Nicola Cook

Datasets associated with: Integrase anchors viral RNA to the HIV-1 capsid interior

Authors (13)

Matthew Singer
Florian Chenavier
Nicola Cook
Emma Punch
Jamie Smith
Zhiyu Zhou
[...]
Andrea Nans
Mark Skehel
Ian Taylor
Giulia Zanetti
Peter Cherepanov

Figshare

Published 6 March 2026

Crick labs/ facilities

Full details

Integrase anchors viral RNA to the HIV-1 capsid interior

Authors (19)

Matthew Singer
Zhen Li
Juan S Rey
Joshua Hope
Florian Chenavier
Nicola Cook
[...]
Giulia Zanetti
Peijun Zhang
Juan R Perilla
Alan N Engelman
Peter Cherepanov

Nature

Published 23 April 2026

Crick labs/ facilities

Full details

Zenodo deposit: Molecular dynamics scripts for "Integrase anchors viral RNA to the HIV-1 capsid interior"

Authors (11)

Zenodo

Published 12 July 2025

Crick labs/ facilities

Full details

Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes

Authors (26)

Ren Ren
Shenglin Cai
Xiaona Fang
Xiaoyi Wang
Zheng Zhang
Micol Damiani
[...]
Zhaofeng Luo
Weihong Tan
Yuri Korchev
Aleksandar P Ivanov
Joshua B Edel

Nature Communications

Published 14 November 2023

Crick labs

Peter Cherepanov

Full details

SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study

Authors (29)

Eleanor Parker
Jordan Thomas
Kelly J Roper
Samreen Ijaz
Tansy Edwards
Federica Marchesin
[...]
Malcolm G Semple
William A Paxton
Richard S Tedder
Georgios Pollakis
ISARIC4C Investigators

Frontiers in Immunology

Published 15 March 2023

Crick labs

Peter Cherepanov

Full details

The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function

Authors (15)

Matthew Singer
Tung Dinh
Lev Levintov
Arun S Annamalai
Juan S Rey
Lorenzo Briganti
[...]
Alan N Engelman
Baek Kim
Juan R Perilla
Mamuka Kvaratskhelia
Peter Cherepanov

mBio

Published 1 February 2023

Crick labs/ facilities

Full details

PDB entry 8A1P: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D

Authors (4)

Matthew Singer
Val Pye
Nicola Cook
Peter Cherepanov

Protein Data Bank (RCSB PDB)

Published 1 February 2023

Crick labs/ facilities

Full details

PDB entry 8A1Q: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor STP0404 (Pirmitegravir)

Authors (4)

Matthew Singer
Val Pye
Nicola Cook
Peter Cherepanov

Protein Data Bank (RCSB PDB)

Published 1 February 2023

Crick labs/ facilities

Full details

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

Authors (20)

Samreen Ijaz
Steve Dicks
Keerthana Jegatheesan
Eleanor Parker
Ksenia Katsanovskaja
Elen Vink
[...]
Peter JM Openshaw
J Kenneth Baillie
Malcolm G Semple
Richard S Tedder
for ISARIC4C Investigators

Journal of Infection

Published 1 August 2022

Crick labs

Peter Cherepanov

Full details

Multivalent interactions essential for lentiviral integrase function

Authors (20)

Allison Ballandras-Colas
Vidya Chivukula
Dominika Gruszka
Zelin Shan
Parmit K Singh
Val Pye
[...]
Ian Taylor
Dmitry Lyumkis
Hasan Yardimci
Alan N Engelman
Peter Cherepanov

Nature Communications

Published 3 May 2022

Crick labs/ facilities

Full details

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Authors (40)

Annachiara Rosa
Val Pye
Carl Graham
Luke Muir
Jeffrey Seow
Kevin Ng
[...]
Richard S Tedder
George Kassiotis
Laura E Mccoy
Katie J Doores
Peter Cherepanov

Science advances

Published 28 May 2021

Crick labs/ facilities

Full details

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Authors (10)

Nicola Cook
Wen Li
Dénes Berta
Magd Badaoui
Allison Ballandras-Colas
Andrea Nans
Abhay Kotecha
Edina Rosta
Alan N Engelman
Peter Cherepanov

Science

Published 14 February 2020

Crick labs/ facilities

Full details

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Authors (8)

Sooin Jang
Nicola Cook
Val Pye
Gregory J Bedwell
Amanda M Dudek
Parmit K Singh
Peter Cherepanov
Alan N Engelman

Nucleic Acids Research

Published 21 May 2019

Crick labs

Peter Cherepanov

Full details

A supramolecular assembly mediates lentiviral DNA integration

Authors (14)

Allison Ballandras-Colas
Daniel P Maskell
Erik Serrao
Julia Locke
Paolo Swuec
Stefán R Jónsson
[...]
Ian Taylor
Valgerdur Andrésdóttir
Alan N Engelman
Alessandro Costa
Peter Cherepanov

Science

Published 6 January 2017

Crick labs/ facilities

Full details

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

Authors (8)

Allison Ballandras-Colas
Monica Brown
Nicola Cook
Tamaria G Dewdney
Borries Demeler
Peter Cherepanov
Dmitry Lyumkis
Alan N Engelman

Nature

Published 18 February 2016

Crick labs

Peter Cherepanov

Full details

Structural basis for nuclear import of splicing factors by human Transportin 3

Authors (14)

Goedele N Maertens
Nicola Cook
Weifeng Wang
Stephen Hare
Saumya Shree Gupta
Ilker Öztop
[...]
Bram Snijders
Vineet N KewalRamani
Ariberto Fassati
Alan Engelman
Peter Cherepanov

Proceedings of the National Academy of Sciences of the United States of America

Published 18 February 2014

Crick labs/ facilities

Full details

Research partnerships

Technical training

We Go Way Back

About us

The Crick magazine

Nicola Cook

Senior Laboratory Research Scientist

Cherepanov lab

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

Datasets associated with: Integrase anchors viral RNA to the HIV-1 capsid interior

Integrase anchors viral RNA to the HIV-1 capsid interior

Zenodo deposit: Molecular dynamics scripts for "Integrase anchors viral RNA to the HIV-1 capsid interior"

Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes

SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study

The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function

PDB entry 8A1P: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D

PDB entry 8A1Q: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor STP0404 (Pirmitegravir)

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

Multivalent interactions essential for lentiviral integrase function

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

A supramolecular assembly mediates lentiviral DNA integration

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

Structural basis for nuclear import of splicing factors by human Transportin 3

The Francis Crick Institute is a unique partnership between