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Rakhee ChauhanLab: Signalling and Structural Biology LaboratoryJob Title: Postdoc Breadcrumb Home Research Researchers Rakhee Chauhan Year published2020 (2)2017 (1)2016 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (4)Chemical Biology & High Throughput (1)Human Biology & Physiology (1)Signalling & Oncogenes (4)Stem Cells (1)Structural Biology & Biophysics (4)Tumour Biology (1) Facet Research topicsCrick Pre-CrickCrick publications (4) Facet Crick Pre-CrickPublication typeJournal article (4)Primary research (4) Facet Publication typeJournalBlood (1)Cell Reports (1)Journal of Medicinal Chemistry (1)Science Translational Medicine (1) Facet Journal Displaying 1 - 4 of 4Last updated : 28 February 2021 03:37 Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency Authors (7)William GreyRakhee ChauhanMarion PiganeauHector Huerga Encabo M Garcia-AlbornozNeil McDonaldDominique Bonnet Blood Published 26 November 2020 Crick labs/ facilitiesNeil McDonaldDominique BonnetFlow CytometryBiological Research FacilityFull details Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology Authors (13) Marialuisa Moccia Brendan Frett Lingtain Zhang Naga Rajiv LakkanigaDavid BriggsRakhee Chauhan[...] Wei Yan Massimo SantoroNeil McDonald Hong-yu Li Francesca Carlomagno Journal of Medicinal Chemistry Published 14 May 2020 Crick labsNeil McDonaldFull details Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors Authors (35) Dennis Plenker Maximilian Riedel Johannes Brägelmann Marcel A DammertRakhee Chauhan Phillip P Knowles[...]Neil McDonald Stefan M Kast Oliver Gautschi Roman K Thomas Martin L Sos Science Translational Medicine Published 14 June 2017 Crick labsNeil McDonaldFull details RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements Authors (10) Iván Plaza-Menacho Karin Barnouin Rachael BarryAnnabel Borg Mariam OrmeRakhee Chauhan Stephane Mouilleron Rubén J Martínez-Torres Pascal MeierNeil McDonald Cell Reports Published 20 December 2016 Crick labs/ facilitiesNeil McDonaldStructural BiologyProteomicsPeptide ChemistryFull details
Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency Authors (7)William GreyRakhee ChauhanMarion PiganeauHector Huerga Encabo M Garcia-AlbornozNeil McDonaldDominique Bonnet Blood Published 26 November 2020 Crick labs/ facilitiesNeil McDonaldDominique BonnetFlow CytometryBiological Research FacilityFull details
Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology Authors (13) Marialuisa Moccia Brendan Frett Lingtain Zhang Naga Rajiv LakkanigaDavid BriggsRakhee Chauhan[...] Wei Yan Massimo SantoroNeil McDonald Hong-yu Li Francesca Carlomagno Journal of Medicinal Chemistry Published 14 May 2020 Crick labsNeil McDonaldFull details
Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors Authors (35) Dennis Plenker Maximilian Riedel Johannes Brägelmann Marcel A DammertRakhee Chauhan Phillip P Knowles[...]Neil McDonald Stefan M Kast Oliver Gautschi Roman K Thomas Martin L Sos Science Translational Medicine Published 14 June 2017 Crick labsNeil McDonaldFull details
RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements Authors (10) Iván Plaza-Menacho Karin Barnouin Rachael BarryAnnabel Borg Mariam OrmeRakhee Chauhan Stephane Mouilleron Rubén J Martínez-Torres Pascal MeierNeil McDonald Cell Reports Published 20 December 2016 Crick labs/ facilitiesNeil McDonaldStructural BiologyProteomicsPeptide ChemistryFull details
