Sharon Tooze
Principal Group Leader
Sharon A. Tooze has a long-standing interest in molecular cell biology, starting with her PhD work at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.
At EMBL she studied transport of a viral glycoprotein from a SARS virus and showed that O-linked glycosylation starts in the ER-Golgi intermediate compartment (Tooze et al., JCB 1988). Afterwards she became interested in organelle biogenesis and in how immature secretory granules form from the trans-Golgi network in neuroendocrine cells (Tooze et al., Cell, 1990, Nature 1990).
Tooze maintained her interest in the biogenesis of secretory granules when she moved to the Imperial Cancer Research Fund, later the Cancer Research UK London Research Institute (and now part of the Francis Crick Institute) and in 2006 developed her interest in autophagy and the biogenesis of autophagosomes.
Her lab has identified several mammalian Atg proteins since 2006 and continues to contribute to understanding of autophagy at the molecular cell biology level.
Qualifications and history
Research topics
- Biochemistry & Proteomics (82)
- Cell Biology (82)
- Cell Cycle & Chromosomes (2)
- Chemical Biology & High Throughput (82)
- Computational & Systems Biology (9)
- Developmental Biology (1)
- Gene Expression (1)
- Genetics & Genomics (5)
- Genome Integrity & Repair (6)
- Human Biology & Physiology (1)
- Imaging (82)
- Immunology (3)
- Infectious Disease (3)
- Metabolism (2)
- Microfabrication & Bioengineering (1)
- (-)Model Organisms (82)
- Neurosciences (1)
- Signalling & Oncogenes (82)
- Stem Cells (1)
- Structural Biology & Biophysics (11)
- Synthetic Biology (1)
- Tumour Biology (4)
Publication type
Journal
- Autophagy (17)
- Autophagy Reports (2)
- Biology (1)
- Biology of the Cell (1)
- Bioscience Reports (1)
- BMC Biology (1)
- Brain (1)
- Brain Communications (1)
- Cancer Research (1)
- Cell (1)
- Cell Cycle (1)
- Cell Discovery (1)
- Computational and Structural Biotechnology Journal (1)
- Current Biology (1)
- Current Opinion in Cell Biology (1)
- eLife (2)
- EMBO Journal (2)
- EMBO Reports (1)
- FASEB BioAdvances (1)
- FEBS Letters (1)
- Frontiers in Oncology (1)
- Immunity (1)
- Journal of Biological Chemistry (1)
- Journal of Cell Biology (4)
- Journal of Cell Science (1)
- Journal of Molecular Biology (2)
- Journal of Visualized Experiments (1)
- Life Science Alliance (1)
- Methods in Enzymology (2)
- Methods in Molecular Biology (2)
- Mol Cell (1)
- Molecular Cell (3)
- Nature Cell Biology (1)
- Nature Communications (3)
- Nature Reviews Molecular Cell Biology (1)
- Science (1)
- Science advances (1)
- Scientific Reports (2)
- Small GTPases (1)
- The EMBO Journal (2)
- The FASEB Journal (1)
- Traffic (6)
- Transcription (1)
- Trends in Biochemical Sciences (1)
- Trends in Cell Biology (2)