Simeon Mihaylov

Principal Laboratory Research Scientist

Ultanir lab

Kinases and Brain Development Laboratory

Email Address: Crick email

Email

Qualifications and history

2017

University of Sheffield, UK

PhD

2018

King's College London, UK

Postdoc

2018

The Francis Crick Institute, London, UK

Postdoc

Displaying 1 - 15 of 15

Last updated : 15 August 2026 02:10

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

Authors (10)

Rebecca Morrison
Simeon Mihaylov
Jakson Luk
Cyril Lemerle
Angela Rodgers
Natalia Athanasiadi
Huw R Morris
Enrica Pellegrino
Sila Ultanir
Maximiliano Gutierrez

Journal of Cell Science

Published 15 July 2026

Crick labs/ facilities

Full details

The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex

Authors (12)

Marie Girodengo
Simeon Mihaylov
Katarzyna Klonowska
Laura Mantoan Ritter
Helen R Flynn
Mark Skehel
[...]
Eleonora Aronica
Matthew White
David J Kwiatkowski
Sila Ultanir
Joseph M Bateman

Acta Neuropathologica

Published 20 May 2026

Crick labs/ facilities

Full details

PRIDE entry PXD069405: Phosphoproteomics reveals altered RNA splicing as a major potential driver of pathology in the brain in tuberous sclerosis complex

Authors (2)

PRoteomics IDEntifications database (PRIDE)

Published 13 April 2026

Crick labs/ facilities

Full details

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development

Preprint

Authors (21)

Simeon Mihaylov
Andre Teixeira Lopes
Margaux Silvestre
Gaia Bianchini
Helen R Flynn
Almaz Huseynova
[...]
Marcel Köhn
Mark Skehel
Jernej Ule
Florencia Iacaruso
Sila Ultanir

bioRxiv

Published 7 April 2026

Crick labs/ facilities

Full details

mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node

Authors (43)

Laura Mantoan Ritter
Nicholas MP Annear
Emma L Baple
Leila Y Ben-Chaabane
Istvan Bodi
Lauren Brosson
[...]
Sila Ultanir
Bart Vanhaesebroeck
Benjamin Zare
Deb K Pal
Joseph M Bateman

Orphanet Journal of Rare Diseases

Published 27 May 2025

Crick labs

Sila Ultanir

Full details

Prenatal sodium channel dysfunction in Dravet syndrome alters cortical development

Preprint

Authors (25)

Clara Zourray
James Mills
Georgina Mills
Martina Mainardi
James Street
Joanna Bartkiewicz
[...]
Sanjay Sisodiya
Manju Kurian
Gaia Colasante
Serena Barral
Gabriele Lignani

Research Square

Published 9 May 2025

Crick labs/ facilities

Full details

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

Authors (11)

Jianzhi Jiang
Brent Wilkinson
Ilse Flores
Nicolas Hartel
Simeon Mihaylov
Veronica A Clementel
Helen R Flynn
Fowsan S Alkuraya
Sila Ultanir
Nicholas A Graham
Marcelo P Coba

Frontiers in Molecular Neuroscience

Published 4 April 2024

Crick labs/ facilities

Full details

Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain

Authors (5)

Molecular Psychiatry

Published 1 June 2024

Crick labs/ facilities

Full details

Data associated with "Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain"

Authors (5)

Figshare

Published 15 January 2024

Crick labs/ facilities

Full details

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Authors (10)

Marisol Sampedro Castaneda
Lucas Baltussen
Andre Teixeira Lopes
Yichen Qiu
Liina Sirvio
Simeon Mihaylov
Suzanne Claxton
Jill C Richardson
Gabriele Lignani
Sila Ultanir

Nature Communications

Published 11 December 2023

Crick labs/ facilities

Full details

LRRK2 kinase dependent and independent function on endolysosomal repair promotes macrophage cell death

Preprint

Authors (9)

Rebecca Morrison
Simeon Mihaylov
Jakson Luk
Angela Rodgers
Natalia Athanasiadi
Huw R Morris
Enrica Pellegrino
Sila Ultanir
Maximiliano Gutierrez

bioRxiv

Published 27 September 2023

Crick labs

Full details

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Authors (16)

Simeon Mihaylov
Lydia M Castelli
Ya-Hui Lin
Aytac Gül
Nikita Soni
Christopher Hastings
[...]
Oliver Bandmann
Tatyana A Shelkovnikova
Heather Mortiboys
Sila Ultanir
Guillaume M Hautbergue

Nature Communications

Published 7 September 2023

Crick labs/ facilities

Full details

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

Authors (9)

Pranetha Baskaran
Simeon Mihaylov
Elin Vinsland
Kriti Shah
Lucy Granat
Sila Ultanir
Andrew R Tee
Jernej Murn
Joseph M Bateman

Journal of Biological Chemistry

Published 1 January 2023

Crick labs

Sila Ultanir

Full details

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Authors (14)

Flavia Roşianu
Simeon Mihaylov
Noreen Eder
Antonie Martiniuc
Suzanne Claxton
Helen R Flynn
[...]
Mark Skehel
Bram Snijders
Matthias Krause
Sharon Tooze
Sila Ultanir

Life Science Alliance

Published 1 February 2023

Crick labs/ facilities

Full details

Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA

Authors (12)

Bram Snijders
Guillaume M Hautbergue
Alex Bloom
James C Williamson
Thomas C Minshull
Helen L Phillips
[...]
Douglas T Gjerde
David P Hornby
Stuart A Wilson
Paul J Hurd
Mark J Dickman

RNA

Published 1 March 2015

Crick labs/ facilities

Proteomics

Full details

Research partnerships

Technical training

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Simeon Mihaylov

Principal Laboratory Research Scientist

Ultanir lab

Qualifications and history

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex

PRIDE entry PXD069405: Phosphoproteomics reveals altered RNA splicing as a major potential driver of pathology in the brain in tuberous sclerosis complex

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development

mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node

Prenatal sodium channel dysfunction in Dravet syndrome alters cortical development

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain

Data associated with "Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain"

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

LRRK2 kinase dependent and independent function on endolysosomal repair promotes macrophage cell death

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA

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