2016 to date - Principal Laboratory Research Scientist, Peptide Chemistry, Francis Crick Institute
Design and synthesis of a variety of small molecules as tools for biomedical research including modified amino acids, labelled nucleosides, fluorescent probes etc.
2005-2016 - Senior Investigator Scientist, MRC-NIMR
Synthesis and photochemical evaluation of caged compounds and their applications to neuroscience. Synthesis of ligation auxiliaries for SPPS.
2000-2005 - Senior Research Associate, MRC-NIMR
Synthesis of caged neurotransmitters and other caged compounds for application in smooth muscle and neurophysiological systems.
1994-2000 - Postdoctoral Scientist, MRC-NIMR
Synthesis and characterisation of caged neurotransmitters and technical support in their application.
1992-1994 - Postdoctoral Research Associate, University of Sheffield
Synthesis and characterisation of small molecule models for the active metal centres in multi-copper proteins and enzymes.
- Extensive experience in the design and implementation of multi-step synthesis of complex organic molecules from milligram to multi-gram scale.
- Excellent practical skills in the handling of highly reactive, hygroscopic and photosensitive reagents and performing complex reactions in an inert atmosphere.