Robert Goldstone

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Authors (16)

Simeon Mihaylov
Lydia M Castelli
Ya-Hui Lin
Aytac Gül
Nikita Soni
Christopher Hastings
[...]
Oliver Bandmann
Tatyana A Shelkovnikova
Heather Mortiboys
Sila Ultanir
Guillaume M Hautbergue

Nature Communications

Published 7 September 2023

Crick labs/ facilities

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Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London

Authors (54)

Chris Bailey
Theo Sanderson
Hermaleigh Townsley
Jacki Goldman
James RM Black
George Young
[...]
Jerome Nicod
Sonia Gandhi
David LV Bauer
Emma C Wall
Charles Swanton

The Lancet

Published 1 July 2023

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Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils

Authors (22)

Hector Huerga Encabo
Iker Valle Aramburu
Manuel Garcia Albornoz
Marion Piganeau
Henry Wood
Anna Song
[...]
Daniel H Wiseman
Kiran Batta
Rajeev Gupta
Venizelos Papayannopoulos
Dominique Bonnet

Cell Stem Cell

Published 1 June 2023

Crick labs/ facilities

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Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation

Authors (12)

Genes and Development

Published 1 March 2023

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Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

Authors (15)

Cancer Cell

Published 9 January 2023

Crick labs/ facilities

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Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening

Authors (16)

Marianna Ioannou
Dennis Hoving
Iker Valle Aramburu
Mia Temkin
Nathalia M De Vasconcelos
Theodora Dorita Tsourouktsoglou
[...]
Markus Ralser
Sascha David
Klaus Stahl
Christian Bode
Venizelos Papayannopoulos

Nature Communications

Published 9 August 2022

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Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

Authors (12)

Valerie Borel
Stefan Boeing
Niek Van Wietmarschen
Sriram Sridharan
Bethany Rebekah Hill
Luigi Ombrato
[...]
Deb Jackson
Robert Goldstone
Simon Boulton
Andre Nussenzweig
Roberto Bellelli

Cell Reports

Published 31 May 2022

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Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study

Authors (89)

Nature Cancer

Published 1 December 2021

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Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Authors (9)

Michael Lattke
Robert Goldstone
James Ellis
Stefan Boeing
Jerónimo Jurado-Arjona
Nicolás Marichal
James Macrae
Benedikt Berninger
Francois Guillemot

Nature Communications

Published 15 July 2021

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Immunogenomics of colorectal cancer response to checkpoint blockade: analysis of the KEYNOTE 177 trial and validation cohorts

Authors (29)

Michele Bortolomeazzi
Reda Keddar
Lucia Montorsi
Amelia Acha
Lorena Benedetti
Damjan Temelkovski
[...]
Peter Parker
Manuel Rodriguez-Justo
Kai-Keen Shiu
Jo Spencer
Francesca Ciccarelli

Gastroenterology

Published 1 October 2021

Crick labs/ facilities

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Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination

Authors (25)

Emma C Wall
Mary Wu
Ruth Harvey
Gavin Kelly
Scott Warchal
Chelsea Sawyer
[...]
Vincenzo Libri
Bryan Williams
Charles Swanton
Sonia Gandhi
David LV Bauer

The Lancet

Published 19 June 2021

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SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay

Authors (40)

Wellcome Open Research

Published 21 May 2021

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RTEL1 regulates G4/R-loops to avert replication-transcription collisions

Authors (11)

Cell Reports

Published 22 December 2020

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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Authors (27)

Graeme Hewitt
Valerie Borel
Sandra Segura-Bayona
Tohru Takaki
Phil Ruis
Roberto Bellelli
[...]
Ivan Ahel
Dragana Ahel
J Ross Chapman
Sebastian Deindl
Simon Boulton

Molecular Cell

Published 18 February 2021

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells

Authors (13)

Alix Gunne-Braden
Adrienne Sullivan
Borzo Gharibi
Rahuman SM Sheriff
Alok Maity
Yi-Fang Wang
[...]
Michael Howell
Robert Goldstone
Roy Wollman
Phil East
Silvia Santos

Cell Stem Cell

Published 7 May 2020

Crick labs/ facilities

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Substantial extracellular metabolic differences found between phylogenetically closely related probiotic and pathogenic strains of Escherichia coli

Authors (5)

Justin JJ van der Hooft
Robert Goldstone
Susan Harris
Karl EV Burgess
David GE Smith

Frontiers in Microbiology

Published 19 February 2019

Crick labs/ facilities

Advanced Sequencing

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From local to global: preparing for the next pandemic

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The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London

Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils

Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation

Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening

Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study

Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Immunogenomics of colorectal cancer response to checkpoint blockade: analysis of the KEYNOTE 177 trial and validation cohorts

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay

RTEL1 regulates G4/R-loops to avert replication-transcription collisions

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells

Substantial extracellular metabolic differences found between phylogenetically closely related probiotic and pathogenic strains of Escherichia coli

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