Jonas Demeulemeester

The clinicogenomic landscape of induction failure in childhood and young adult T-cell acute lymphoblastic leukemia

Authors (18)

David O'Connor
Jonas Demeulemeester
Lucia Conde
Amy Kirkwood
Kent Fung
Foteini Papaleonidopoulou
[...]
Javier Herrero
Peter Van Loo
Anthony V Moorman
Ajay Vora
Marc R Mansour

Journal of Clinical Oncology

Published 1 July 2023

Crick labs

Peter Van Loo

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Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Authors (53)

Takahiro Karasaki
David A Moore
Selvaraju Veeriah
Cristina Naceur-Lombardelli
Antonia Toncheva
Neil Magno
[...]
Andrew G Nicholson
TRACERx Consortium
Nicholas McGranahan
Charles Swanton
Mariam Jamal-Hanjani

Nature Medicine

Published 1 April 2023

Crick labs/ facilities

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Genomic-transcriptomic evolution in lung cancer and metastasis

Authors (47)

Carlos Martínez-Ruiz
James RM Black
Clare Puttick
Mark S Hill
Jonas Demeulemeester
Elizabeth Larose Cadieux
[...]
Peter Van Loo
Mariam Jamal-Hanjani
TRACERx Consortium
Charles Swanton
Nicholas McGranahan

Nature

Published 20 April 2023

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Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression

Authors (40)

Shaolong Cao
Jennifer R Wang
Shuangxi Ji
Peng Yang
Yaoyi Dai
Shuai Guo
[...]
Hongtu Zhu
Alfonso Urbanucci
Jonas Demeulemeester
Peter Van Loo
Wenyi Wang

Nature Biotechnology

Published 1 November 2022

Crick labs

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Biallelic mutations in cancer genomes reveal local mutational determinants

Authors (4)

Jonas Demeulemeester
Stefan C Dentro
Moritz Gerstung
Peter Van Loo

Nature Genetics

Published 1 February 2022

Crick labs

Peter Van Loo

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Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Authors (43)

Eva G Álvarez
Jonas Demeulemeester
Paula Otero
Clemency Jolly
Daniel García-Souto
Ana Pequeño-Valtierra
[...]
Urtzi Garaigorta
Peter J Campbell
Hidewaki Nakagawa
Peter Van Loo
Jose MC Tubio

Nature Communications

Published 25 November 2021

Crick labs

Peter Van Loo

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A pan-cancer landscape of somatic mutations in non-unique regions of the human genome

Authors (6)

Nature Biotechnology

Published 1 December 2021

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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Authors (121)

Stefan C Dentro
Ignaty Leshchiner
Kerstin Haase
Maxime Tarabichi
Jeff Wintersinger
Amit G Deshwar
[...]
Paul T Spellman
David C Wedge
Peter Van Loo
PCAWG Evolution and Heterogeneity Working Group
PCAWG Consortium

Cell

Published 15 April 2021

Crick labs/ facilities

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Pervasive chromosomal instability and karyotype order in tumour evolution

Authors (55)

Tom Watkins
Emilia Lim
Marina Petkovic
Sergi Elizalde
Nicolai Birkbak
Gareth Wilson
[...]
Peter Van Loo
Samuel F Bakhoum
Roland F Schwarz
Nicholas McGranahan
Charles Swanton

Nature

Published 5 November 2020

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Drivers underpinning the malignant transformation of giant cell tumour of bone

Authors (21)

Matthew Fittall
Iben Lyskjaer
Peter Ellery
Patrick Lombard
Jannat Ijaz
Anna-Christina Strobl
[...]
David TW Jones
Nischalan Pillay
Peter Van Loo
Sam Behjati
Adrienne M Flanagan

Journal of Pathology

Published 1 December 2020

Crick labs

Peter Van Loo

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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Authors (1385)

Wei Jiao
Gurnit Atwal
Paz Polak
Rosa Karlic
Edwin Cuppen
Fatima Al-Shahrour
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Communications

