My most recent position was as the MND Association Lady Edith Wolfson Senior Non-Clinical Fellow at the Institute of Neurology, UCL and the Francis Crick Institute, where I am currently an independent post-doctoral Fellow. I began my scientific career during my postgraduate work at the University of Vienna, and subsequently during a Post-doctoral post in Department of Biochemistry in Cambridge with the main objective to uncover how our genetic information is amplified by combinatorial mechanisms called ‘alternative splicing’ and ‘RNA editing’. There I developed a strong background in molecular and RNA biology and global transcriptome analysis. At the University of Oxford I investigated how non-coding RNAs shape cell function, particularly in neurons affected in Parkinson’s disease.
My current research investigates how deregulated RNA metabolism contributes to the earliest events in the molecular pathogenesis of motor neurone disease (MND) and how we can modulate this for therapeutic interventions. By applying high-throughput methods like iCLIP (cross-linking Immuno-precipitation), RNAseq and proteomics, I investigate the central role of RNA-protein condensates in MND. The concentration of biopolymers via condensation is fundamental to cellular organisation and physiology, and my research focusses on its effect on gene regulation. I am particularly interested how the altered condensation properties of the RNA-binding protein TDP-43, which is central to MND pathology, contribute to altered RNA metabolism in cell lines and in vitro.
MND Association Lady Edith Wolfson Senior Non-Clinical Fellowship 2016- 2020
Fulford Junior Research Fellowship at Somerville College, Oxford Oct 2012 - Sept 2014
Parkinson’s UK Innovation grant 2012-2014
OSCI seed funding award (Co-applicant) August 2011 – July 2012