Phil East

An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations

Authors (26)

Jesse Boumelha
Sophie de Carne
Emily K Law
Pablo Romero-Clavijo
Matthew A Coelho
Kevin Ng
[...]
George Kassiotis
Miriam Molina Arcas
Charles Swanton
Reuben Harris
Julian Downward

Cancer Research

Published 1 October 2022

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Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain

Authors (20)

Sophy Charlton
Selina Brace
Mateja Hajdinjak
Rebecca Kearney
Thomas Booth
Hazel Reade
[...]
Tom Higham
Chris Stringer
Pontus Skoglund
Ian Barnes
Rhiannon E Stevens

Nature Ecology and Evolution

Published 1 November 2022

Crick labs/ facilities

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Nodal signaling establishes a competency window for stochastic cell fate switching

Authors (4)

Developmental Cell

Published 5 December 2022

Crick labs/ facilities

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RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

Authors (11)

Phil East
Gavin Kelly
Dhruva Biswas
Michela Marani
David Hancock
Todd Creasy
Kris Sachsenmeier
Charles Swanton
TRACERx consortium
Julian Downward
Sophie de Carne

Nature Communications

Published 26 September 2022

Crick labs/ facilities

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Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

Authors (15)

Cancer Cell

Published 9 January 2023

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Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers

Authors (14)

Science advances

Published 22 July 2022

Crick labs/ facilities

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Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Authors (12)

Luca Guglielmi
Claire Heliot
Sunil Kumar
Yuriy Alexandrov
Ilaria Gori
Foteini Papaleonidopoulou
[...]
Phil East
Andrew Economou
Paul MW French
James McGinty
Caroline Hill

Nature Communications

Published 4 November 2021

Crick labs/ facilities

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Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

Authors (12)

Anett Jandke
Daisy Melandri
Leticia Monin Aldama
Dmitry S Ushakov
Adam G Laing
Pierre Vantourout
[...]
Takeshi Nitta
Tomoya Narita
Hiroshi Takayanagi
Regina Feederle
Adrian Hayday

Nature Communications

Published 28 July 2020

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GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells

Authors (13)

Alix Gunne-Braden
Adrienne Sullivan
Borzo Gharibi
Rahuman SM Sheriff
Alok Maity
Yi-Fang Wang
[...]
Michael Howell
Robert Goldstone
Roy Wollman
Phil East
Silvia Santos

Cell Stem Cell

Published 7 May 2020

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RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Authors (17)

Cancer Cell

Published 8 July 2019

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Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

Authors (9)

Davide Coda
Tessa Gaarenstroom
Phil East
Harshil Patel
Daniel Miller
Anna Lobley
Nik Matthews
Aengus Stewart
Caroline Hill

eLife

Published 13 February 2017

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ERK-induced activation of TCF family of SRF cofactors initiates a chromatin modification cascade associated with transcription

Authors (8)

Cyril Esnault
Francesco Gualdrini
Stuart Horswell
Gavin Kelly
Aengus Stewart
Phil East
Nik Matthews
Richard Treisman

Molecular Cell

Published 16 March 2017

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Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA

Authors (14)

Matthew A Coelho
Sophie de Carne
Sareena Rana
Davide Zecchin
Christopher Moore
Miriam Molina Arcas
[...]
Karin Barnouin
Bram Snijders
Wi S Lai
Perry J Blackshear
Julian Downward

Immunity

Published 19 December 2017

Crick labs/ facilities

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UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene

Authors (13)

Laura Williamson
Marco Saponaro
Stefan Boeing
Phil East
Richard Mitter
Theodoros Kantidakis
[...]
Jane Walker
Bradley Spencer-Dene
Michael Howell
Aengus Stewart
Jesper Svejstrup

Cell

Published 23 February 2017

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Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments

Authors (18)

Rafael Di Marco Barros
Natalie A Roberts
Robin J Dart
Pierre Vantourout
Anett Jandke
Oliver Nussbaumer
[...]
Deena Gibbons
Peter M Irving
Pablo Pereira
Ulrich Steinhoff
Adrian Hayday

Cell

Published 22 September 2016

Crick labs/ facilities

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RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Authors (7)

Esther Castellano
Miriam Molina Arcas
Agata Adelajda Krygowska
Phil East
Patricia Warne
Alastair Nicol
Julian Downward

Nature Communications

Published 13 April 2016

Crick labs/ facilities

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Retention of the native epigenome in purified mammalian chromatin

Authors (7)

Andreas H Ehrensberger
Don-Marc Franchini
Phil East
Roger George
Nik Matthews
Sarah L Maslen
Jesper Svejstrup

PLOS ONE

Published 6 August 2015

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Retraction: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

Authors (7)

Madhu S Kumar
Elena Armenteros-Monterroso
Phil East
Probir Chakravorty
Nik Matthews
Monte M Winslow
Julian Downward

Nature

Published 10 June 2015

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SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Authors (29)

N Kanu
Eva Gronroos
P Martinez
RA Burrell
X Yi Goh
J Bartkova
[...]
Aengus Stewart
Z Szallasi
J Larkin
J Bartek
Charles Swanton

Oncogene

Published 12 November 2015

Crick labs/ facilities

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SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

Authors (12)

CA Lewis
C Brault
B Peck
K Bensaad
B Griffiths
R Mitter
[...]
Phil East
B Dankworth
D Alibhai
AL Harris
A Schulze

Oncogene

Published 1 October 2015

Crick labs/ facilities

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Research case studies

2023 Summer Student Training Programme

Cut + Paste

Coronavirus (COVID-19) research

About us

Phil East

STP DEPUTY

Bioinformatics and Biostatistics

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Research topics

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Crick Pre-Crick

An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations

Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain

Nodal signaling establishes a competency window for stochastic cell fate switching

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

ERK-induced activation of TCF family of SRF cofactors initiates a chromatin modification cascade associated with transcription

Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA

UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene

Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Retention of the native epigenome in purified mammalian chromatin

Retraction: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

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