Stefania Crotta

Diverse lung challenges elicit a conserved monocyte-to-macrophage differentiation blueprint

Preprint

Authors (15)

Chrysante Iliakis
Wouter T’Jonck
Isobel C Mouat
Sam Bankole
Jiawei Liang
Gareth-Rhys Jones
[...]
Simon Priestnall
Alejandro Suárez-Bonnet
Jürgen Schwarze
Andreas Wack
Calum C Bain

bioRxiv

Published 17 March 2026

Crick labs/ facilities

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The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors

Preprint

Authors (12)

Timo Oosenbrug
Dennis Gravekamp
Adán Pinto-Fernández
Stefania Crotta
Katja Finsterbusch
Sander B van der Kooij
[...]
Yanniek Asschert
Gilaine FE Kleian
Benedikt M Kessler
Andreas Wack
Annemarthe G van der Veen

bioRxiv

Published 1 April 2025

Crick labs

Andreas Wack

Full details

The interplay between innate immunity and nonimmune cells in lung damage, inflammation, and repair

Authors (3)

Annual Review of Immunology

Published 1 April 2025

Crick labs

Andreas Wack

Full details

The FAM13A long isoform regulates cilia movement and
coordination in airway mucociliary transport

Authors (31)

Ashleigh Howes
Clare Rogerson
Nikolai Belyaev
Tina Karagyozova
Radu Rapiteanu
Ricardo Fradique
[...]
Louise Walport
Pietro Cicuta
Andrew J Powell
Soren Beinke
Andreas Wack

American Journal of Respiratory Cell and Molecular Biology

Published 1 September 2024

Crick labs/ facilities

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Endothelial AHR activity prevents lung barrier disruption in viral infection

Authors (13)

Jack Major
Stefania Crotta
Katja Finsterbusch
Probir Chakravarty
Kathleen Shah
Bruno Frederico
[...]
Lucy Meader
Alejandro Suarez-Bonnet
Simon Priestnall
Brigitta Stockinger
Andreas Wack

Nature

Published 28 September 2023

Crick labs/ facilities

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Type I interferons drive MAIT cell functions against
bacterial pneumonia

Authors (12)

Juan Carlos Lopez-Rodriguez
Steven J Hancock
Kelin Li
Stefania Crotta
Christopher Barrington
Alejandro Suárez-Bonnet
[...]
Jeffrey Aubé
Andreas Wack
Paul Klenerman
Jose A Bengoechea
Patricia Barral

Journal of Experimental Medicine

Published 2 October 2023

Crick labs/ facilities

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GEO entry GSE203427: Aryl hydrocarbon receptor (AHR)-dependent protection against lung vascular leakage in viral infection

Authors (3)

Gene Expression Omnibus (GEO)

Published 23 May 2023

Crick labs/ facilities

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GEO entry GSE225958: AHR protects against lung vascular leakage in viral infection

Authors (3)

Gene Expression Omnibus (GEO)

Published 23 May 2023

Crick labs/ facilities

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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Authors (8)

Stefania Crotta
Matteo Villa
Jack Major
Katja Finsterbusch
Miriam Llorian Sopena
Peter Carmeliet
Joerg Buescher
Andreas Wack

Nature Communications

Published 13 February 2023

Crick labs/ facilities

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Impaired immune response drives age-dependent severity of COVID-19

Authors (20)

Julius Beer
Stefania Crotta
Angele Breithaupt
Annette Ohnemus
Jan Becker
Benedikt Sachs
[...]
Jonas Fuchs
Georg Kochs
Andreas Wack
Martin Schwemmle
Daniel Schnepf

Journal of Experimental Medicine

Published 5 December 2022

Crick labs/ facilities

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Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Authors (18)

Peter AC Wing
Maria Prange-Barczynska
Amy Cross
Stefania Crotta
Claudia Orbegozo Rubio
Xiaotong Cheng
[...]
Peter Balfe
Andreas Wack
Tammie Bishop
Francisco J Salguero
Jane A McKeating

