George Young

Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

Authors (9)

Nature Genetics

Published 1 December 2020

Crick labs/ facilities

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Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

Authors (5)

Melvyn Yap
George Young
Renata Varnaite
Serge Morand
Jonathan Stoye

PLOS Genetics

Published 11 June 2020

Crick labs

Jonathan Stoye

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Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event

Authors (5)

PLOS Pathogens

Published 26 May 2020

Crick labs/ facilities

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Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Authors (12)

Huipeng Jiao
Laurens Wachsmuth
Snehlata Kumari
Robin Schwarzer
Juan Lin
Remzi Onur Eren
[...]
Rebecca Lane
George Young
George Kassiotis
William J Kaiser
Manolis Pasparakis

Nature

Published 25 March 2020

Crick labs

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Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

Authors (5)

Science advances

Published 1 January 2020

Crick labs

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Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression

Authors (12)

Anastasiya Kazachenka
George Young
Jan Attig
Chrysoula Kordella
Eleftheria Lamprianidou
Emmanuela Zoulia
[...]
Menelaos Papoutselis
Elsa Bernard
Elli Papaemmanuil
Ioannis Kotsianidis
George Kassiotis

Genome Medicine: medicine in the post-genomic era

Published 23 December 2019

Crick labs/ facilities

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Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

Authors (7)

Kevin Ng
Jan Attig
George Young
Eleonora Ottina
Spyros I Papamichos
Ioannis Kotsianidis
George Kassiotis

eLife

Published 15 November 2019

Crick labs/ facilities

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LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly

Authors (9)

Jan Attig
George Young
Lou Hosie
David Perkins
Vesela Encheva-Yokoya
Jonathan Stoye
Bram Snijders
Nicola Ternette
George Kassiotis

Genome Research

Published 1 October 2019

Crick labs/ facilities

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MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells

Authors (8)

Blood

Published 30 January 2019

Crick labs/ facilities

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Evolutionary journey of the retroviral restriction gene Fv1

Authors (5)

George Young
Melvyn Yap
Johan R Michaux
Scott J Steppan
Jonathan Stoye

Proceedings of the National Academy of Sciences of the United States of America

Published 2 October 2018

Crick labs

Jonathan Stoye

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Restoration of endogenous retrovirus infectivity impacts mouse cancer models

Authors (10)

Eleonora Ottina
Prisca Levy
Urszula Eksmond
Julia Merkenschlager
George Young
Juliette Roels
Jonathan Stoye
Thomas Tüting
Dinis Calado
George Kassiotis

Cancer Immunology Research

Published 1 November 2018

Crick labs/ facilities

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The axolotl genome and the evolution of key tissue formation regulators

Authors (19)

Sergej Nowoshilow
Siegfried Schloissnig
Ji-Feng Fei
Andreas Dahl
Andy WC Pang
Martin Pippel
[...]
Han Cao
Bianca Habermann
Michael Hiller
Elly M Tanaka
Eugene W Myers

Nature

Published 1 February 2018

Crick labs

Jonathan Stoye

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The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms

Authors (13)

Markus Alexander Grohme
Siegfried Schloissnig
Andrei Rozanski
Martin Pippel
George Young
Sylke Winkler
[...]
Andreas Dahl
Sean Powell
Michael Hiller
Eugene Myers
Jochen Christian Rink

Nature

Published 1 February 2018

Crick labs

Jonathan Stoye

Full details

Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes

Authors (4)

Frontiers in Microbiology

Published 12 December 2017

Crick labs/ facilities

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HIV-1 infection of primary CD4+ T cells regulates the expression of specific human endogenous retrovirus HERV-K (HML-2) elements

Authors (11)

George Young
Sandra N Terry
Lara Manganaro
Alvaro Cuesta-Dominguez
Gintaras Deikus
Dabeiba Bernal-Rubio
Laura Campisi
Ana Fernandez-Sesma
Robert Sebra
Viviana Simon
Lubbertus CF Mulder

Journal of Virology

Published 1 January 2018

Crick labs

Jonathan Stoye

Full details

Antigenicity of peptides comprising the immunosuppressive domain of the retroviral envelope glycoprotein

Authors (4)

Wellcome Open Research

Published 21 February 2017

Crick labs/ facilities

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Opposing development of cytotoxic and follicular helper CD4 T cells controlled by the TCF-1-Bcl6 nexus

Authors (12)

Tiziano Donnarumma
George Young
Julia Merkenschlager
Urszula Eksmond
Nadine Bongard
Stephen L Nutt
[...]
Ulf Dittmer
Vu Thuy Khanh Le-Trilling
Mirko Trilling
Wibke Bayer
George Kassiotis

Cell Reports

Published 1 November 2016

Crick labs/ facilities

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Dichotomy between T cell and B cell tolerance to neonatal retroviral infection permits T cell therapy

Authors (9)

Bettina Mavrommatis
Lucie Baudino
Prisca Levy
Julia Merkenschlager
Urszula Eksmond
Tiziano Donnarumma
George Young
Jonathan Stoye
George Kassiotis

Journal of Immunology

Published 1 November 2016

Crick labs/ facilities

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Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes

Authors (3)

George Young
Bettina Mavrommatis
George Kassiotis

Retrovirology

Published 25 July 2014

Crick labs

George Kassiotis

Full details

Effective T helper cell responses against retroviruses: are all clonotypes equal?

Authors (3)

Georgina Thorborn
George Young
George Kassiotis

Journal of Leukocyte Biology

Published 15 April 2014

Crick labs

George Kassiotis

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George Young

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Journal

Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression

Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly

MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells

Evolutionary journey of the retroviral restriction gene Fv1

Restoration of endogenous retrovirus infectivity impacts mouse cancer models

The axolotl genome and the evolution of key tissue formation regulators

The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms

Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes

HIV-1 infection of primary CD4+ T cells regulates the expression of specific human endogenous retrovirus HERV-K (HML-2) elements

Antigenicity of peptides comprising the immunosuppressive domain of the retroviral envelope glycoprotein

Opposing development of cytotoxic and follicular helper CD4 T cells controlled by the TCF-1-Bcl6 nexus

Dichotomy between T cell and B cell tolerance to neonatal retroviral infection permits T cell therapy

Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes

Effective T helper cell responses against retroviruses: are all clonotypes equal?

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