Mark Skehel

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

Authors (16)

Imke Ensinck
Alexander Maman
Waleed S Albihlal
Michelangelo Lassandro
Giulia Salzano
Theodora Sideri
[...]
Bram Snijders
Mark Skehel
Ana Casañal
Schraga Schwartz
Folkert Van Werven

eLife

Published 25 July 2023

Crick labs/ facilities

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Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

Authors (10)

Neuron

Published 21 July 2023

Crick labs/ facilities

Full details

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor

Authors (10)

Nature

Published 20 July 2023

Crick labs/ facilities

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Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange

Authors (8)

Molecular Cell

Published 6 July 2023

Crick labs/ facilities

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Bacillus subtilis YtpP and thioredoxin A are new players in the coenzyme-A-mediated defense mechanism against cellular stress

Authors (10)

Maria-Armineh Tossounian
Maria Baczynska
William Dalton
Sew Yeu Peak-Chew
Kipras Undzenas
George Korza
Valeriy Filonenko
Mark Skehel
Peter Setlow
Ivan Gout

Antioxidants

Published 15 April 2023

Crick labs/ facilities

Proteomics

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Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa

Authors (11)

Jan Böhning
Adrian W Dobbelstein
Nina Sulkowski
Kira Eilers
Andriko von Kügelgen
Abul K Tarafder
Sew-Yeu Peak-Chew
Mark Skehel
Vikram Alva
Alain Filloux
Tanmay AM Bharat

PLOS Pathogens

Published 14 April 2023

Crick labs/ facilities

Proteomics

Full details

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Authors (22)

Edgar Gonzalez-Rodriguez
Mia Zol-Hanlon
Ganka Bineva-Todd
Andrea Marchesi
Mark Skehel
Keira E Mahoney
[...]
Robert Wilkinson
Emma C Wall
Ramón Hurtado-Guerrero
Stacy A Malaker
Ben Schumann

ACS Central Science

Published 22 March 2023

Crick labs/ facilities

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Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Authors (14)

Flavia Roşianu
Simeon Mihaylov
Noreen Eder
Antonie Martiniuc
Suzanne Claxton
Helen R Flynn
[...]
Mark Skehel
Bram Snijders
Matthias Krause
Sharon Tooze
Sila Ultanir

Life Science Alliance

Published 1 February 2023

Crick labs/ facilities

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Authors (15)

Molecular Cell

Published 17 November 2022

Crick labs/ facilities

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Cell-specific bioorthogonal tagging of glycoproteins

Authors (31)

Anna Cioce
Bea Calle
Tatiana Rizou
Sarah C Lowery
Vicky Bridgeman
Keira E Mahoney
[...]
Stuart M Haslam
Sabine L Flitsch
Stacy A Malaker
Ilaria Malanchi
Ben Schumann

Nature Communications

Published 25 October 2022

Crick labs/ facilities

Full details

Profiling the site of protein CoAlation and Coenzyme A stabilization interactions

Authors (15)

Maria-Armineh Tossounian
Maria Baczynska
William Dalton
Charlie Newell
Yilin Ma
Sayoni Das
[...]
Sew Yeu Peak-Chew
Mark Skehel
Franca Fraternali
Christine Orengo
Ivan Gout

Antioxidants (Basel)

Published 14 July 2022

Crick labs/ facilities

Proteomics

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Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Authors (43)

Stelios Chrysostomou
Rajat Roy
Filippo Prischi
Lucksamon Thamlikitkul
Kathryn L Chapman
Uwais Mufti
[...]
Julian Downward
Mark Skehel
Maruf MU Ali
Michael J Seckl
Olivier E Pardo

Science Translational Medicine

Published 14 July 2021

Crick labs

Julian Downward

Full details

Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

Authors (14)

Laura C Lehmann
Luka Bacic
Graeme Hewitt
Klaus Brackmann
Anton Sabantsev
Guillaume Gaullier
[...]
Song Tan
Alessandro Costa
Mark Skehel
Simon Boulton
Sebastian Deindl

Cell Reports

Published 22 December 2020

Crick labs

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A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

Authors (17)

Val Pye
Annachiara Rosa
Cinzia Bertelli
Weston B Struwe
Sarah L Maslen
Robin Corey
[...]
Phillip J Stansfeld
Mark Skehel
Carol V Robinson
Massimo Pizzato
Peter Cherepanov

Nature Structural and Molecular Biology

Published 6 January 2020

Crick labs/ facilities

Full details

POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication

Authors (9)

Roberto Bellelli
Ondrej Belan
Val Pye
Camille Clement
Sarah L Maslen
Mark Skehel
Peter Cherepanov
Genevieve Almouzni
Simon Boulton

Molecular Cell

Published 4 October 2018

Crick labs/ facilities

Full details

A NuRD complex from Xenopus laevis eggs is essential for DNA replication during early embryogenesis

Authors (7)

Christo P Christov
Kevin Dingwell
Mark Skehel
Helen S Wilkes
Julian E Sale
Jim Smith
Torsten Krude

Cell Reports

Published 27 February 2018

Crick labs/ facilities

Full details

Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1

Authors (13)

Laura C Lehmann
Graeme Hewitt
Shintaro Aibara
Alexander Leitner
Emil Marklund
Sarah L Maslen
[...]
David van der Spoel
Mark Skehel
Aristidis Moustakas
Simon Boulton
Sebastian Deindl

Molecular Cell

Published 7 December 2017

Crick labs

Simon Boulton

Full details

Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN

Authors (13)

Julian Stingele
Roberto Bellelli
Ferdinand Alte
Graeme Hewitt
Grzegorz Sarek
Sarah L Maslen
[...]
Svend Kjaer
John A Tainer
Mark Skehel
Michael Groll
Simon Boulton

Molecular Cell

Published 17 November 2016

Crick labs/ facilities

Full details

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

Authors (7)

Richard Panayiotou
Francesc Miralles
Rafal Pawlowski
Jessica Diring
Helen R Flynn
Mark Skehel
Richard Treisman

eLife

Published 15 June 2016

Crick labs/ facilities

Full details

The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling

Authors (8)

Ryan D Beveridge
Christopher J Staples
Abhijit A Patil
Katie N Myers
Sarah Maslen
Mark Skehel
Simon Boulton
Spencer J Collis

Cell Cycle

Published 1 November 2014

Crick labs

Simon Boulton

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Research case studies

Vacancies

Cut + Paste exhibition

From local to global: preparing for the next pandemic

About us

Mark Skehel

Head of Proteomics

Proteomics

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Crick Pre-Crick

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor

Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange

Bacillus subtilis YtpP and thioredoxin A are new players in the coenzyme-A-mediated defense mechanism against cellular stress

Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Cell-specific bioorthogonal tagging of glycoproteins

Profiling the site of protein CoAlation and Coenzyme A stabilization interactions

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication

A NuRD complex from Xenopus laevis eggs is essential for DNA replication during early embryogenesis

Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1

Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling

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