Published 5 February 2020

Crick labs

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Combined burden and functional impact tests for cancer driver discovery using DriverPower

Authors (1455)

Shimin Shuai
Federico Abascal
Samirkumar B Amin
Gary D Bader
Pratiti Bandopadhayay
Jonathan Barenboim
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Communications

Published 5 February 2020

Crick labs

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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Authors (1406)

Isidro Cortés-Ciriano
Jake June-Koo Lee
Ruibin Xi
Dhawal Jain
Youngsook L Jung
Lixing Yang
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Genetics

Published 2 March 2020

Crick labs

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Comprehensive molecular characterization of mitochondrial genomes in human cancers

Authors (1341)

Yuan Yuan
Young Seok Ju
Youngwook Kim
Jun Li
Yumeng Wang
Christopher J Yoon
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Genetics

Published 2 March 2020

Crick labs

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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Authors (1405)

Kadir C Akdemir
Victoria T Le
Sahaana Chandran
Yilong Li
Roel G Verhaak
Rameen Beroukhim
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Genetics

Published 2 March 2020

Crick labs

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Divergent mutational processes distinguish hypoxic and normoxic tumours

Authors (1328)

Vinayak Bhandari
Constance H Li
Robert G Bristow
Paul C Boutros
Lauri A Aaltonen
Federico Abascal
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Communications

Published 5 February 2020

Crick labs

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Genomic footprints of activated telomere maintenance mechanisms in cancer

Authors (1413)

Lina Sieverling
Chen Hong
Sandra D Koser
Philip Ginsbach
Kortine Kleinheinz
Barbara Hutter
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Communications

Published 5 February 2020

Crick labs

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Integrative pathway enrichment analysis of multivariate omics data

Authors (1459)

Marta Paczkowska
Jonathan Barenboim
Nardnisa Sintupisut
Natalie S Fox
Helen Zhu
Diala Abd-Rabbo
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Communications

Published 5 February 2020

Crick labs

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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Authors (53)

Bernardo Rodriguez-Martin
Eva G Alvarez
Adrian Baez-Ortega
Jorge Zamora
Fran Supek
Jonas Demeulemeester
[...]
Kathleen H Burns
PCAWG Structural Variation Working Group
Peter J Campbell
Jose MC Tubio
PCAWG Consortium

Nature Genetics

Published 1 March 2020

Crick labs

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Pathway and network analysis of more than 2500 whole cancer genomes

Authors (1453)

Matthew A Reyna
David Haan
Marta Paczkowska
Lieven PC Verbeke
Miguel Vazquez
Abdullah Kahraman
[...]
Nicholas van As
Carolien HM van Deurzen
Marc J van de Vijver
L van’t Veer
Christian von Mering

Nature Communications

Published 5 February 2020

Crick labs

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Research case studies

Vacancies

Cut + Paste exhibition

From local to global: preparing for the next pandemic

About us

Jonas Demeulemeester

VISITING SCIENTIST

Van Loo lab

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Crick Pre-Crick

The clinicogenomic landscape of induction failure in childhood and young adult T-cell acute lymphoblastic leukemia

Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Genomic-transcriptomic evolution in lung cancer and metastasis

Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression

Biallelic mutations in cancer genomes reveal local mutational determinants

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

A pan-cancer landscape of somatic mutations in non-unique regions of the human genome

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Pervasive chromosomal instability and karyotype order in tumour evolution

Drivers underpinning the malignant transformation of giant cell tumour of bone

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Combined burden and functional impact tests for cancer driver discovery using DriverPower

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Comprehensive molecular characterization of mitochondrial genomes in human cancers

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Divergent mutational processes distinguish hypoxic and normoxic tumours

Genomic footprints of activated telomere maintenance mechanisms in cancer

Integrative pathway enrichment analysis of multivariate omics data

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Pathway and network analysis of more than 2500 whole cancer genomes

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