Melvyn Yap

Human-like APOBEC3 gene expression and anti-viral responses following replacement of mouse Apobec3 with the 7-gene human APOBEC3 locus

Preprint

Authors (17)

Nerissa K Kirkwood
Haydn M Prosser
Melvyn Yap
Jane Gibson
Ross Cook
Ian Reddin
[...]
James Scott
Kate Bishop
Simak Ali
Allan Bradley
Tim R Fenton

bioRxiv

Published 30 July 2024

Crick labs

Kate Bishop

Full details

HIV-1 Vpr causes separate cell cycle arrests in G2 and M that activate alternative DNA damage pathways

Preprint

Authors (8)

Ross Hall
Lucy Ahern
Melvyn Yap
Chloe Tsai
Virginie C Boucherit
Tohru Takaki
Simon Boulton
Kate Bishop

bioRxiv

Published 2 April 2024

Crick labs

Full details

SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

Authors (7)

Ross Hall
Anabel Guedan
Melvyn Yap
George Young
Ruth Harvey
Jonathan P Stoye
Kate Bishop

PLOS Pathogens

Published 25 August 2022

Crick labs/ facilities

Full details

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

The Lancet

Published 25 July 2020

Crick labs/ facilities

Full details

Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

Authors (5)

Melvyn Yap
George Young
Renata Varnaite
Serge Morand
Jonathan P Stoye

PLOS Genetics

Published 11 June 2020

Crick labs

Jonathan Stoye

Full details

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins

Authors (8)

Jeremy R Keown
Moyra M Black
Aaron Ferron
Melvyn Yap
Michael J Barnett
F Grant Pearce
Jonathan P Stoye
David C Goldstone

Journal of Biological Chemistry

Published 23 November 2018

Crick labs

Jonathan Stoye

Full details

Evolutionary journey of the retroviral restriction gene Fv1

Authors (5)

George Young
Melvyn Yap
Johan R Michaux
Scott J Steppan
Jonathan P Stoye

Proceedings of the National Academy of Sciences of the United States of America

Published 2 October 2018

Crick labs

Jonathan Stoye

Full details

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells

Authors (9)

Paula Ordonez Suarez
Simone Kunzelmann
Harriet CT Groom
Melvyn Yap
Simon Weising
Chris Meier
Kate Bishop
Ian Taylor
Jonathan P Stoye

Scientific Reports

Published 21 February 2017

Crick labs/ facilities

Full details

Expression levels of Fv1: effects on retroviral restriction specificities

Authors (4)

Wilson Li
Melvyn Yap
Vicky Voss
Jonathan P Stoye

Retrovirology

Published 24 June 2016

Crick labs

Jonathan Stoye

Full details

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

Authors (11)

David C Goldstone
Philip Walker
Lesley Calder
Peter J Coombs
Joshua Kirkpatrick
Neil J Ball
Laura Hilditch
Melvyn Yap
Peter Rosenthal
Jonathan P Stoye
Ian Taylor

Proceedings of the National Academy of Sciences of the United States of America

Published 1 July 2014

Crick labs/ facilities

Full details

Evolution of the retroviral restriction gene Fv1: inhibition of non-MLV retroviruses

Authors (4)

Melvyn Yap
Emily Colbeck
Scott A Ellis
Jonathan P Stoye

PLOS Pathogens

Published 1 March 2014

Crick labs

Jonathan Stoye

Full details

Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αs

Authors (2)

Melvyn Yap
Jonathan P Stoye

Philosophical Transactions of the Royal Society B: Biological Sciences

Published 19 September 2013

Crick labs

Jonathan Stoye

Full details

A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid

Authors (11)

DC Goldstone
TG Flower
NJ Ball
M Sanz-Ramos
Melvyn Yap
Roksana Ogrodowicz
N Stanke
J Reh
D Lindemann
JP Stoye
Ian Taylor

PLOS Pathogens

Published 1 May 2013

Crick labs/ facilities

Full details

TRIM proteins and the innate immune response to viruses

Authors (2)

Melvyn Yap
Jonathan P Stoye

Advances in Experimental Medicine and Biology

Published 5 March 2013

Crick labs

Jonathan Stoye

Full details

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

Authors (15)

DC Goldstone
V Ennis-Adeniran
JJ Hedden
HCT Groom
GI Rice
E Christodoulou
[...]
Luiz Pedro Carvalho
JP Stoye
YJ Crow
Ian Taylor
M Webb

Nature

Published 6 November 2011

Crick labs/ facilities

Full details

Unique spectrum of activity of prosimian TRIM5α against exogenous and endogenous retroviruses

Authors (11)

N Rahm
Melvyn Yap
J Snoeck
V Zoete
M Munoz
U Radespiel
E Zimmermann
O Michielin
JP Stoye
A Ciuffi
A Telenti

Journal of Virology

Published 1 May 2011

Crick labs

Jonathan Stoye

Full details

Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein

Authors (6)

Sadayuki Ohkura
David C Goldstone
Melvyn Yap
Kate Holden-Dye
Ian Taylor
Jonathan P Stoye

PLOS Pathogens

Published 1 March 2011

Crick labs

Full details

Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface

Authors (8)

David C Goldstone
Melvyn Yap
Laura E Robertson
Lesley F Haire
William R Taylor
Aris Katzourakis
Jonathan P Stoye
Ian Taylor

Cell Host and Microbe

Published 16 September 2010

Crick labs

Full details

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors

Authors (5)

Harriet CT Groom
Melvyn Yap
Rui Pedro Galão
Stuart JD Neil
Kate Bishop

Proceedings of the National Academy of Sciences of the United States of America

Published 16 March 2010

Crick labs

Kate Bishop

Full details

Research partnerships

Technical training

We Go Way Back

About us

The Crick magazine

Melvyn Yap

Principal Laboratory Research Scientist

Bishop lab

Qualifications and history

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

Human-like APOBEC3 gene expression and anti-viral responses following replacement of mouse Apobec3 with the 7-gene human APOBEC3 locus

HIV-1 Vpr causes separate cell cycle arrests in G2 and M that activate alternative DNA damage pathways

SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins

Evolutionary journey of the retroviral restriction gene Fv1

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells

Expression levels of Fv1: effects on retroviral restriction specificities

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

Evolution of the retroviral restriction gene Fv1: inhibition of non-MLV retroviruses

Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αs

A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid

TRIM proteins and the innate immune response to viruses

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

Unique spectrum of activity of prosimian TRIM5α against exogenous and endogenous retroviruses

Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein

Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors

The Francis Crick Institute is a unique partnership between