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Sarah Caswell

Lab: Macromolecular Structure Laboratory
Job Title: PhD Student

Displaying 1 - 3 of 3

Last updated : 23 January 2021 02:21

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

Authors (7)

Liz Morris
Sarah Caswell
Simone Kunzelmann
Laurence H Arnold
Andrew G Purkiss
Geoff Kelly
Ian Taylor

Nature Communications

Published 23 June 2020

Crick labs/ facilities

DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages

Authors (5)

Petra Mlcochova
Sarah Caswell
Ian Taylor
Greg J Towers
Ravindra K Gupta

Published 30 October 2017

Crick labs

Ian Taylor

Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction

Authors (15)

Laurence H Arnold
Harriet CT Groom
Simone Kunzelmann
David Schwefel
Sarah Caswell
Paula Ordonez
[...]
Steven A Howell
Jonathan Stoye
Michelle Webb
Ian Taylor
Kate Bishop

Published 2 October 2015

Crick labs/ facilities