Technical training Our platforms and facilities have training available for researchers outside the Crick.
We Go Way Back 16 Jul - 2 Jul Unlock the secrets hidden in our DNA and discover the extraordinary story of humanity.
Breadcrumb Research A-Z researchers Oliver Willhoft Postdoctoral Fellow Costa lab Macromolecular Machines Laboratory Year published 2026 (1) 2024 (8) 2021 (1) 2018 (2) Facet Year published Research topics Biochemistry & Proteomics (3) Cell Biology (1) Cell Cycle & Chromosomes (3) Chemical Biology & High Throughput (1) Genetics & Genomics (1) Genome Integrity & Repair (2) Imaging (2) Model Organisms (1) Structural Biology & Biophysics (3) Facet Research topics Crick Pre-Crick Crick publications (10) Pre-Crick publications (2) Facet Crick Pre-Crick Publication type Dataset (7) Journal article (5) Primary research (4) Review (1) Facet Publication type Journal Current Opinion in Structural Biology (1) Nature (2) Nature Structural and Molecular Biology (9) Facet Journal Displaying 1 - 12 of 12Last updated : 18 August 2026 02:52 Structure of the pre-initiation complex explains CMGE biogenesis Authors (9) Thomas Puehringer Berta Canal Giacomo Palm Agata Butryn Emma C Couves Oliver Willhoft Jacob Lewis John Diffley Alessandro Costa Nature Published 30 July 2026 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Fermentation Full details EMDB dataset EMD-17458: S. cerevisiae ssDNA-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details EMDB entry EMD-17449: S. cerevisiae nexus-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details EMDB entry EMD-17459: S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation Authors (2) Oliver Willhoft Sarah Henrikus Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details EMDB entry EMD-17460: S. cerevisiae sCMGE with N-ter Mcm10 density Authors (2) Sarah Henrikus Oliver Willhoft Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details PDB entry 8P5E: S. cerevisiae nexus-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Protein Data Bank (RCSB PDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details PDB entry 8P62: S. cerevisiae ssDNA-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Protein Data Bank (RCSB PDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details PDB entry 8P63: S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Protein Data Bank (RCSB PDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details Unwinding of a eukaryotic origin of replication visualized by cryo-EM Authors (11) Sarah Henrikus Marta Gross Oliver Willhoft Thomas Puehringer Jacob Lewis Allison McClure Julia Greiwe Giacomo Palm Andrea Nans John Diffley Alessandro Costa Nature Structural and Molecular Biology Published 1 August 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details A structural framework for DNA replication and transcription through chromatin Authors (2) Oliver Willhoft Alessandro Costa Current Opinion in Structural Biology Published 1 December 2021 Crick labs Alessandro Costa Full details Structure and regulation of the human INO80-nucleosome complex Authors (8) Rafael Ayala Oliver Willhoft Ricardo J Aramayo Martin Wilkinson Elizabeth A McCormack Lorraine Ocloo Dale B Wigley Xiaodong Zhang Nature Published 19 April 2018 Crick labs Xiaodong Zhang Full details Cryo-EM structures of the human INO80 chromatin-remodeling complex Authors (6) Ricardo J Aramayo Oliver Willhoft Rafael Ayala Rohan Bythell-Douglas Dale B Wigley Xiaodong Zhang Nature Structural and Molecular Biology Published 1 January 2018 Crick labs Xiaodong Zhang Full details
Structure of the pre-initiation complex explains CMGE biogenesis Authors (9) Thomas Puehringer Berta Canal Giacomo Palm Agata Butryn Emma C Couves Oliver Willhoft Jacob Lewis John Diffley Alessandro Costa Nature Published 30 July 2026 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Fermentation Full details
EMDB dataset EMD-17458: S. cerevisiae ssDNA-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
EMDB entry EMD-17449: S. cerevisiae nexus-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
EMDB entry EMD-17459: S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation Authors (2) Oliver Willhoft Sarah Henrikus Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
EMDB entry EMD-17460: S. cerevisiae sCMGE with N-ter Mcm10 density Authors (2) Sarah Henrikus Oliver Willhoft Electron Microscopy Data Bank (EMDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
PDB entry 8P5E: S. cerevisiae nexus-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Protein Data Bank (RCSB PDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
PDB entry 8P62: S. cerevisiae ssDNA-sCMGE after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Protein Data Bank (RCSB PDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
PDB entry 8P63: S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation Authors (2) Sarah Henrikus Oliver Willhoft Protein Data Bank (RCSB PDB) Published 29 May 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
Unwinding of a eukaryotic origin of replication visualized by cryo-EM Authors (11) Sarah Henrikus Marta Gross Oliver Willhoft Thomas Puehringer Jacob Lewis Allison McClure Julia Greiwe Giacomo Palm Andrea Nans John Diffley Alessandro Costa Nature Structural and Molecular Biology Published 1 August 2024 Crick labs/ facilities John Diffley Alessandro Costa Structural Biology Full details
A structural framework for DNA replication and transcription through chromatin Authors (2) Oliver Willhoft Alessandro Costa Current Opinion in Structural Biology Published 1 December 2021 Crick labs Alessandro Costa Full details
Structure and regulation of the human INO80-nucleosome complex Authors (8) Rafael Ayala Oliver Willhoft Ricardo J Aramayo Martin Wilkinson Elizabeth A McCormack Lorraine Ocloo Dale B Wigley Xiaodong Zhang Nature Published 19 April 2018 Crick labs Xiaodong Zhang Full details
Cryo-EM structures of the human INO80 chromatin-remodeling complex Authors (6) Ricardo J Aramayo Oliver Willhoft Rafael Ayala Rohan Bythell-Douglas Dale B Wigley Xiaodong Zhang Nature Structural and Molecular Biology Published 1 January 2018 Crick labs Xiaodong Zhang Full details
