Mark Skehel

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Authors (22)

Edgar Gonzalez-Rodriguez
Mia Zol-Hanlon
Ganka Bineva-Todd
Andrea Marchesi
Mark Skehel
Keira E Mahoney
[...]
Robert Wilkinson
Emma C Wall
Ramón Hurtado-Guerrero
Stacy A Malaker
Ben Schumann

ACS Central Science

Published 22 March 2023

Crick labs/ facilities

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Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Authors (14)

Flavia Roşianu
Simeon Mihaylov
Noreen Eder
Antonie Martiniuc
Suzanne Claxton
Helen R Flynn
[...]
Mark Skehel
Bram Snijders
Matthias Krause
Sharon Tooze
Sila Ultanir

Life Sci Alliance

Published 1 February 2023

Crick labs/ facilities

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Authors (15)

Molecular Cell

Published 17 November 2022

Crick labs/ facilities

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Cell-specific bioorthogonal tagging of glycoproteins

Authors (31)

Anna Cioce
Bea Calle
Tatiana Rizou
Sarah C Lowery
Vicky Bridgeman
Keira E Mahoney
[...]
Stuart M Haslam
Sabine L Flitsch
Stacy A Malaker
Ilaria Malanchi
Ben Schumann

Nature Communications

Published 25 October 2022

Crick labs/ facilities

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Profiling the site of protein CoAlation and Coenzyme A stabilization interactions

Authors (15)

Maria-Armineh Tossounian
Maria Baczynska
William Dalton
Charlie Newell
Yilin Ma
Sayoni Das
[...]
Sew Yeu Peak-Chew
Mark Skehel
Franca Fraternali
Christine Orengo
Ivan Gout

Antioxidants (Basel)

Published 14 July 2022

Crick labs/ facilities

Proteomics

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Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Authors (43)

Stelios Chrysostomou
Rajat Roy
Filippo Prischi
Lucksamon Thamlikitkul
Kathryn L Chapman
Uwais Mufti
[...]
Julian Downward
Mark Skehel
Maruf MU Ali
Michael J Seckl
Olivier E Pardo

Science Translational Medicine

Published 14 July 2021

Crick labs

Julian Downward

Full details

Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

Authors (14)

Laura C Lehmann
Luka Bacic
Graeme Hewitt
Klaus Brackmann
Anton Sabantsev
Guillaume Gaullier
[...]
Song Tan
Alessandro Costa
Mark Skehel
Simon Boulton
Sebastian Deindl

Cell Reports

Published 22 December 2020

Crick labs

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A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

Authors (17)

Val Pye
Annachiara Rosa
Cinzia Bertelli
Weston B Struwe
Sarah L Maslen
Robin Corey
[...]
Phillip J Stansfeld
Mark Skehel
Carol V Robinson
Massimo Pizzato
Peter Cherepanov

Nature Structural and Molecular Biology

Published 6 January 2020

Crick labs/ facilities

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POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication

Authors (9)

Roberto Bellelli
Ondrej Belan
Val Pye
Camille Clement
Sarah L Maslen
Mark Skehel
Peter Cherepanov
Genevieve Almouzni
Simon Boulton

Molecular Cell

Published 4 October 2018

Crick labs/ facilities

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A NuRD complex from Xenopus laevis eggs is essential for DNA replication during early embryogenesis

Authors (7)

Christo P Christov
Kevin Dingwell
Mark Skehel
Helen S Wilkes
Julian E Sale
Jim Smith
Torsten Krude

Cell Reports

Published 27 February 2018

Crick labs/ facilities

Full details

Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1

Authors (13)

Laura C Lehmann
Graeme Hewitt
Shintaro Aibara
Alexander Leitner
Emil Marklund
Sarah L Maslen
[...]
David van der Spoel
Mark Skehel
Aristidis Moustakas
Simon Boulton
Sebastian Deindl

Molecular Cell

Published 7 December 2017

Crick labs

Simon Boulton

Full details

Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN

Authors (13)

Julian Stingele
Roberto Bellelli
Ferdinand Alte
Graeme Hewitt
Grzegorz Sarek
Sarah L Maslen
[...]
Svend Kjaer
John A Tainer
Mark Skehel
Michael Groll
Simon Boulton

Molecular Cell

Published 17 November 2016

Crick labs/ facilities

Full details

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

Authors (7)

Richard Panayiotou
Francesc Miralles
Rafal Pawlowski
Jessica Diring
Helen R Flynn
Mark Skehel
Richard Treisman

eLife

Published 15 June 2016

Crick labs/ facilities

Full details

The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling

Authors (8)

Ryan D Beveridge
Christopher J Staples
Abhijit A Patil
Katie N Myers
Sarah Maslen
Mark Skehel
Simon Boulton
Spencer J Collis

Cell Cycle

Published 1 November 2014

Crick labs

Simon Boulton

Full details

Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability

Authors (13)

Christopher J Staples
Katie N Myers
Ryan DD Beveridge
Abhijit A Patil
Anna E Howard
Giancarlo Barone
[...]
Michael Howell
Sarah Maslen
Mark Skehel
Simon Boulton
Spencer J Collis

Journal of Cell Science

Published 1 July 2014

Crick labs/ facilities

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Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex

Authors (10)

Zuzana Hořejší
Lasse Stach
Thomas G Flower
Dhira Joshi
Helen Flynn
Mark Skehel
Nicola O'Reilly
Roksana Ogrodowicz
Stephen J Smerdon
Simon Boulton

Cell Reports

Published 18 March 2014

Crick labs/ facilities

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HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

Authors (14)

Carrie A Adelman
Rafal L Lolo
Nicolai Birkbak
Olga Murina
Kenichiro Matsuzaki
Zuzana Horejsi
[...]
Gordon Stamp
Alan D'Andrea
Alessandro A Sartori
Charles Swanton
Simon Boulton

Nature

Published 17 October 2013

Crick labs/ facilities

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Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation

Authors (5)

Clare C Davies
Atanu Chakraborty
Markus E Diefenbacher
Mark Skehel
Axel Behrens

EMBO Journal

Published 29 May 2013

Crick labs

Axel Behrens

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A role for the RNA pol II–associated PAF complex in AID-induced immune diversification

Authors (13)

Katharina L Willmann
Sara Milosevic
Siim Pauklin
Kerstin-Maike Schmitz
Gopinath Rangam
Maria T Simon
[...]
Isabelle Robert
Vincent Heyer
Ebe Schiavo
Bernardo Reina-San-Martin
Svend K Petersen-Mahrt

Journal of Experimental Medicine

Published 22 October 2012

Full details

MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism

Authors (6)

Kerstin Gari
Ana María León Ortiz
Valérie Borel
Helen Flynn
Mark Skehel
Simon Boulton

Science

Published 13 July 2012

Crick labs/ facilities

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PhD student recruitment

Cut + Paste exhibition

Coronavirus (COVID-19) research

About us

Mark Skehel

Head of Proteomics

Proteomics

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Crick Pre-Crick

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Cell-specific bioorthogonal tagging of glycoproteins

Profiling the site of protein CoAlation and Coenzyme A stabilization interactions

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication

A NuRD complex from Xenopus laevis eggs is essential for DNA replication during early embryogenesis

Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1

Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling

Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability

Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation

A role for the RNA pol II–associated PAF complex in AID-induced immune diversification

MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism

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