Stefania Crotta

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Authors (18)

Mar Cabeza Cabrerizo
Carlos Munoz Minutti
Ana Matos Cardoso Da Silva
Rob Jenkins
Justina Kulikauskaite
Michael Buck
[...]
Caetano Reis e Sousa
Mariana Pereira da Costa
Hector Huerga Encabo
Judith E Allen
Manolis Pasparakis

Science Immunology

Published 5 November 2021

Crick labs/ facilities

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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

Authors (12)

Stefania Crotta
Andreas Wack
Jacob Thyrsted
Jacob Storgaard
Julia Blay-Cadanet
Alexander Heinz
[...]
Frank de Paoli
David Olagnier
Karsten Hiller
Anne Louise Hansen
Christian Kanstrup Holm

iScience

Published 19 November 2021

Crick labs

Andreas Wack

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A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza

Authors (6)

Julie Rappe
Katja Finsterbusch
Stefania Crotta
Simon L Priestnall
Andreas Wack
Matthias Mack

Journal of Experimental Medicine

Published 1 November 2021

Crick labs/ facilities

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The interferon landscape along the respiratory tract impacts the severity of COVID-19

Authors (28)

Stefania Crotta
Andreas Wack
Benedetta Sposito
Achille Broggi
Laura Pandolfi
Nicola Clementi
[...]
Janet Chou
Antonio E Pontiroli
Federica Meloni
Nicasio Mancini
Ivan Zanoni

Cell

Published 16 September 2021

Crick labs

Andreas Wack

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Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

Authors (15)

Stefania Crotta
Andreas Wack
Daniel Schnepf
Pedro Hernandez
Tanel Mahlakõiv
Meagan E Sullender
[...]
Laure Dumoutier
Celso A Reis
Andreas Diefenbach
Megan T Baldridge
Peter Staeheli

PLOS ONE

Published 12 August 2021

Crick labs

Andreas Wack

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Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses

Authors (17)

Stefania Crotta
Miriam Llorian
Andreas Wack
Daniel Schnepf
Thiprampai Thamamongood
Megan Stanifer
[...]
Birgit Strobl
Susanne Kirschnek
Steeve Boulant
Martin Schwemmle
Peter Staeheli

Science Immunology

Published 14 May 2021

Crick labs/ facilities

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Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Authors (8)

Jack Major
Stefania Crotta
Miriam Llorian
Teresa M McCabe
Simon L Priestnall
Andreas Wack
Hans Henrik Gad
Rune Hartmann

Science

Published 7 August 2020

Crick labs/ facilities

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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Authors (9)

Helena Aegerter
Justina Kulikauskaite
Stefania Crotta
Harshil Patel
Gavin Kelly
Andreas Wack
Edith M Hessel
Matthias Mack
Soren Beinke

Nature Immunology

Published 1 February 2020

Crick labs/ facilities

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Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection

Authors (9)

Konrad Bradley
Katja Finsterbusch
Stefania Crotta
Miriam Llorian
Sophia Davidson
Andreas Wack
Daniel Schnepf
Serge Y Fuchs
Peter Staeheli

Cell Reports

Published 2 July 2019

Crick labs/ facilities

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The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity

Authors (10)

Immunity

Published 21 August 2018

Crick labs/ facilities

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The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Authors (8)

Matteo Villa
Stefania Crotta
Kevin S Dingwell
Elizabeth MA Hirst
Manolis Gialitakis
Jim Smith
Brigitta Stockinger
Andreas Wack

Nature Communications

Published 26 August 2016

Crick labs/ facilities

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IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment

Authors (8)

Sophia Davidson
Teresa M McCabe
Stefania Crotta
Andreas Wack
Hans Henrik Gad
Edith M Hessel
Soren Beinke
Rune Hartmann

EMBO Molecular Medicine

Published 1 September 2016

Crick labs/ facilities

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TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

Authors (6)

Sophia Davidson
Stefania Crotta
Nora Branzk
Venizelos Papayannopoulos
Andreas Wack
Gregory T Ellis

EMBO Reports

Published 1 September 2015

Crick labs/ facilities

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A serpin shapes the extracellular environment to prevent influenza A virus maturation

Authors (15)

Stefania Crotta
Andreas Wack
Meike Dittmann
Hans-Heinrich Hoffmann
Margaret A Scull
Rachel H Gilmore
[...]
Brenna Flatley
Jing W Xiao
Jean-Laurent Casanova
Paul D Bieniasz
Charles M Rice

Cell

Published 12 February 2015

Crick labs

Andreas Wack

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The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development

Authors (2)

Journal of Immunology

Published 17 February 2014

Crick labs

Andreas Wack

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Pathogenic potential of interferon αβ in acute influenza infection

Authors (4)

Stefania Crotta
Andreas Wack
Sophia Davidson
Teresa M McCabe

Nature Communications

Published 1 January 2014

Crick labs

Andreas Wack

Full details

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

Authors (8)

Stefania Crotta
Andreas Wack
Sophia Davidson
Tanel Mahlakoiv
Christophe J Desmet
Matthew R Buckwalter
Matthew L Albert
Peter Staeheli

PLOS Pathogens

Published 1 November 2013

Crick labs

Andreas Wack

Full details

Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection

Authors (2)

Journal of hepatology

Published 1 February 2010

Crick labs

Andreas Wack

Full details

Research case studies

Vacancies

Pathway to Discovery

Coronavirus (COVID-19) research

About us

Stefania Crotta

SENIOR LABORATORY RESEARCH SCIENTIST

Wack lab

Year published

Research topics

Publication type

Journal

Crick Pre-Crick

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza

The interferon landscape along the respiratory tract impacts the severity of COVID-19

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection

The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment

TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

A serpin shapes the extracellular environment to prevent influenza A virus maturation

The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development

Pathogenic potential of interferon αβ in acute influenza infection

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection

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