Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Research A Z researchers Laure Botella SENIOR LABORATORY RESEARCH SCIENTIST Gutierrez lab Host-Pathogen Interactions in Tuberculosis Laboratory Email Address: Email Year published2023 (1)2022 (2)2021 (1) Facet Year publishedResearch topicsCell Biology (4)Infectious Disease (4)Model Organisms (4) Facet Research topicsPublication typeJournal article (4)Primary research (4) Facet Publication typeJournalFEBS Open Bio (1)Journal of Clinical Investigation (1)mBio (1)PLOS Pathogens (1) Facet JournalCrick Pre-CrickCrick publications (4) Facet Crick Pre-Crick Displaying 1 - 4 of 4Last updated : 20 March 2023 03:45 A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages Authors (23) Melissa Bedard Sanne van der NietElliott Bernard Gregory H Babunovic Tan-Yun ChengBeren Aylan[...] Joseph Keane Sho YamasakiMaximiliano Gutierrez Nicole van der Wel D Branch Moody Journal of Clinical Investigation Published 9 February 2023 Crick labsMaximiliano GutierrezFull details High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages Authors (4)Beren AylanLaure BotellaMaximiliano GutierrezPierre Santucci FEBS Open Bio Published 15 December 2022 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyFull details Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis Authors (8)Pierre SantucciBeren AylanLaure BotellaElliott BernardClaudio BussiEnrica PellegrinoNatalia AthanasiadiMaximiliano Gutierrez mBio Published 1 April 2022 Crick labsMaximiliano GutierrezFull details Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation Authors (15)Christophe QuevalTony FearnsLaure Botella Alicia Smyth Laura Schnettger Morgane Mitermite[...] Matthias Trost Dirk Werling Francisco J Salguero Stephen V GordonMaximiliano Gutierrez PLOS Pathogens Published 15 March 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details
A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages Authors (23) Melissa Bedard Sanne van der NietElliott Bernard Gregory H Babunovic Tan-Yun ChengBeren Aylan[...] Joseph Keane Sho YamasakiMaximiliano Gutierrez Nicole van der Wel D Branch Moody Journal of Clinical Investigation Published 9 February 2023 Crick labsMaximiliano GutierrezFull details
High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages Authors (4)Beren AylanLaure BotellaMaximiliano GutierrezPierre Santucci FEBS Open Bio Published 15 December 2022 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyFull details
Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis Authors (8)Pierre SantucciBeren AylanLaure BotellaElliott BernardClaudio BussiEnrica PellegrinoNatalia AthanasiadiMaximiliano Gutierrez mBio Published 1 April 2022 Crick labsMaximiliano GutierrezFull details
Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation Authors (15)Christophe QuevalTony FearnsLaure Botella Alicia Smyth Laura Schnettger Morgane Mitermite[...] Matthias Trost Dirk Werling Francisco J Salguero Stephen V GordonMaximiliano Gutierrez PLOS Pathogens Published 15 March 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details