Miriam Molina Arcas

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

Authors (17)

Sissy E Wamaitha
Katarzyna J Grybel
Gregorio Alanis-Lobato
Claudia Gerri
Sugako Ogushi
Afshan McCarthy
[...]
Phil Snell
Leila Christie
Julian Downward
James Turner
Kathy Niakan

Nature Communications

Published 7 February 2020

Crick labs/ facilities

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Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

Authors (12)

Miriam Molina Arcas
Christopher Moore
Sareena Rana
Febe Van Maldegem
Edurne Mugarza
Pablo Romero-Clavijo
[...]
Stuart Horswell
Lian-Sheng Li
Matthew R Janes
David Hancock
Julian Downward

Science Translational Medicine

Published 18 September 2019

Crick labs/ facilities

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RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Authors (17)

Daniël A Lionarons
David Hancock
Sareena Rana
Philip East
Christopher Moore
Miguel Murillo
[...]
Ian Rosewell
Ralph Fritsch
Richard Neubig
Miriam Molina Arcas
Julian Downward

Cancer Cell

Published 8 July 2019

Crick labs/ facilities

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SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

Authors (13)

Greg G Jones
Isabel Boned del Río
Sibel Sari
Aysen Sekerim
Lucy C Young
Nicole Hartig
[...]
Rob E Hynds
Winnie Lei
Miriam Molina Arcas
Julian Downward
Pablo Rodriguez-Viciana

Nature Communications

Published 10 June 2019

Crick labs

Julian Downward

Full details

Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA

Authors (14)

Matthew A Coelho
Sophie De Carne Trecesson
Sareena Rana
Davide Zecchin
Christopher Moore
Miriam Molina Arcas
[...]
Karin Barnouin
Bram Snijders
Wi S Lai
Perry J Blackshear
Julian Downward

Immunity

Published 19 December 2017

Crick labs/ facilities

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RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Authors (7)

Esther Castellano
Miriam Molina Arcas
Agata Adelajda Krygowska
Philip East
Patricia Warne
Alastair Nicol
Julian Downward

Nature Communications

Published 13 April 2016

Crick labs/ facilities

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Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer

Authors (5)

Miriam Molina Arcas
David Hancock
Clare Sheridan
Madhu S Kumar
Julian Downward

Cancer Discovery

Published 1 May 2013

Crick labs

Julian Downward

Full details

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

Authors (11)

Michael Steckel
Miriam Molina Arcas
Britta Weigelt
Michaela Marani
Patricia H Warne
Hanna Kuznetsov
Gavin Kelly
Becky Saunders
Michael Howell
Julian Downward
David Hancock

Cell Research

Published 1 August 2012

Crick labs/ facilities

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The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

Authors (13)

Madhu S Kumar
David Hancock
Miriam Molina Arcas
Michael Steckel
Phillip East
Markus Diefenbacher
[...]
Nik Matthews
Emma Nye
Gordon Stamp
Axel Behrens
Julian Downward

Cell

Published 27 April 2012

Crick labs/ facilities

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How to fool a wonder drug: truncate and dimerize

Authors (2)

Cancer Cell

Published 17 January 2012

Crick labs

Julian Downward

Full details

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Miriam Molina Arcas

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

How to fool a wonder drug: truncate and dimerize

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