Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Research A Z researchers Suzanne Claxton Senior Laboratory Research Scientist Ultanir lab Kinases and Brain Development Laboratory Year published2024 (1)2023 (2)2020 (1)2018 (2)2014 (1)2013 (1)2011 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (4)Cell Biology (5)Chemical Biology & High Throughput (5)Computational & Systems Biology (4)Developmental Biology (5)Genetics & Genomics (1)Genome Integrity & Repair (1)Imaging (2)Model Organisms (2)Neurosciences (6)Signalling & Oncogenes (5)Tumour Biology (1) Facet Research topicsPublication type (-)Journal article (9)Primary research (9) Facet Publication typeJournalDisease Models & Mechanisms (1)EMBO Journal (1)Journal of Neuroscience (1)Life Science Alliance (2)Molecular Psychiatry (1)Nature Communications (2)Neuron (1) Facet JournalCrick Pre-CrickCrick publications (9) Facet Crick Pre-Crick Displaying 1 - 9 of 9Last updated : 19 April 2024 02:58 Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain Authors (5)Margaux SilvestreKelvin DempsterSimeon MihaylovSuzanne ClaxtonSila Ultanir Molecular Psychiatry Published 8 February 2024 Crick labs/ facilitiesSila UltanirGenetic Modification ServiceBiological Research FacilityFull details Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability Authors (10)Marisol Sampedro CastanedaLucas BaltussenAndre Teixeira Lopes Yichen Qiu Liina SirvioSimeon MihaylovSuzanne Claxton Jill C Richardson Gabriele LignaniSila Ultanir Nature Communications Published 11 December 2023 Crick labs/ facilitiesSila UltanirProteomicsGenetic Modification ServiceBiological Research FacilityFull details Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration Authors (14) Flavia RoşianuSimeon MihaylovNoreen Eder Antonie MartiniucSuzanne Claxton Helen R Flynn[...]Mark SkehelBram Snijders Matthias KrauseSharon ToozeSila Ultanir Life Science Alliance Published 1 February 2023 Crick labs/ facilitiesSila UltanirSharon ToozeProteomicsElectron MicroscopyExperimental HistopathologyFull details YAP1/TAZ drives ependymoma-like tumour formation in mice Authors (15)Noreen Eder Federico Roncaroli Marie-Charlotte Dolmart Stuart Horswell Felipe Andreiuolo Helen Flynn[...] Jun-Hao Mao Torsten Pietsch Barry ThompsonBram SnijdersSila Ultanir Nature Communications Published 1 December 2020 Crick labs/ facilitiesSila UltanirBarry ThompsonProteomicsElectron MicroscopyBioinformatics and BiostatisticsFull details Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase Authors (10) Amy W Lin Kalbinder K GillMarisol Sampedro Castaneda Irene MatucciNoreen EderSuzanne Claxton Helen FlynnBram SnijdersRoger GeorgeSila Ultanir Life Science Alliance Published 31 December 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyGenetic Modification ServiceBiological Research FacilityFull details Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics Authors (10)Lucas Baltussen Priscilla D NegraesMargaux SilvestreSuzanne Claxton M Moeskops Evangelos Christodoulou Helen R FlynnBram Snijders Alysson R MuotriSila Ultanir EMBO Journal Published 28 September 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyFull details MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development Authors (9)Sila Ultanir Smita Yadav Nicholas T Hertz Juan A Oses-PrietoSuzanne Claxton Alma L Burlingame Kevan M Shokat Lily Y Jan Yuh-Nung Jan Neuron Published 1 January 2014 Crick labsSila UltanirFull details Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity Authors (9) Neal Anthwal Michelle PellingSuzanne Claxton Georg Mellitzer Caitlin Collin Nicoletta Kessaris William D Richardson Gérard GradwohlSiew-Lan Ang Disease Models & Mechanisms Published 1 January 2013Full details Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors Authors (5) Carol H Yan Martin LevesqueSuzanne Claxton Randy L JohnsonSiew-Lan Ang Journal of Neuroscience Published 31 August 2011Full details
Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain Authors (5)Margaux SilvestreKelvin DempsterSimeon MihaylovSuzanne ClaxtonSila Ultanir Molecular Psychiatry Published 8 February 2024 Crick labs/ facilitiesSila UltanirGenetic Modification ServiceBiological Research FacilityFull details
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability Authors (10)Marisol Sampedro CastanedaLucas BaltussenAndre Teixeira Lopes Yichen Qiu Liina SirvioSimeon MihaylovSuzanne Claxton Jill C Richardson Gabriele LignaniSila Ultanir Nature Communications Published 11 December 2023 Crick labs/ facilitiesSila UltanirProteomicsGenetic Modification ServiceBiological Research FacilityFull details
Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration Authors (14) Flavia RoşianuSimeon MihaylovNoreen Eder Antonie MartiniucSuzanne Claxton Helen R Flynn[...]Mark SkehelBram Snijders Matthias KrauseSharon ToozeSila Ultanir Life Science Alliance Published 1 February 2023 Crick labs/ facilitiesSila UltanirSharon ToozeProteomicsElectron MicroscopyExperimental HistopathologyFull details
YAP1/TAZ drives ependymoma-like tumour formation in mice Authors (15)Noreen Eder Federico Roncaroli Marie-Charlotte Dolmart Stuart Horswell Felipe Andreiuolo Helen Flynn[...] Jun-Hao Mao Torsten Pietsch Barry ThompsonBram SnijdersSila Ultanir Nature Communications Published 1 December 2020 Crick labs/ facilitiesSila UltanirBarry ThompsonProteomicsElectron MicroscopyBioinformatics and BiostatisticsFull details
Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase Authors (10) Amy W Lin Kalbinder K GillMarisol Sampedro Castaneda Irene MatucciNoreen EderSuzanne Claxton Helen FlynnBram SnijdersRoger GeorgeSila Ultanir Life Science Alliance Published 31 December 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyGenetic Modification ServiceBiological Research FacilityFull details
Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics Authors (10)Lucas Baltussen Priscilla D NegraesMargaux SilvestreSuzanne Claxton M Moeskops Evangelos Christodoulou Helen R FlynnBram Snijders Alysson R MuotriSila Ultanir EMBO Journal Published 28 September 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyFull details
MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development Authors (9)Sila Ultanir Smita Yadav Nicholas T Hertz Juan A Oses-PrietoSuzanne Claxton Alma L Burlingame Kevan M Shokat Lily Y Jan Yuh-Nung Jan Neuron Published 1 January 2014 Crick labsSila UltanirFull details
Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity Authors (9) Neal Anthwal Michelle PellingSuzanne Claxton Georg Mellitzer Caitlin Collin Nicoletta Kessaris William D Richardson Gérard GradwohlSiew-Lan Ang Disease Models & Mechanisms Published 1 January 2013Full details
Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors Authors (5) Carol H Yan Martin LevesqueSuzanne Claxton Randy L JohnsonSiew-Lan Ang Journal of Neuroscience Published 31 August 2011Full details
