Miguel Munoz-Ruiz

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells

Preprint

Authors (13)

Pedro H Papotto
Elena Hernández-Garcia
Ángela Zarco-Cuadrillero
Ana Redondo-Urzainqui
James E Parkinson
Rúben GR Pinheiro
[...]
Bruno Silva-Santos
Judith E Allen
Adrian Hayday
Salvador Iborra
Miguel Munoz-Ruiz

bioRxiv

Published 18 December 2025

Crick labs

Adrian Hayday

Full details

T cell receptor γδ is a critical, real-time determinant of unique tissue surveillance mechanisms

Preprint

Authors (11)

Nicolas Veland
Bethania Garcia-Cassani
Ángela Zarco-Cuadrillero
Anna Maria Mavrigiannaki
Duncan McKenzie
Jannik Franken
Ana V Marin
Anett Jandke
Rosa Andres-ejarque
Adrian Hayday
Miguel Munoz-Ruiz

Research Square

Published 24 June 2025

Crick labs/ facilities

Full details

IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis

Authors (15)

Miguel Munoz-Ruiz
Miriam Llorian Sopena
Rocco D'Antuono
Anna Pavlova
Anna Maria Mavrigiannaki
Duncan McKenzie
[...]
Daniel Davies
Mariam Jamal-Hanjani
Anett Jandke
Dmitry S Ushakov
Adrian Hayday

Journal of Allergy and Clinical Immunology

Published 1 December 2023

Crick labs/ facilities

Full details

Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature

Authors (16)

Ambra Natalini
Sonia Simonetti
Gabriele Favaretto
Lorenzo Lucantonio
Giovanna Peruzzi
Miguel Munoz-Ruiz
[...]
Antonella Folgori
Alfredo Nicosia
Angela Santoni
Adrian Hayday
Francesca Di Rosa

Frontiers in Immunology

Published 14 February 2023

Crick labs/ facilities

Full details

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

Authors (41)

Magdalene Joseph
Yin Wu
Richard Dannebaum
Florian Rubelt
Iva Zlatareva
Anna Lorenc
[...]
Katie J Doores
Pierre Vantourout
Khai Luong
Jan Berka
Adrian Hayday

Proceedings of the National Academy of Sciences of the United States of America

Published 23 August 2022

Crick labs

Adrian Hayday

Full details

Normality sensing licenses local T cells for innate-like tissue surveillance

Authors (7)

Duncan McKenzie
Rosie Hart
Nourdine Bah
Dmitry S Ushakov
Miguel Munoz-Ruiz
Regina Feederle
Adrian Hayday

Nature Immunology

Published 1 March 2022

Crick labs/ facilities

Full details

GEO entry GSE164023: Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

Authors (1)

Miguel Munoz-Ruiz

Gene Expression Omnibus (GEO)

Published 1 February 2022

Crick labs/ facilities

Full details

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Authors (193)

Andrea Cossarizza
Hyun-Dong Chang
Andreas Radbruch
Sergio Abrignani
Richard Addo
Mübeccel Akdis
[...]
James Wing
Oliver Wirz
Jens Wittner
Jennie HM Yang
Juhao Yang

European Journal of Immunology

Published 1 December 2021

Crick labs/ facilities

Full details

OMIP-079: Cell cycle of CD4+ and CD8+ naïve/memory T cell subsets, and of Treg cells from mouse spleen

Authors (9)

Ambra Natalini
Sonia Simonetti
Gabriele Favaretto
Giovanna Peruzzi
Fabrizio Antonangeli
Angela Santoni
Miguel Munoz-Ruiz
Adrian Hayday
Francesca Di Rosa

Cytometry Part A

Published 1 December 2021

Crick labs/ facilities

Full details

Humoral and cellular immunity to delayed second dose of SARS-CoV-2 BNT162b2 mRNA vaccination in patients with cancer

Authors (28)

Duncan McKenzie
Miguel Munoz-Ruiz
Leticia Monin Aldama
Thanussuyah Alaguthurai
Thomas Lechmere
Sultan Abdul-Jawad
[...]
Bernard V North
Timothy Tree
Katie J Doores
Adrian Hayday
Sheeba Irshad

Cancer Cell

Published 8 November 2021

Crick labs

Adrian Hayday

Full details

Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study

Authors (44)

Leticia Monin Aldama
Adam G Laing
Miguel Munoz-Ruiz
Duncan McKenzie
Irene Del Molino Del Barrio
Thanussuyah Alaguthurai
[...]
Sophie Papa
Timothy Tree
Katie J Doores
Adrian Hayday
Sheeba Irshad

The Lancet Oncology

Published 1 June 2021

Crick labs

Adrian Hayday

Full details

Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients

Authors (51)

Sultan Abdul-Jawad
Luca Baù
Thanussuyah Alaguthurai
Irene Del Molino Del Barrio
Adam G Laing
Thomas S Hayday
[...]
Anne Rigg
Sophie Papa
Adrian Hayday
Piers EM Patten
Sheeba Irshad

Cancer Cell

Published 8 February 2021

Crick labs

Adrian Hayday

Full details

Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds

Authors (22)

Sara Campinoti
Asllan Gjinovci
Roberta Ragazzini
Luca Zanieri
Linda Ariza-Mcnaughton
Marco Catucci
[...]
Sarah A Teichmann
Neil J Sebire
Adrian Hayday
Dominique Bonnet
Paola Bonfanti

Nature Communications

Published 11 December 2020

Crick labs/ facilities

Full details

A dynamic COVID-19 immune signature includes associations with poor prognosis

Authors (50)

Adam G Laing
Anna Lorenc
Irene Del Molino Del Barrio
Abhishek Das
Matthew Fish
Leticia Monin Aldama
[...]
Katie J Doores
Francesca Di Rosa
Jonathan Edgeworth
Manu Shankar-Hari
Adrian Hayday

Nature Medicine

Published 1 October 2020

Crick labs/ facilities

Full details

γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis

Authors (18)

Leticia Monin Aldama
DS Ushakov
H Arnesen
N Bah
A Jandke
Miguel Munoz-Ruiz
[...]
M Curtis
H Carlsen
U Steinhoff
P Boysen
Adrian Hayday

Mucosal Immunology

Published 1 November 2020

Crick labs/ facilities

Full details

Tracking immunodynamics by identification of S-G2/M-phase T cells in human peripheral blood

Authors (9)

Miguel Munoz-Ruiz
Irma Pujol-Autonell
Hefin Rhys
Heather M Long
Maria Greco
Mark Peakman
Tim Tree
Adrian Hayday
Francesca Di Rosa

Journal of Autoimmunity

Published 1 August 2020

Crick labs/ facilities

Full details

Research partnerships

Technical training

We Go Way Back

About us

The Crick magazine

Miguel Munoz-Ruiz

Affiliated Researcher

Hayday lab

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells

T cell receptor γδ is a critical, real-time determinant of unique tissue surveillance mechanisms

IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis

Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

Normality sensing licenses local T cells for innate-like tissue surveillance

GEO entry GSE164023: Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

OMIP-079: Cell cycle of CD4+ and CD8+ naïve/memory T cell subsets, and of Treg cells from mouse spleen

Humoral and cellular immunity to delayed second dose of SARS-CoV-2 BNT162b2 mRNA vaccination in patients with cancer

Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study

Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients

Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds

A dynamic COVID-19 immune signature includes associations with poor prognosis

γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis

Tracking immunodynamics by identification of S-G2/M-phase T cells in human peripheral blood

The Francis Crick Institute is a unique partnership between