Stefania Federico

Senior Laboratory Research Scientist in the Peptide Chemistry Laboratory

The Peptide Chemistry STP supports chemistry at the Francis Crick Institute by synthesising small molecules, peptides and peptide arrays.

EDUCATION:

Master Degree in Chemistry and Pharmaceutical Technology (November 1999 – May 2006) – Faculty of Pharmacy, University of Calabria, Italy.

Experimental Thesis: “Study of membranes process for the purification of macromolecules with biological activity” – Institute of Membrane Technology (ITM-CNR), Cosenza, Italy.

Ph.D. Student in Materials for Life Science (April 2007 – November 2011), Faculty of Mathematics and Natural Science, University of Potsdam, Germany.

Dissertation title: “Synthetic Peptides Derived from Decorin as Building Blocks for Biomaterials Based on Supramolecular Interactions” – Helmholtz-Zentrum Geesthacht (HZG), Germany.

Ph.D. Defense (April 2012)

Scientific Officer, Peptide Synthesis Laboratory, Lincoln Inn’s Field (LRI) (October 2012) promoted to Senior Scientific Officer (April 2014)

My interest is to work in the field of proteins and peptides as they are valuable tools for biomedical studies, whilst working in an interdisciplinary environment, involving chemistry and biology.

PUBLICATIONS:

Design of Decorin-Based Peptides That Bind to Collagen I and their Potential as Adhesion Moieties in Biomaterials

S. Federico, B.F. Pierce, S. Piluso, C. Wischke, A. Lendlein, A.T. Neffe, Angewandte Chemie International Edition, 2015, 54(37):10980-4. DOI: 10.1002/anie.201505227

Synthesis and Characterization of a Telechelic Peptide as a Precursor for Supramolecular Networks

S. Federico, A. Lendlein, A.T. Neffe, Macromolecular Symposia, 2011, 309/310, 205.  DOI: 10.1002/masy.2011000

Supramolecular Hydrogel Networks Formed by Molecular Recognition of Collagen and a Peptide Grafted to Hyaluronic Acid

S. Federico, U. Nochel, C. Lowenberg, A. Lendlein, A.T. Neffe, Acta Biomaterialia, 2016, 38:1-10. DOI: 10.1016/j.actbio.2016.04.018

Secondary Structure of Decorin-Derived Peptides in Solution

A.T. Neffe, S. Federico, A. Lendlein, Biomaterials and Soft Materials, Volume 1, Issue 27, 2016, pp 1965-1970. DOI: 10.1557/adv.2016.266

Structural Basis of Eco1-Mediated Cohesin Acetylation

Chao WC, Wade BO, Bouchoux C, Jones AW, Purkiss AG, Federico S, O'Reilly N, Snijders AP, Uhlmann F, Singleton MR, Sci Rep. 2017 Apr 11;7:46382. DOI: 10.1038/srep44313

Global profiling of myristoylation in Toxoplasma gondii reveals key roles for lipidation in CDPK1 and MIC7 functionMalgorzata Broncel, Caia Dominicus, Alexander Hunt, Bethan Wallbank, Stefania Federico, Joanna Young, Moritz Treeck,  http://dx.doi.org/10.1101/719062