Lesley Vanes

TACI regulates marginal zone B cell development

Authors (4)

Journal of Experimental Medicine

Published 1 June 2026

Crick labs/ facilities

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PD-L2 regulates natural antibody and IL-10 secretion by B-1 cells

Preprint

Authors (3)

bioRxiv

Published 14 December 2025

Crick labs/ facilities

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WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

Authors (10)

Joshua Biggs O'May
Lesley Vanes
Leon De Boer
David A Lewis
Harald Hartweger
Simone Kunzelmann
Darryl Hayward
Miriam Llorian Sopena
Robert Koechl
Victor Tybulewicz

Nature Communications

Published 21 February 2025

Crick labs/ facilities

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T cell migration requires ion and water influx to regulate actin polymerization

Authors (13)

Leon De Boer
Lesley Vanes
Serena Melgrati
Joshua Biggs O'May
Darryl Hayward
Paul Driscoll
[...]
Renata Magueta
Alexander Morrell
James MacRae
Robert Koechl
Victor Tybulewicz

Nature Communications

Published 6 December 2023

Crick labs/ facilities

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B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice

Authors (11)

Darryl Hayward
Lesley Vanes
Stefanie Wissmann
Sujana Sivapatham
Harald Hartweger
Joshua Biggs O'May
Leon De Boer
Richard Mitter
Robert Koechl
Jens V Stein
Victor Tybulewicz

Journal of Experimental Medicine

Published 6 March 2023

Crick labs/ facilities

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Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival

Authors (8)

Jennifer Mueller-Winkler
Richard Mitter
Julie Rappe
Lesley Vanes
Edina Schweighoffer
Hamid Mohammadi
Andreas Wack
Victor Tybulewicz

Journal of Experimental Medicine

Published 1 February 2021

Crick labs/ facilities

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Critical role of WNK1 in MYC-dependent early mouse thymocyte development

Authors (10)

Robert Koechl
Lesley Vanes
Miriam Llorian Sopena
Probir Chakravarty
Harald Hartweger
Kathryn Fountain
Andrea White
Jennifer Cowan
Graham Anderson
Victor Tybulewicz

eLife

Published 14 October 2020

Crick labs/ facilities

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TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK

Authors (5)

Edina Schweighoffer
Josquin Nys
Lesley Vanes
Nicholas Smithers
Victor Tybulewicz

Journal of Experimental Medicine

Published 1 May 2017

Crick labs/ facilities

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Vav proteins are key regulators of Card9 signaling for innate antifungal immunity

Authors (16)

Susanne Roth
Hanna Bergmann
Martin Jaeger
Assa Yeroslaviz
Konstantin Neumann
Paul-Albert Koenig
[...]
Bianca Habermann
Victor Tybulewicz
Mihai Netea
Xosé R Bustelo
Jürgen Ruland

Cell Reports

Published 6 December 2016

Crick labs

Victor Tybulewicz

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WNK1 kinase balances T cell adhesion versus migration in vivo

Authors (10)

Robert Koechl
Flavian Thelen
Lesley Vanes
Tiago F Brazão
Kathryn Fountain
Jian Xie
Chou-Long Huang
Ruth Lyck
Jens V Stein
Victor Tybulewicz

Nature Immunology

Published 1 September 2016

Crick labs/ facilities

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The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway

Authors (7)

Edina Schweighoffer
Lesley Vanes
Josquin Nys
Doreen Cantrell
Scott McCleary
Nicholas Smithers
Victor Tybulewicz

Immunity

Published 1 January 2013

Crick labs

Victor Tybulewicz

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Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

Authors (13)

S De Vita
C Canzonetta
C Mulligan
F Delom
J Groet
C Baldo
[...]
A Hoischen
J Veltman
EMC Fisher
Victor Tybulewicz
D Nizetic

Oncogene

Published 18 November 2010

Crick labs

Victor Tybulewicz

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Perturbed hematopoiesis in the Tc1 mouse model of Down Syndrome

Authors (9)

Kate Alford
Amy Slender
Lesley Vanes
Zhe Li
Elizabeth MC Fisher
Dean Nizetic
Stuart H Orkin
Irene Roberts
Victor Tybulewicz

Blood

Published 8 April 2010

Crick labs

Victor Tybulewicz

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TACI regulates marginal zone B cell development

PD-L2 regulates natural antibody and IL-10 secretion by B-1 cells

WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

T cell migration requires ion and water influx to regulate actin polymerization

B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice

Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival

Critical role of WNK1 in MYC-dependent early mouse thymocyte development

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK

Vav proteins are key regulators of Card9 signaling for innate antifungal immunity

WNK1 kinase balances T cell adhesion versus migration in vivo

The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway

Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

Perturbed hematopoiesis in the Tc1 mouse model of Down Syndrome

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