Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Research A Z researchers Julia Greiwe POSTDOCTORAL RESEARCH ASSISTANT Costa lab Macromolecular Machines Laboratory Year published2022 (4)2019 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (5)Cell Biology (3)Cell Cycle & Chromosomes (5)Chemical Biology & High Throughput (2)Computational & Systems Biology (1)Genetics & Genomics (3)Genome Integrity & Repair (5)Imaging (5)Metabolism (1)Model Organisms (3)Structural Biology & Biophysics (5)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (5)Method (1)Primary research (3)Review (1) Facet Publication typeJournalCurrent Opinion in Structural Biology (1)Methods in Enzymology (1)Nature (2)Nature Structural and Molecular Biology (1) Facet JournalCrick Pre-CrickCrick publications (5) Facet Crick Pre-Crick Displaying 1 - 5 of 5Last updated : 27 March 2023 03:40 Mechanism of replication origin melting nucleated by CMG helicase assembly Authors (8)Jacob LewisMarta Gross Joana SousaSarah HenrikusJulia GreiweAndrea NansJohn DiffleyAlessandro Costa Nature Published 30 June 2022 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationFull details ReconSil: An electron microscopy toolbox to study helicase function at an origin of replication Authors (4)Thomas PuehringerJulia GreiweThomas MillerAlessandro Costa Methods in Enzymology Published 5 August 2022 Crick labsAlessandro CostaFull details In silico reconstitution of DNA replication. Lessons from single-molecule imaging and cryo-tomography applied to single-particle cryo-EM Authors (4)Julia Greiwe Giulia ZanettiThomas MillerAlessandro Costa Current Opinion in Structural Biology Published 1 February 2022 Crick labsAlessandro CostaFull details Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM Authors (5)Thomas MillerJulia LockeJulia GreiweJohn DiffleyAlessandro Costa Nature Published 20 November 2019 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationElectron MicroscopyFull details
Mechanism of replication origin melting nucleated by CMG helicase assembly Authors (8)Jacob LewisMarta Gross Joana SousaSarah HenrikusJulia GreiweAndrea NansJohn DiffleyAlessandro Costa Nature Published 30 June 2022 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationFull details
ReconSil: An electron microscopy toolbox to study helicase function at an origin of replication Authors (4)Thomas PuehringerJulia GreiweThomas MillerAlessandro Costa Methods in Enzymology Published 5 August 2022 Crick labsAlessandro CostaFull details
In silico reconstitution of DNA replication. Lessons from single-molecule imaging and cryo-tomography applied to single-particle cryo-EM Authors (4)Julia Greiwe Giulia ZanettiThomas MillerAlessandro Costa Current Opinion in Structural Biology Published 1 February 2022 Crick labsAlessandro CostaFull details
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM Authors (5)Thomas MillerJulia LockeJulia GreiweJohn DiffleyAlessandro Costa Nature Published 20 November 2019 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationElectron MicroscopyFull details
