 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeBioinformatics and BiostatisticsScientific computingFull details
The T cell differentiation landscape is shaped by tumour mutations in lung cancer Authors (51) Ehsan Ghorani James L Reading Jake Y Henry Marc Robert de MassyRachel Rosenthal Virginia Turati[...] Karl S Peggs Nicholas McGranahan Benny ChainCharles Swanton Sergio A Quezada Nature Cancer Published 1 May 2020 Crick labsPeter Van LooCharles SwantonFull details
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution Authors (17) Saioa LópezEmilia Lim Stuart HorswellKerstin HaaseAriana HuebnerMichelle Dietzen[...]Peter Van Loo Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Genetics Published 5 March 2020 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details
A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonGenomics/Equipment ParkBioinformatics and BiostatisticsFull details
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse Authors (35) Francesca Chemi Dominic G Rothwell Nicholas McGranahan Sakshi Gulati Chris Abbosh Simon P Pearce[...] Allan Hackshaw Ged BradyCharles Swanton Caroline Dive TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer Authors (35) Kroopa Joshi Marc Robert de Massy Mazlina Ismail James L Reading Imran Uddin Annemarie Woolston[...] Nicholas McGranahanCharles Swanton TRACERx Consortium Sergio A Quezada Benny Chain Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details
Computational methods for analysis of tumor clonality and evolutionary history Authors (3) Gerald Goh Nicholas McGranahanGareth Wilson Methods in Molecular Biology Published 1 January 2019 Crick labsCharles SwantonFull details
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal Authors (71)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Stuart Horswell Tim Chambers[...]Peter Van Loo Peter Campbell James LarkinCharles Swanton TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors Authors (12)Rob Hynds Assma Ben Aissa Kate HC GowersTom Watkins Leticia Bosshard-CarterAndrew Rowan[...]Gareth Wilson Sergio A QuezadaCharles Swanton TRACERx Consortium Sam M Janes International Journal of Cancer Published 1 July 2018 Crick labsCharles SwantonFull details
Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters Authors (34) M Linch G GohCrispin Hiley Y Shanmugabavan N McGranahanAndrew Rowan[...] SA Quezada T Marafioti M Gerlinger HU AhmedCharles Swanton Annals of Oncology Published 1 October 2017 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution Authors (105) Christopher AbboshNicolai BirkbakGareth Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari[...] Jacqui A Shaw Bernhard G Zimmermann The TRACERx Consortium The PEACE ConsortiumCharles Swanton Nature Published 25 May 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Authors (36) Nicholas McGranahan Andrew JS FurnessRachel Rosenthal Sofie Ramskov Rikke Lyngaa Sunil Kumar Saini[...] Karl S Peggs Timothy A Chan Sine R Hadrup Sergio A QuezadaCharles Swanton Science Published 25 March 2016 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsFull details
Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer Authors (13)Mariam Jamal-HanjaniGareth Wilson S Horswell R Mitter O Sakarya T Constantin[...] S Sigurjonsson R Pelham S Kareht B ZimmermannCharles Swanton Annals of Oncology Published 1 May 2016 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsFull details
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy Authors (18) Nirupa MurugaesuGareth WilsonNicolai BirkbakTom Watkins Nicholas McGranahan Sacheen Kumar[...] Sharmin Begum Nik Matthews Daniel Hochhauser George B HannaCharles Swanton Cancer Discovery Published 1 August 2015 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair Authors (29) N KanuEva Gronroos P Martinez RA Burrell X Yi Goh J Bartkova[...]Aengus Stewart Z Szallasi J Larkin J BartekCharles Swanton Oncogene Published 12 November 2015 Crick labs/ facilitiesCharles SwantonPaul BatesBioinformatics and BiostatisticsAdvanced SequencingFull details
