Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Research A Z researchers Irene Tumwine POSTDOCTORAL RESEARCH ASSISTANT Langhorne lab Malaria Immunology Laboratory Year published2023 (1)2018 (2)2017 (3)2015 (1) Facet Year publishedResearch topicsCell Biology (1)Developmental Biology (1)Human Biology & Physiology (1)Immunology (6)Infectious Disease (6)Model Organisms (6)Signalling & Oncogenes (1) Facet Research topicsPublication typeJournal article (7)Primary research (7) Facet Publication typeJournalCurrent Research in Immunology (1)EBioMedicine (1)eLife (2)Malaria Journal (1)Nature Microbiology (1)Wellcome Open Research (1) Facet JournalCrick Pre-CrickCrick publications (7) Facet Crick Pre-Crick Displaying 1 - 7 of 7Last updated : 27 March 2023 02:41 Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages Authors (6)Irene TumwineKatrien DeroostPrisca Hill Sarah McLaughlinCaroline HoskingJean Langhorne Current Research in Immunology Published 1 January 2023 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern Authors (9) Jing-Wen Lin Adam J ReidDeirdre Cunningham Ulrike BöhmeIrene Tumwine Sara Keller-Mclaughlin Mandy Sanders Matthew BerrimanJean Langhorne Wellcome Open Research Published 6 December 2018 Crick labsJean LanghorneFull details Plasmodium-specific atypical memory B cells are short-lived activated B cells Authors (10)Damian Mazliah Peter J GardnerEdina Schweighoffer Sarah McLaughlinCaroline HoskingIrene Tumwine Randall S Davis Alexandre J PotocnikVictor TybulewiczJean Langhorne eLife Published 2 November 2018 Crick labs/ facilitiesVictor TybulewiczJean LanghorneFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Follicular helper T cells are essential for the elimination of Plasmodium infection Authors (8) Damián Pérez-Mazliah Minh Phuong NguyenCaroline Hosking Sarah McLaughlinMatthew LewisIrene Tumwine Prisca LevyJean Langhorne EBioMedicine Published 1 October 2017 Crick labs/ facilitiesJean LanghorneFlow CytometryExperimental HistopathologyBiological Research FacilityFull details ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model Authors (9)Deirdre Cunningham Jing-wen Lin Thibaut Brugat William JarraIrene Tumwine Garikai Kushinga Jai Ramesar Blandine Franke-FayardJean Langhorne Malaria Journal Published 3 May 2017 Crick labs/ facilitiesJean LanghorneBiological Research FacilityFull details Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection Authors (18) Thibaut Brugat Adam James Reid Jing-wen LinDeirdre CunninghamIrene Tumwine Garikai Kushinga[...] Oliver Billker Patrick E Duffy Chris Newbold Matthew BerrimanJean Langhorne Nature Microbiology Published 6 February 2017 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization Authors (7) Wiebke Nahrendorf Philip J SpenceIrene Tumwine Prisca Lévy William Jarra Robert W SauerweinJean Langhorne eLife Published 25 February 2015 Crick labsJean LanghorneFull details
Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages Authors (6)Irene TumwineKatrien DeroostPrisca Hill Sarah McLaughlinCaroline HoskingJean Langhorne Current Research in Immunology Published 1 January 2023 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details
Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern Authors (9) Jing-Wen Lin Adam J ReidDeirdre Cunningham Ulrike BöhmeIrene Tumwine Sara Keller-Mclaughlin Mandy Sanders Matthew BerrimanJean Langhorne Wellcome Open Research Published 6 December 2018 Crick labsJean LanghorneFull details
Plasmodium-specific atypical memory B cells are short-lived activated B cells Authors (10)Damian Mazliah Peter J GardnerEdina Schweighoffer Sarah McLaughlinCaroline HoskingIrene Tumwine Randall S Davis Alexandre J PotocnikVictor TybulewiczJean Langhorne eLife Published 2 November 2018 Crick labs/ facilitiesVictor TybulewiczJean LanghorneFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Follicular helper T cells are essential for the elimination of Plasmodium infection Authors (8) Damián Pérez-Mazliah Minh Phuong NguyenCaroline Hosking Sarah McLaughlinMatthew LewisIrene Tumwine Prisca LevyJean Langhorne EBioMedicine Published 1 October 2017 Crick labs/ facilitiesJean LanghorneFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model Authors (9)Deirdre Cunningham Jing-wen Lin Thibaut Brugat William JarraIrene Tumwine Garikai Kushinga Jai Ramesar Blandine Franke-FayardJean Langhorne Malaria Journal Published 3 May 2017 Crick labs/ facilitiesJean LanghorneBiological Research FacilityFull details
Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection Authors (18) Thibaut Brugat Adam James Reid Jing-wen LinDeirdre CunninghamIrene Tumwine Garikai Kushinga[...] Oliver Billker Patrick E Duffy Chris Newbold Matthew BerrimanJean Langhorne Nature Microbiology Published 6 February 2017 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details
Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization Authors (7) Wiebke Nahrendorf Philip J SpenceIrene Tumwine Prisca Lévy William Jarra Robert W SauerweinJean Langhorne eLife Published 25 February 2015 Crick labsJean LanghorneFull details
