Philip Walker

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Authors (47)

Kevin Ng
Nikhil Faulkner
Georgina H Cornish
Annachiara Rosa
Ruth Harvey
Saira Hussain
[...]
Steve Gamblin
Laura E Mccoy
Peter Cherepanov
Eleni Nastouli
George Kassiotis

Science

Published 11 December 2020

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Scalable and robust SARS-CoV-2 testing in an academic center

Authors (81)

Jim Aitken
Karen Ambrose
Sam Barrell
Rupert Beale
Ganka Bineva-Todd
Dhruva Biswas
[...]
Sophia Ward
Wai Keong Wong
Joshua Wright
Mary Wu
The Crick COVID-19 Consortium

Uncoupling conformational states from activity in an allosteric enzyme

Authors (9)

João P Pisco
Cesira De Chiara
Kamila J Pacholarz
Acely Garza-Garcia
Roksana Ogrodowicz
Philip Walker
Perdita E Barran
Stephen J Smerdon
Luiz Pedro Carvalho

Nature Communications

Published 7 August 2017

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Structure and function analysis of an antibody recognizing all influenza A subtypes

Authors (29)

Nicole L Kallewaard
Davide Corti
Patrick J Collins
Ursula Neu
Josephine M McAuliffe
Ebony Benjamin
[...]
JoAnn A Suzich
Antonio Lanzavecchia
Qing Zhu
Steve Gamblin
John J Skehel

Cell

Published 28 July 2016

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Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Authors (12)

Neil Justin
Ying Zhang
Cataldo Tarricone
Stephen R Martin
Shuyang Chen
Elizabeth Underwood
[...]
Lesley F Haire
Philip Walker
Danny Reinberg
Jon Wilson
Steve Gamblin

Nature Communications

Published 28 April 2016

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Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody

Authors (18)

X Xiong
D Corti
J Liu
D Pinna
M Foglierini
Lesley Calder
[...]
NJ Temperton
K Subbarao
A Lanzavecchia
Steve Gamblin
JJ Skehel

Proceedings of the National Academy of Sciences of the United States of America

Published 28 July 2015

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Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx

Authors (7)

David Schwefel
Virginie C Boucherit
Evangelos Christodoulou
Philip Walker
Jonathan Stoye
Kate Bishop
Ian Taylor

Cell Host & Microbe

Published 8 April 2015

Crick labs/ facilities

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Structural basis of lentiviral subversion of a cellular protein degradation pathway

Authors (8)

David Schwefel
Harriet CT Groom
Virginie C Boucherit
Evangelos Christodoulou
Philip Walker
Jonathan Stoye
Kate Bishop
Ian Taylor

Nature

Published 15 December 2014

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Recent evolution of equine influenza and the origin of canine influenza

Authors (9)

Patrick J Collins
Sebastien G Vachieri
Lesley F Haire
Roksana Ogrodowicz
Stephen R Martin
Philip Walker
Xiaoli Xiong
Steve Gamblin
John J Skehel

Proceedings of the National Academy of Sciences of the United States of America

Published 14 July 2014

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Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

Authors (11)

David C Goldstone
Philip Walker
Lesley Calder
Peter J Coombs
Joshua Kirkpatrick
Neil J Ball
Laura Hilditch
Melvyn W Yap
Peter Rosenthal
Jonathan Stoye
Ian Taylor

Proceedings of the National Academy of Sciences of the United States of America

Published 1 July 2014

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Receptor binding by H10 influenza viruses

Authors (10)

Sebastien G Vachieri
Xiaoli Xiong
Patrick J Collins
Philip Walker
Stephen R Martin
Lesley F Haire
Ying Zhang
John Mccauley
Steve Gamblin
John J Skehel

Nature

Published 28 May 2014

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Enhanced human receptor binding by H5 haemagglutinins

Authors (12)

Xiaoli Xiong
Haixia Xiao
Stephen R Martin
Peter J Coombs
Junfeng Liu
Patrick J Collins
[...]
Philip Walker
Yi Pu Lin
John Mccauley
Steve Gamblin
John J Skehel

Virology

Published 1 May 2014

Crick labs/ facilities

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The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

Authors (9)

Chrislaine Withers-Martinez
Malcolm Strath
Fiona Hackett
Lesley F Haire
Steven A Howell
Philip Walker
Evangelos Christodoulou
Guy G Dodson
Michael Blackman

Nature Communications

Published 1 January 2014

Crick labs/ facilities

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Structural basis of AMPK regulation by small molecule activators

Authors (14)

Bing Xiao
Matthew J Sanders
David Carmena
Nicola J Bright
Lesley F Haire
Elizabeth Underwood
[...]
Stefan Hallen
Fabrizio Giordanetto
Stephen R Martin
David Carling
Steve Gamblin

Nature Communications

Published 19 December 2013

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Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus

Authors (8)

X Xiong
A Tuzikov
PJ Coombs
S Martin
Philip Walker
Steve Gamblin
N Bovin
JJ Skehel

Virus Research

Published 10 September 2013

Crick labs/ facilities

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Receptor binding by a ferret-transmissible H5 avian influenza virus

Authors (12)

X Xiong
PJ Coombs
SR Martin
J Liu
H Xiao
John Mccauley
[...]
Philip Walker
PJ Collins
Y Kawaoka
JJ Skehel
Steve Gamblin

Nature

Published 1 January 2013

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Receptor binding by an H7N9 influenza virus from humans

Authors (11)

Xiaoli Xiong
Stephen R Martin
Lesley F Haire
Stephen A Wharton
Rodney S Daniels
Michael S Bennett
John Mccauley
Patrick J Collins
Philip Walker
John J Skehel
Steve Gamblin

Nature

Published 1 January 2013

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Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin

Authors (14)

Yi Pu Lin
Xiaoli Xiong
Stephen A Wharton
Stephen R Martin
Peter J Coombs
Sebastien G Vachieri
[...]
John J Skehel
Steve Gamblin
Alan J Hay
Rodney S Daniels
John Mccauley

Proceedings of the National Academy of Sciences of the United States of America

Published 1 January 2012

Crick labs/ facilities

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H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis

Authors (14)

Erhard van der Vries
Patrick J Collins
Sebastien G Vachieri
Xiaoli Xiong
Junfeng Liu
Philip Walker
[...]
Albert DME Osterhaus
Steve R Martin
Charles AB Boucher
John J Skehel
Steve Gamblin

PLOS Pathogens

Published 1 January 2012

Crick labs/ facilities

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Research case studies

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Pathway to Discovery

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About us

Philip Walker

STP LEAD

Structural Biology

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Crick Pre-Crick

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Scalable and robust SARS-CoV-2 testing in an academic center

Uncoupling conformational states from activity in an allosteric enzyme

Structure and function analysis of an antibody recognizing all influenza A subtypes

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody

Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx

Structural basis of lentiviral subversion of a cellular protein degradation pathway

Recent evolution of equine influenza and the origin of canine influenza

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

Receptor binding by H10 influenza viruses

Enhanced human receptor binding by H5 haemagglutinins

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

Structural basis of AMPK regulation by small molecule activators

Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus

Receptor binding by a ferret-transmissible H5 avian influenza virus

Receptor binding by an H7N9 influenza virus from humans

Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin

H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis

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