Stefania Crotta

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Authors (8)

Stefania Crotta
Matteo Villa
Jack Major
Katja Finsterbusch
Miriam Llorian
Peter Carmeliet
Joerg Buescher
Andreas Wack

Nature Communications

Published 13 February 2023

Crick labs/ facilities

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Impaired immune response drives age-dependent severity of COVID-19

Authors (20)

Julius Beer
Stefania Crotta
Angele Breithaupt
Annette Ohnemus
Jan Becker
Benedikt Sachs
[...]
Jonas Fuchs
Georg Kochs
Andreas Wack
Martin Schwemmle
Daniel Schnepf

Journal of Experimental Medicine

Published 5 December 2022

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Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Authors (18)

Peter AC Wing
Maria Prange-Barczynska
Amy Cross
Stefania Crotta
Claudia Orbegozo Rubio
Xiaotong Cheng
[...]
Peter Balfe
Andreas Wack
Tammie Bishop
Francisco J Salguero
Jane A McKeating

PLOS Pathogens

Published 6 September 2022

Crick labs

Andreas Wack

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Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Authors (18)

Science Immunology

Published 5 November 2021

Crick labs/ facilities

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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

Authors (12)

Jacob Thyrsted
Jacob Storgaard
Julia Blay-Cadanet
Alexander Heinz
Anne Laugaard Thielke
Stefania Crotta
[...]
David Olagnier
Andreas Wack
Karsten Hiller
Anne Louise Hansen
Christian Kanstrup Holm

iScience

Published 19 November 2021

Crick labs

Andreas Wack

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A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza

Authors (6)

Julie Rappe
Katja Finsterbusch
Stefania Crotta
Matthias Mack
Simon L Priestnall
Andreas Wack

Journal of Experimental Medicine

Published 1 November 2021

Crick labs/ facilities

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The interferon landscape along the respiratory tract impacts the severity of COVID-19

Authors (28)

Benedetta Sposito
Achille Broggi
Laura Pandolfi
Stefania Crotta
Nicola Clementi
Roberto Ferrarese
[...]
Antonio E Pontiroli
Federica Meloni
Andreas Wack
Nicasio Mancini
Ivan Zanoni

Cell

Published 16 September 2021

Crick labs

Andreas Wack

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Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

Authors (15)

Daniel Schnepf
Pedro Hernandez
Tanel Mahlakõiv
Stefania Crotta
Meagan E Sullender
Stefan T Peterson
[...]
Celso A Reis
Andreas Diefenbach
Andreas Wack
Megan T Baldridge
Peter Staeheli

PLOS ONE

Published 12 August 2021

Crick labs

Andreas Wack

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Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses

Authors (17)

Daniel Schnepf
Stefania Crotta
Thiprampai Thamamongood
Megan Stanifer
Laura Polcik
Annette Ohnemus
[...]
Susanne Kirschnek
Steeve Boulant
Martin Schwemmle
Andreas Wack
Peter Staeheli

Science Immunology

Published 14 May 2021

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Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Authors (8)

Jack Major
Stefania Crotta
Miriam Llorian
Teresa M McCabe
Hans Henrik Gad
Simon L Priestnall
Rune Hartmann
Andreas Wack

Science

Published 7 August 2020

Crick labs/ facilities

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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Authors (9)

Helena Aegerter
Justina Kulikauskaite
Stefania Crotta
Harshil Patel
Gavin Kelly
Edith M Hessel
Matthias Mack
Soren Beinke
Andreas Wack

Nature Immunology

Published 1 February 2020

Crick labs/ facilities

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Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection

Authors (9)

Konrad Bradley
Katja Finsterbusch
Daniel Schnepf
Stefania Crotta
Miriam Llorian
Sophia Davidson
Serge Y Fuchs
Peter Staeheli
Andreas Wack

Cell Reports

Published 2 July 2019

Crick labs/ facilities

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The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity

Authors (10)

Immunity

Published 21 August 2018

Crick labs/ facilities

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The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Authors (9)

Matteo Villa
Stefania Crotta
Kevin S Dingwell
Elizabeth MA Hirst
Manolis Gialitakis
Helena Ahlfors
Jim Smith
Brigitta Stockinger
Andreas Wack

Nature Communications

Published 26 August 2016

Crick labs/ facilities

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IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment

Authors (8)

Sophia Davidson
Teresa M McCabe
Stefania Crotta
Hans Henrik Gad
Edith M Hessel
Soren Beinke
Rune Hartmann
Andreas Wack

EMBO Molecular Medicine

Published 1 September 2016

Crick labs/ facilities

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TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

Authors (6)

Gregory T Ellis
Sophia Davidson
Stefania Crotta
Nora Branzk
Venizelos Papayannopoulos
Andreas Wack

EMBO Reports

Published 1 September 2015

Crick labs/ facilities

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A serpin shapes the extracellular environment to prevent influenza A virus maturation

Authors (15)

Meike Dittmann
Hans-Heinrich Hoffmann
Margaret A Scull
Rachel H Gilmore
Kierstin L Bell
Michael Ciancanelli
[...]
Jing W Xiao
Jean-Laurent Casanova
Andreas Wack
Paul D Bieniasz
Charles M Rice

Cell

Published 12 February 2015

Crick labs

Andreas Wack

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The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development

Authors (8)

Stefania Crotta
Annita Gkioka
Victoria Male
João H Duarte
Sophia Davidson
Ilaria Nisoli
Hugh JM Brady
Andreas Wack

Journal of Immunology

Published 17 February 2014

Crick labs

Andreas Wack

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Pathogenic potential of interferon αβ in acute influenza infection

Authors (4)

Sophia Davidson
Stefania Crotta
Teresa M McCabe
Andreas Wack

Nature Communications

Published 1 January 2014

Crick labs

Andreas Wack

Full details

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

Authors (8)

Stefania Crotta
Sophia Davidson
Tanel Mahlakoiv
Christophe J Desmet
Matthew R Buckwalter
Matthew L Albert
Peter Staeheli
Andreas Wack

PLOS Pathogens

Published 1 November 2013

Crick labs

Andreas Wack

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Research case studies

PhD student recruitment

Cut + Paste exhibition

Coronavirus (COVID-19) research

About us

Stefania Crotta

SENIOR LABORATORY RESEARCH SCIENTIST

Wack lab

Year published

Research topics

Publication type

Journal

Crick Pre-Crick

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Impaired immune response drives age-dependent severity of COVID-19

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza

The interferon landscape along the respiratory tract impacts the severity of COVID-19

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection

The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment

TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

A serpin shapes the extracellular environment to prevent influenza A virus maturation

The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development

Pathogenic potential of interferon αβ in acute influenza infection

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

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