Phil East

Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

Preprint

Authors (24)

Sophie de Carne
Phil East
Claire E Pillsbury
Mariana Silva Dos Santos
Hongui Cha
Emma Colliver
[...]
Se-Hoon Lee
James MacRae
Philip Hobson
Charles Swanton
Julian Downward

bioRxiv

Published 26 November 2025

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Cell cycle regulation has shaped replication origins in budding yeast

Authors (10)

Chew Theng Lim
Thomas Miller
Kang Wei Tan
Saurabh Talele
Anne Early
Phil East
Humberto Sánchez
Nynke H Dekker
Alessandro Costa
John Diffley

Nature Structural & Molecular Biology

Published 1 September 2025

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Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma

Authors (37)

Dhruva Biswas
Yun-Hsin Liu
Javier Herrero
Yin Wu
David A Moore
Takahiro Karasaki
[...]
Allan Hackshaw
Mariam Jamal-Hanjani
Nnennaya Kanu
Nicolai Birkbak
Charles Swanton

Nature Cancer

Published 1 January 2025

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Data from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Authors (14)

Figshare

Published 15 July 2024

Crick labs/ facilities

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Supplementary Table 1 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Authors (14)

Figshare

Published 15 July 2024

Crick labs/ facilities

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Supplementary Table 2 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Authors (14)

Zenodo

Published 15 July 2024

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Supplementary Table 3 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Authors (14)

Figshare

Published 15 July 2024

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CRISPR-Cas9 screening identifies KRAS-induced COX2 as a driver of immunotherapy resistance in lung cancer

Authors (16)

Jesse Boumelha
Andrea De Castro
Nourdine Bah
Hongui Cha
Sophie de Carne
Sareena Rana
[...]
Phil East
Kevin Litchfield
Se-Hoon Lee
Miriam Molina Arcas
Julian Downward

Cancer Research

Published 15 July 2024

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GEO entry GSE241689: MRTF-SRF signalling in the T cell IL2 response

Authors (4)

Phil East
Diane Maurice De Coulon
Francesco Gualdrini
Jimena Perez-Lloret

Gene Expression Omnibus (GEO)

Published 23 October 2023

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GEO entry GSE224412: RNA sequencing of resident human colonic gd T cells bearing the Vg2/3/4 receptor stimulated with butyrophilin-like (BTNL) 3 and BTNL8

Authors (3)

Gene Expression Omnibus (GEO)

Published 3 October 2023

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Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

Authors (14)

Robin J Dart
Iva Zlatareva
Pierre Vantourout
Efstathios Theodoridis
Ariella Amar
Shichina Kannambath
[...]
Christopher A Lamb
Miles Parkes
Peter M Irving
Natalie J Prescott
Adrian Hayday

Science

Published 15 September 2023

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A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

PLOS Biology

Published 17 July 2023

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Antibodies used for immunofluoresence assays for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

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Data for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells - Raw data for c-Myc nuclear translocation assays

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

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Data for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells. S4 Data. Co-immunoprecipitation and mass spectrometry results

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

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Data from CRISPR screens in RH and PRU parasites for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

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Opera Phenix image acquisition parameters and Harmony analysis sequence used for automated ubiquitin recruitment analysis for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

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Primer sequences used in "A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells"

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

Crick labs/ facilities

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Raw data for Compound 2 egress inhibition assays for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

Crick labs/ facilities

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Raw data for Cytation plate reader IFNγ survival assays for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Authors (8)

Eloise Lockyer
Francesca Torelli
Simon Butterworth
Ok-Ryul Song
Steven Howell
Anne Weston
Phil East
Moritz Treeck

Figshare

Published 17 July 2023

Crick labs/ facilities

Full details

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Phil East

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Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

Cell cycle regulation has shaped replication origins in budding yeast

Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma

Data from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Supplementary Table 1 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Supplementary Table 2 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Supplementary Table 3 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

CRISPR-Cas9 screening identifies KRAS-induced COX2 as a driver of immunotherapy resistance in lung cancer

GEO entry GSE241689: MRTF-SRF signalling in the T cell IL2 response

GEO entry GSE224412: RNA sequencing of resident human colonic gd T cells bearing the Vg2/3/4 receptor stimulated with butyrophilin-like (BTNL) 3 and BTNL8

Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Antibodies used for immunofluoresence assays for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Data for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells - Raw data for c-Myc nuclear translocation assays

Data for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells. S4 Data. Co-immunoprecipitation and mass spectrometry results

Data from CRISPR screens in RH and PRU parasites for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Opera Phenix image acquisition parameters and Harmony analysis sequence used for automated ubiquitin recruitment analysis for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Primer sequences used in "A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells"

Raw data for Compound 2 egress inhibition assays for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

Raw data for Cytation plate reader IFNγ survival assays for: A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

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