Rachel Lai

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

Authors (8)

Journal of Cell Science

Published 1 March 2021

Crick labs/ facilities

Full details

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

Authors (9)

JCI insight

Published 21 May 2020

Crick labs/ facilities

Full details

Standardized approaches for clinical sampling and endpoint ascertainment in tuberculous meningitis studies

Authors (12)

Ursula K Rohlwink
Felicia C Chow
Sean Wasserman
Sofiati Dian
Rachel Lai
Lidya Chaidir
[...]
Robert J Wilkinson
David R Boulware
Fiona V Cresswell
Arjan van Laarhoven
Tuberculous Meningitis International Research Consortium

Wellcome Open Research

Published 16 December 2019

Crick labs

Robert J Wilkinson

Full details

Mechanism, spectrum, consequences and management of hyponatremia in tuberculous meningitis

Authors (60)

Usha K Misra
Jayantee Kalita
Tuberculous Meningitis International Research Consortium
Rob E Aarnoutse
Suzanne TB Anderson
Nathan C Bahr
[...]
Guy E Thwaites
Ronald van Toorn
Elizabeth W Tucker
Sean A Wasserman
Robert J Wilkinson

Wellcome Open Research

Published 28 November 2019

Crick labs

Robert J Wilkinson

Full details

The current global situation for tuberculous meningitis: Epidemiology, diagnostics, treatment and outcomes

Authors (60)

JA Seddon
L Tugume
R Solomons
K Prasad
NC Bahr
RE Aarnoutse
[...]
R van Toorn
EW Tucker
SA Wasserman
Robert J Wilkinson
Tuberculous Meningitis International Research Consortium

Wellcome Open Research

Published 5 November 2019

Crick labs

Robert J Wilkinson

Full details

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Authors (13)

Ursula K Rohlwink
Anthony Figaji
Katalin Wilkinson
Stuart Horswell
Abdul K Sesay
Armin Deffur
[...]
Ronald Van Toorn
Brian Eley
Michael Levin
Robert J Wilkinson
Rachel Lai

Nature Communications

Published 21 August 2019

Crick labs/ facilities

Full details

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis

Authors (10)

Hanif Esmail
Rachel Lai
Maia Lesosky
Katalin Wilkinson
Christine Graham
Stuart Horswell
Anna K Coussens
Clifton E Barry
Anne O'Garra
Robert J Wilkinson

Proceedings of the National Academy of Sciences of the United States of America

Published 30 January 2018

Crick labs/ facilities

Full details

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study

Authors (7)

J Shenje
Rachel Lai
IL Ross
BM Mayosi
Robert J Wilkinson
M Ntsekhe
Katalin Wilkinson

International Journal of Cardiology Heart & Vasculature

Published 1 March 2018

Crick labs

Robert J Wilkinson

Full details

A Rab20-dependent membrane trafficking pathway controls M. tuberculosis replication by regulating phagosome spaciousness and integrity

Authors (9)

Laura Schnettger
Angela Rodgers
Urska Repnik
Rachel Lai
Gang Pei
Martijn Verdoes
Robert J Wilkinson
Douglas B Young
Maximiliano Gutierrez

Cell Host & Microbe

Published 10 May 2017

Crick labs/ facilities

Full details

Inflammasome activation underlies central nervous system deterioration in HIV-associated tuberculosis

Authors (6)

Journal of Infectious Diseases

Published 1 March 2017

Crick labs

Full details

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ-glucose positron emission and computed tomography

Authors (16)

Hanif Esmail
Rachel Lai
Maia Lesosky
Katalin Wilkinson
Christine Graham
Anna K Coussens
[...]
JoAnne L Flynn
Douglas B Young
Clifton E Barry III
Anne O'Garra
Robert J Wilkinson

Nature Medicine

Published 1 October 2016

Crick labs

Full details

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

Authors (17)

Rachel Lai
Graeme Meintjes
Katalin Wilkinson
Christine Graham
Suzaan Marais
Helen Van der Plas
[...]
Gary Maartens
Jacques Banchereau
Damien Chaussabel
Anne O'Garra
Robert J Wilkinson

Nature Communications

Published 24 September 2015

Crick labs

Full details

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

Authors (19)

Egidio Torrado
Jeffrey J Fountain
Mingfeng Liao
Michael Tighe
William W Reiley
Rachel Lai
[...]
K Kai McKinstry
Tara M Strutt
Robert J Wilkinson
Susan L Swain
Andrea M Cooper

Journal of Experimental Medicine

Published 24 August 2015

Crick labs

Robert J Wilkinson

Full details

A-Z of research labs

PhD student recruitment

Engaging our community

Family Zone

Coronavirus (COVID-19) research

Coronavirus (COVID-19) response

Rachel Lai

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

Standardized approaches for clinical sampling and endpoint ascertainment in tuberculous meningitis studies

Mechanism, spectrum, consequences and management of hyponatremia in tuberculous meningitis

The current global situation for tuberculous meningitis: Epidemiology, diagnostics, treatment and outcomes

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study

A Rab20-dependent membrane trafficking pathway controls M. tuberculosis replication by regulating phagosome spaciousness and integrity

Inflammasome activation underlies central nervous system deterioration in HIV-associated tuberculosis

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ-glucose positron emission and computed tomography

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

The Francis Crick Institute is a unique partnership between