PLOS Pathogens

Published 6 September 2022

Crick labs

Andreas Wack

Full details

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Preprint

Authors (18)

Peter AC Wing
Maria Prange-Barczynska
Amy Cross
Stefania Crotta
Claudia Orbegozo Rubio
Xiaotong Cheng
[...]
Peter Balfe
Andreas Wack
Tammie Bishop
Francisco J Salguero
Jane A McKeating

bioRxiv

Published 15 March 2022

Crick labs

Andreas Wack

Full details

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Authors (18)

Maria Del Mar Cabeza Cabrerizo
Carlos Munoz Minutti
Mariana Pereira da Costa
Ana Cardoso
Rob Jenkins
Justina Kulikauskaite
[...]
Judith E Allen
Manolis Pasparakis
Andreas Wack
Erik Sahai
Caetano Reis e Sousa

Science Immunology

Published 5 November 2021

Crick labs/ facilities

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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

Authors (12)

Jacob Thyrsted
Jacob Storgaard
Julia Blay-Cadanet
Alexander Heinz
Anne Laugaard Thielke
Stefania Crotta
[...]
David Olagnier
Andreas Wack
Karsten Hiller
Anne Louise Hansen
Christian Kanstrup Holm

iScience

Published 19 November 2021

Crick labs

Andreas Wack

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A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza

Authors (6)

Journal of Experimental Medicine

Published 1 November 2021

Crick labs/ facilities

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The interferon landscape along the respiratory tract impacts the severity of COVID-19

Authors (28)

Benedetta Sposito
Achille Broggi
Laura Pandolfi
Stefania Crotta
Nicola Clementi
Roberto Ferrarese
[...]
Antonio E Pontiroli
Federica Meloni
Andreas Wack
Nicasio Mancini
Ivan Zanoni

Cell

Published 16 September 2021

Crick labs

Andreas Wack

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Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

Authors (15)

Daniel Schnepf
Pedro Hernandez
Tanel Mahlakõiv
Stefania Crotta
Meagan E Sullender
Stefan T Peterson
[...]
Celso A Reis
Andreas Diefenbach
Andreas Wack
Megan T Baldridge
Peter Staeheli

PLOS ONE

Published 12 August 2021

Crick labs

Andreas Wack

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Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses

Authors (17)

Daniel Schnepf
Stefania Crotta
Thiprampai Thamamongood
Megan Stanifer
Laura Polcik
Annette Ohnemus
[...]
Susanne Kirschnek
Steeve Boulant
Martin Schwemmle
Andreas Wack
Peter Staeheli

Science Immunology

Published 14 May 2021

Crick labs/ facilities

Full details

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Authors (8)

Jack Major
Stefania Crotta
Miriam Llorian Sopena
Teresa M McCabe
Hans Henrik Gad
Simon Priestnall
Rune Hartmann
Andreas Wack

Science

Published 7 August 2020

Crick labs/ facilities

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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Authors (9)

Helena Aegerter
Justina Kulikauskaite
Stefania Crotta
Harshil Patel
Gavin Kelly
Edith M Hessel
Matthias Mack
Soren Beinke
Andreas Wack

Nature Immunology

Published 1 February 2020

Crick labs/ facilities

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Stefania Crotta

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Diverse lung challenges elicit a conserved monocyte-to-macrophage differentiation blueprint

The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors

The interplay between innate immunity and nonimmune cells in lung damage, inflammation, and repair

The FAM13A long isoform regulates cilia movement and
coordination in airway mucociliary transport

Endothelial AHR activity prevents lung barrier disruption in viral infection

Type I interferons drive MAIT cell functions against
bacterial pneumonia

GEO entry GSE203427: Aryl hydrocarbon receptor (AHR)-dependent protection against lung vascular leakage in viral infection

GEO entry GSE225958: AHR protects against lung vascular leakage in viral infection

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Impaired immune response drives age-dependent severity of COVID-19

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza

The interferon landscape along the respiratory tract impacts the severity of COVID-19

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

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