Svend Kjaer

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Authors (22)

Edgar Gonzalez-Rodriguez
Mia Zol-Hanlon
Ganka Bineva-Todd
Andrea Marchesi
Mark Skehel
Keira E Mahoney
[...]
Robert Wilkinson
Emma C Wall
Ramón Hurtado-Guerrero
Stacy A Malaker
Ben Schumann

ACS Central Science

Published 22 March 2023

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Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Authors (68)

G Tut
T Lancaster
M Krutikov
P Sylla
D Bone
E Spalkova
[...]
A Irwin-Singer
A Hayward
A Copas
L Shallcross
P Moss

Nature Aging

Published 1 January 2023

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A KLK6 activity-based probe reveals a role for KLK6 activity in pancreatic cancer cell invasion

Authors (11)

Leran Zhang
Scott Lovell
Elena De Vita
Pravin Kumar Ankush Jagtap
Daniel Lucy
Andrea Goya Grocin
Svend Kjaer
Annabel Borg
Janosch Hennig
Aubry K Miller
Edward W Tate

Journal of the American Chemical Society

Published 14 December 2022

Crick labs/ facilities

Structural Biology

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Cell-specific bioorthogonal tagging of glycoproteins

Authors (31)

Anna Cioce
Bea Calle
Tatiana Rizou
Sarah C Lowery
Vicky Bridgeman
Keira E Mahoney
[...]
Stuart M Haslam
Sabine L Flitsch
Stacy A Malaker
Ilaria Malanchi
Ben Schumann

Nature Communications

Published 25 October 2022

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WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Authors (19)

Mary Wu
Edward J Carr
Ruth Harvey
Harriet Mears
Svend Kjaer
Hermaleigh Townsley
[...]
Bryan Williams
Sonia Gandhi
Charles Swanton
Emma C Wall
David LV Bauer

The Lancet

Published 17 December 2022

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Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Authors (64)

Annika Fendler
Scott Shepherd
Lewis Au
Mary Wu
Ruth Harvey
Katalin Wilkinson
[...]
Emma Nicholson
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic

Cell Reports Medicine

Published 18 October 2022

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Structural analysis and development of Notum fragment screening hits

Authors (21)

Yuguang Zhao
William Mahy
Nicky J Willis
Hannah L Woodward
David Steadman
Elliott D Bayle
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
Paul V Fish
E Yvonne Jones

ACS Chemical Neuroscience

Published 6 July 2022

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Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)

Nicky J Willis
William Mahy
James Sipthorp
Yuguang Zhao
Hannah L Woodward
Benjamin N Atkinson
[...]
Patricia C Salinas
Jean-Paul Vincent
E Yvonne Jones
Paul Whiting
Paul V Fish

Journal of Medicinal Chemistry

Published 26 May 2022

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Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Authors (62)

Annika Fendler
Scott Shepherd
Lewis Au
Mary Wu
Ruth Harvey
Andreas M Schmitt
[...]
Emma Nicholson
Susanna Walker
James Larkin
Samra Turajlic
The CAPTURE consortium

The Lancet

Published 5 March 2022

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Three-dose vaccination elicits neutralising antibodies against omicron

Authors (26)

Mary Wu
Emma C Wall
Edward J Carr
Ruth Harvey
Hermaleigh Townsley
Harriet Mears
[...]
Vincenzo Libri
Bryan Williams
Sonia Gandhi
Charles Swanton
David LV Bauer

The Lancet

Published 19 February 2022

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Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Authors (65)

Annika Fendler
Scott Shepherd
Lewis Au
Katalin Wilkinson
Mary Wu
Andreas M Schmitt
[...]
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic
CAPTURE consortium

Cancer Cell

Published 14 February 2022

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Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Authors (86)

The Lancet

Published 18 September 2021

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Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

Authors (30)

Nikhil Faulkner
Kevin Ng
Mary Wu
Ruth Harvey
Marios Margaritis
Stavroula Paraskevopoulou
[...]
Michael Howell
David LV Bauer
Eleni Nastouli
SAFER Investigators
George Kassiotis

eLife

Published 29 July 2021

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MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Authors (10)

Chiara Galloni
Davide Carra
Jasmine VG Abella
Svend Kjaer
Pavithra Singaravelu
David Barry
Naoko Kogata
Christophe Guérin
Laurent Blanchoin
Michael Way

Journal of Cell Biology

Published 2 August 2021

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SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Authors (40)

Annachiara Rosa
Val Pye
Carl Graham
Luke Muir
Jeffrey Seow
Kevin Ng
[...]
Richard S Tedder
George Kassiotis
Laura E Mccoy
Katie J Doores
Peter Cherepanov

Science advances

Published 28 May 2021

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Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Authors (14)

Anna Cioce
Ganka Bineva-Todd
Anthony J Agbay
Junwon Choi
Thomas M Wood
Marjoke F Debets
[...]
Omur Yilmaz Tastan
Svend Kjaer
Jacob T Bush
Carolyn R Bertozzi
Ben Schumann

ACS Chemical Biology

Published 15 October 2021

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Community-wide experimental evaluation of the PROSS stability-design method

Authors (33)

Yoav Peleg
Renaud Vincentelli
Brett M Collins
Kai-En Chen
Emma K Livingstone
Saroja Weeratunga
[...]
Peggy Stolt-Bergner
Christian Aigner
Sabine Suppmann
Adi Goldenzweig
Sarel J Fleishman

Journal of Molecular Biology

Published 25 June 2021

Crick labs/ facilities

Structural Biology

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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Authors (14)

Sarah Adams
Andrew G Purkiss
Phillip P Knowles
Andrea Nans
David Briggs
Annabel Borg
[...]
Aaron J Borg
Pauline B McIntosh
Frankie Houghton
Svend Kjaer
Neil McDonald

Structure

Published 1 July 2021

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Research case studies

PhD student recruitment

Cut + Paste exhibition

Coronavirus (COVID-19) research

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Svend Kjaer

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Structural Biology

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Crick Pre-Crick

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

A KLK6 activity-based probe reveals a role for KLK6 activity in pancreatic cancer cell invasion

Cell-specific bioorthogonal tagging of glycoproteins

WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies

Structural analysis and development of Notum fragment screening hits

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Three-dose vaccination elicits neutralising antibodies against omicron

Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Community-wide experimental evaluation of the PROSS stability-design method

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

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