Steven Hooper

Emergent mechanical control of vascular morphogenesis

Authors (29)

Jordan Whisler
Somayeh Shahreza
Karin Schlegelmilch
Nil Ege
Yousef Javanmardi
Andrea Malandrino
[...]
Fernando Calvo
Christiana Ruhrberg
Erik Sahai
Roger Kamm
Emad Moeendarbary

Science advances

Published 11 August 2023

Crick labs/ facilities

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Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

Authors (12)

Takuya Kato
Rob Jenkins
Stefanie Derzsi
Melda Tozluoglu
Toni Rullan Iriarte
Steven Hooper
[...]
Holly Joyce
Xiao Fu
Selvam Thavaraj
Paul Bates
Erik Sahai

eLife

Published 9 March 2023

Crick labs/ facilities

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EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

Authors (11)

Manuela Zangrossi
Patrizia Romani
Probir Chakravarty
Colin Ratcliffe
Steven Hooper
Martina Dori
Mattia Forcato
Silvio Bicciato
Sirio Dupont
Erik Sahai
Marco Montagner

Cancers

Published 3 March 2021

Crick labs/ facilities

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A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells

Authors (7)

Manuela Zangrossi
Probir Chakravarty
Patrizia Romani
Sirio Dupont
Steven Hooper
Erik Sahai
Marco Montagner

Cancers (Basel)

Published 28 February 2021

Crick labs/ facilities

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Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Authors (9)

Cell Reports

Published 16 February 2021

Crick labs/ facilities

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STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

Authors (10)

Esther Arwert
Emma Milford
Toni Rullan Iriarte
Stefanie Derzsi
Steven Hooper
Takuya Kato
David Mansfield
Alan Melcher
Kevin J Harrington
Erik Sahai

Nature Cell Biology

Published 1 July 2020

Crick labs/ facilities

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Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Authors (12)

Marco Montagner
Rahul Bhome
Steven Hooper
Probir Chakravarty
Xiao Qin
Jahangir Sufi
[...]
Colin Ratcliffe
Yutaka Naito
Arianna Pocaterra
Christopher J Tape
Erik Sahai

Nature Cell Biology

Published 1 March 2020

Crick labs/ facilities

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Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukaemia cells from oxidative stress

Authors (23)

Richard Burt
Aditi Dey
Sarah Aref
Melanie Aguiar
Ayse Akarca
Katharine Bailey
[...]
Constandina Pospori
Ignazio Puccio
Krisztina Zuborne-Alapi
Erik Sahai
Adele K Fielding

Blood

Published 24 October 2019

Crick labs

Erik Sahai

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Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

Authors (8)

Hugh Sparks
Hiroshi Kondo
Steven Hooper
Ian Munro
Gordon Kennedy
Christopher Dunsby
Paul French
Erik Sahai

Nature Communications

Published 9 July 2018

Crick labs/ facilities

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Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export

Authors (8)

Cell systems

Published 27 June 2018

Crick labs/ facilities

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Cdc42EP3/BORG2 and septin network enables mechano-transduction and the emergence of cancer-associated fibroblasts

Authors (9)

Fernando Calvo
Romana Ranftl
Steven Hooper
Aaron J Farrugia
Emad Moeendarbary
Andreas Bruckbauer
Facundo Batista
Guillaume Charras
Erik Sahai

Cell Reports

Published 29 December 2015

Crick labs

Erik Sahai

Full details

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling

Authors (9)

Eishu Hirata
Maria Romina Girotti
Amaya Viros
Steven Hooper
Bradley Spencer-Dene
Michiyuki Matsuda
James Larkin
Richard Marais
Erik Sahai

Cancer Cell

Published 13 April 2015

Crick labs/ facilities

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Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

Authors (11)

Amine Sadok
Afshan Mccarthy
John Caldwell
Ian Collins
Michelle D Garrett
Maggie Yeo
Steven Hooper
Erik Sahai
Sandra Kuemper
Faraz K Mardakheh
Christopher J Marshall

Cancer Research

Published 1 June 2015

Crick labs

Erik Sahai

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STRIPAK components determine mode of cancer cell migration and metastasis

Authors (9)

Chris D Madsen
Steven Hooper
Melda Tozluoglu
Andreas Bruckbauer
Georgina Fletcher
Janine T Erler
Paul Bates
Barry Thompson
Erik Sahai

Nature Cell Biology

Published 1 January 2015

Crick labs

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Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells

Authors (3)

Oncogene

Published 10 November 2014

Crick labs

Erik Sahai

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Dendritic cells control fibroblastic reticular network tension and lymph node expansion

Authors (16)

Sophie E Acton
Aaron J Farrugia
Jillian L Astarita
Diego Mourão-Sá
Rob Jenkins
Emma Nye
[...]
Luis F Moita
Gordon Stamp
Shannon J Turley
Erik Sahai
Caetano Reis e Sousa

Nature

Published 23 October 2014

Crick labs/ facilities

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Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions

Authors (6)

Melda Tozluoğlu
Alexander L Tournier
Rob Jenkins
Steven Hooper
Paul Bates
Erik Sahai

Nature Cell Biology

Published 1 July 2013

Crick labs

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Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Authors (11)

Fernando Calvo
Nil Ege
Araceli Grande-Garcia
Steven Hooper
Rob Jenkins
Shahid I Chaudhry
Kevin Harrington
Peter Williamson
Emad Moeendarbary
Guillaume Charras
Erik Sahai

Nature Cell Biology

Published 1 June 2013

Crick labs

Erik Sahai

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Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

Authors (16)

Raghu Kadaba
Hanna Birke
Jun Wang
Steven Hooper
Claudia D Andl
Francesco Di Maggio
[...]
Anil K Rustgi
Erik Sahai
Claude Chelala
Peter Sasieni
Hemant M Kocher

Journal of Pathology

Published 1 May 2013

Crick labs

Erik Sahai

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Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts

Authors (6)

SI Chaudhry
Steven Hooper
Emma Nye
P Williamson
K Harrington
Erik Sahai

Oncogene

Published 7 February 2013

Crick labs/ facilities

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Crick Pre-Crick

Emergent mechanical control of vascular morphogenesis

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukaemia cells from oxidative stress

Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export

Cdc42EP3/BORG2 and septin network enables mechano-transduction and the emergence of cancer-associated fibroblasts

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

STRIPAK components determine mode of cancer cell migration and metastasis

Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts

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