Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Vacancies Find links to current vacancies, and information about recruitment to various types of role. Discover job opportunities at the Crick.
Breadcrumb Research A Z researchers Jacob Neeves Postdoctoral Project Research Scientist Patani lab Human Stem Cells and Neurodegeneration Laboratory Year published2023 (2)2022 (1)2021 (2)2019 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (3)Cell Biology (6)Cell Cycle & Chromosomes (1)Chemical Biology & High Throughput (3)Computational & Systems Biology (5)Gene Expression (5)Genetics & Genomics (5)Genome Integrity & Repair (3)Model Organisms (1)Neurosciences (6)Stem Cells (6)Tumour Biology (5) Facet Research topicsPublication typeJournal article (6)Primary research (6) Facet Publication typeJournalBrain (2)Genome Research (1)Nature Communications (1)Neuron (1)Nucleic Acids Research (1) Facet JournalCrick Pre-CrickCrick publications (6) Facet Crick Pre-Crick Displaying 1 - 6 of 6Last updated : 26 September 2023 03:13 Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 21 July 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis Authors (9)Marija Petric HoweHamish CrerarJacob NeevesJasmine HarleyGiulia TyzackPierre Klein Andres RamosRickie Patani Raphaëlle Luisier Genome Research Published 1 October 2022 Crick labsRickie PataniFull details Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 21 July 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis Authors (9)Marija Petric HoweHamish CrerarJacob NeevesJasmine HarleyGiulia TyzackPierre Klein Andres RamosRickie Patani Raphaëlle Luisier Genome Research Published 1 October 2022 Crick labsRickie PataniFull details
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details
Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details
