Svend Kjaer

A small molecule inhibitor of HER3: a proof-of-concept study

Authors (17)

Audrey Colomba
Martina Fitzek
Roger George
Gregory Weitsman
Selene Roberts
Laura Zanetti-Domingues
[...]
Bram Snijders
Tony Ng
Marisa Martin-Fernandez
David M Smith
Peter Parker

Biochemical Journal

Published 10 September 2020

Crick labs/ facilities

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Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Authors (8)

Ottilie von Loeffelholz
Andrew Purkiss
Luyan Cao
Svend Kjaer
Naoko Kogata
Guillaume Romet-Lemonne
Michael Way
Carolyn A Moores

Biology Open

Published 31 July 2020

Crick labs/ facilities

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Scalable and robust SARS-CoV-2 testing in an academic center

Authors (81)

Jim Aitken
Karen Ambrose
Sam Barrell
Rupert Beale
Ganka Bineva-Todd
Dhruva Biswas
[...]
Sophia Ward
Wai Keong Wong
Joshua Wright
Mary Wu
The Crick COVID-19 Consortium

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Authors (12)

Joanna R Kelly
Silvia Martini
Nicola Brownlow
Dhira Joshi
Stefania Federico
Shirin Jamshidi
[...]
Nicola Lockwood
Khondaker Miraz Rahman
Franca Fraternali
Peter Parker
Tanya Soliman

Nature Communications

Published 13 March 2020

Crick labs/ facilities

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Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen

Authors (12)

Carrie R Willcox
Pierre Vantourout
Mahboob Salim
Iva Zlatareva
Daisy Melandri
Leonor Zanardo
[...]
Svend Kjaer
Mark Jeeves
Fiyaz Mohammed
Adrian Hayday
Benjamin E Willcox

Immunity

Published 19 November 2019

Crick labs/ facilities

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Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

Authors (14)

Benjamin N Atkinson
David Steadman
Yuguang Zhao
James Sipthorp
Luca Vecchia
Reinis R Ruza
[...]
Amy Monaghan
Svend Kjaer
Magda Bictash
E Yvonne Jones
Paul V Fish

MedChemComm

Published 1 August 2019

Crick labs/ facilities

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The Rho-family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

Authors (13)

Ahmed Elbediwy
Yixiao Zhang
Mathias Cobbaut
Philippe Riou
Ray S Tan
Selene K Roberts
[...]
Svend Kjaer
Marisa L Martin-Fernandez
Barry Thompson
Neil McDonald
Peter Parker

Journal of Cell Science

Published 25 April 2019

Crick labs/ facilities

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α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

Authors (19)

Oliver Gordon
Conor Henry
Naren Srinivasan
Susan Ahrens
Anna Franz
Safia Deddouche
[...]
Luis Teixeira
Barry Thompson
Marc S Dionne
Will Wood
Caetano Reis e Sousa

eLife

Published 27 September 2018

Crick labs/ facilities

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Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection

Authors (11)

Anna Napolitano
Annemarthe G van der Veen
Monique Bunyan
Annabel Borg
David Frith
Steven Howell
Svend Kjaer
Antje Beling
Bram Snijders
Klaus-Peter Knobeloch
Eva Frickel

Journal of Immunology

Published 15 July 2018

Crick labs/ facilities

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The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells

Authors (9)

Annemarthe G van der Veen
Pierre V Maillard
Jan Marten Schmidt
Sonia Lee
Safia Deddouche-Grass
Annabel Borg
Svend Kjaer
Bram Snijders
Caetano Reis e Sousa

EMBO Journal

Published 15 February 2018

Crick labs/ facilities

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VE-cadherin-mediated epigenetic regulation of endothelial gene expression

Authors (21)

Marco F Morini
Costanza Giampietro
Monica Corada
Federica Pisati
Elisa Lavarone
Sara I Cunha
[...]
Ugo Cavallaro
Diego Pasini
Dinis Calado
Elisabetta Dejana
Andrea Taddei

Circulation Research

Published 19 January 2018

Crick labs/ facilities

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Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

Authors (13)

Sandra Kümper
Thorsten Gantke
Chao-Sheng Chen
Yasmina Soneji
Michael J Pattison
Probir Chakravarty
[...]
Carl Haslam
Bill J Leavens
David House
David J Powell
Steve Ley

Biochemical Journal

Published 11 January 2018

Crick labs/ facilities

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Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

Authors (19)

Irene Sanjuan Nandin
Carol Fong
Cecilia Deantonio
Juan A Torreno-Pina
Simone Pecetta
Paula Maldonado
[...]
Alex K Shalek
Eric Meffre
Pascal Poignard
Dennis R Burton
Facundo D Batista

Journal of Experimental Medicine

Published 24 July 2017

Crick labs/ facilities

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PKCε switches Aurora B specificity to exit the abscission checkpoint

Authors (5)

Tanya Pike
Nicola Brownlow
Svend Kjaer
Jeremy Carlton
Peter Parker

Nature Communications

Published 22 December 2016

Crick labs/ facilities

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Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN

Authors (13)

Julian Stingele
Roberto Bellelli
Ferdinand Alte
Graeme Hewitt
Grzegorz Sarek
Sarah L Maslen
[...]
Svend Kjaer
John A Tainer
J Mark Skehel
Michael Groll
Simon Boulton

Molecular Cell

Published 17 November 2016

Crick labs

Simon Boulton

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A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells

Authors (6)

Pavel Hanč
Oliver Schulz
Hanna Fischbach
Stephen R Martin
Svend Kjaer
Caetano Reis e Sousa

EMBO Journal

Published 15 November 2016

Crick labs/ facilities

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aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization

Authors (17)

Erika V Soriano
Marina E Ivanova
Georgina Fletcher
Philippe Riou
Philip P Knowles
Karin Barnouin
[...]
Nicola O'Reilly
Bram Snijders
Peter Parker
Barry Thompson
Neil McDonald

Developmental Cell

Published 22 August 2016

Crick labs/ facilities

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Isoform diversity in the Arp2/3 complex determines actin filament dynamics

Authors (7)

Jasmine VG Abella
Chiara Galloni
Julien Pernier
David Barry
Svend Kjaer
Marie-France Carlier
Michael Way

Nature Cell Biology

Published 1 January 2016

Crick labs/ facilities

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Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens

Authors (12)

Pavel Hanč
Takashi Fujii
Salvador Iborra
Yurika Yamada
Jatta Huotari
Oliver Schulz
[...]
Svend Kjaer
Michael Way
David Sancho
Keiichi Namba
Caetano Reis e Sousa

Immunity

Published 19 May 2015

Crick labs/ facilities

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Svend Kjaer

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Journal

A small molecule inhibitor of HER3: a proof-of-concept study

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Scalable and robust SARS-CoV-2 testing in an academic center

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

The Rho-family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection

The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells

VE-cadherin-mediated epigenetic regulation of endothelial gene expression

Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

PKCε switches Aurora B specificity to exit the abscission checkpoint

Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN

A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells

aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization

Isoform diversity in the Arp2/3 complex determines actin filament dynamics

Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens

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