Svend Kjaer

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Authors (40)

Annachiara Rosa
Valerie Pye
Carl Graham
Luke Muir
Jeffrey Seow
Kevin Ng
[...]
Richard S Tedder
George Kassiotis
Laura E Mccoy
Katie J Doores
Peter Cherepanov

Science advances

Published 22 April 2021

Crick labs/ facilities

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Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Authors (14)

Anna Cioce
Ganka Bineva-Todd
Anthony J Agbay
Junwon Choi
Thomas M Wood
Marjoke F Debets
[...]
Omur Yilmaz Tastan
Svend Kjaer
Jacob T Bush
Carolyn R Bertozzi
Ben Schumann

ACS Chemical Biology

Published 9 April 2021

Crick labs/ facilities

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Community-wide experimental evaluation of the PROSS stability-design method

Authors (33)

Yoav Peleg
Renaud Vincentelli
Brett M Collins
Kai-En Chen
Emma K Livingstone
Saroja Weeratunga
[...]
Peggy Stolt-Bergner
Christian Aigner
Sabine Suppmann
Adi Goldenzweig
Sarel J Fleishman

Journal of Molecular Biology

Published 25 June 2021

Crick labs/ facilities

Structural Biology

Full details

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Authors (14)

Sarah Adams
Andrew G Purkiss
Phillip P Knowles
Andrea Nans
David Briggs
Annabel Borg
[...]
Aaron J Borg
Pauline B McIntosh
Francesca M Houghton
Svend Kjaer
Neil McDonald

Structure

Published 22 January 2021

Crick labs/ facilities

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Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Authors (11)

Ilaria Gori
Roger George
Andrew G Purkiss
Stephanie Strohbuecker
Rebecca A Randall
Roksana Ogrodowicz
Virginie Carmignac
Laurence Faivre
Dhira Joshi
Svend Kjaer
Caroline Hill

eLife

Published 8 January 2021

Crick labs/ facilities

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Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Authors (47)

Kevin Ng
Nikhil Faulkner
Georgina H Cornish
Annachiara Rosa
Ruth Harvey
Saira Hussain
[...]
Steve Gamblin
Laura E Mccoy
Peter Cherepanov
Eleni Nastouli
George Kassiotis

Science

Published 11 December 2020

Crick labs/ facilities

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5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Authors (18)

William Mahy
Nicky J Willis
Yuguang Zhao
Hannah L Woodward
Fredrik Svensson
James Sipthorp
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
E Yvonne Jones
Paul V Fish

Journal of Medicinal Chemistry

Published 12 November 2020

Crick labs/ facilities

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Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Authors (27)

Marjoke F Debets
Omur Yilmaz Tastan
Simon P Wisnovsky
Stacy A Malaker
Nikos Angelis
Leonhard KR Moeckl
[...]
Michael C Bassik
WE Moerner
Vivian Li
Carolyn R Bertozzi
Ben Schumann

Proceedings of the National Academy of Sciences of USA

Published 13 October 2020

Crick labs/ facilities

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A small molecule inhibitor of HER3: a proof-of-concept study

Authors (17)

Audrey Colomba
Martina Fitzek
Roger George
Gregory Weitsman
Selene Roberts
Laura Zanetti-Domingues
[...]
Bram Snijders
Tony Ng
Marisa Martin-Fernandez
David M Smith
Peter Parker

Biochemical Journal

Published 10 September 2020

Crick labs/ facilities

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Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Authors (8)

Ottilie von Loeffelholz
Andrew Purkiss
Luyan Cao
Svend Kjaer
Naoko Kogata
Guillaume Romet-Lemonne
Michael Way
Carolyn A Moores

Biology Open

Published 31 July 2020

Crick labs/ facilities

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Scalable and robust SARS-CoV-2 testing in an academic center

Authors (81)

Jim Aitken
Karen Ambrose
Sam Barrell
Rupert Beale
Ganka Bineva-Todd
Dhruva Biswas
[...]
Sophia Ward
Wai Keong Wong
Joshua Wright
Mary Wu
The Crick COVID-19 Consortium

Evidence that STK19 is not an NRAS-dependent melanoma driver

Authors (11)

Cell

Published 11 June 2020

Crick labs/ facilities

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The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Authors (12)

Joanna R Kelly
Silvia Martini
Nicola Brownlow
Dhira Joshi
Stefania Federico
Shirin Jamshidi
[...]
Nicola Lockwood
Khondaker Miraz Rahman
Franca Fraternali
Peter Parker
Tanya Soliman

Nature Communications

Published 13 March 2020

Crick labs/ facilities

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Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen

Authors (12)

Carrie R Willcox
Pierre Vantourout
Mahboob Salim
Iva Zlatareva
Daisy Melandri
Leonor Zanardo
[...]
Svend Kjaer
Mark Jeeves
Fiyaz Mohammed
Adrian Hayday
Benjamin E Willcox

Immunity

Published 19 November 2019

Crick labs/ facilities

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Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

Authors (14)

Benjamin N Atkinson
David Steadman
Yuguang Zhao
James Sipthorp
Luca Vecchia
Reinis R Ruza
[...]
Amy Monaghan
Svend Kjaer
Magda Bictash
E Yvonne Jones
Paul V Fish

MedChemComm

Published 1 August 2019

Crick labs/ facilities

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The Rho-family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

Authors (13)

Ahmed Elbediwy
Yixiao Zhang
Mathias Cobbaut
Philippe Riou
Ray S Tan
Selene K Roberts
[...]
Svend Kjaer
Marisa L Martin-Fernandez
Barry J Thompson
Neil McDonald
Peter Parker

Journal of Cell Science

Published 25 April 2019

Crick labs/ facilities

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α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

Authors (19)

Oliver Gordon
Conor Henry
Naren Srinivasan
Susan Ahrens
Anna Franz
Safia Deddouche
[...]
Luis Teixeira
Barry Thompson
Marc S Dionne
Will Wood
Caetano Reis e Sousa

eLife

Published 27 September 2018

Crick labs/ facilities

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Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection

Authors (11)

Anna Napolitano
Annemarthe G van der Veen
Monique Bunyan
Annabel Borg
David Frith
Steven Howell
Svend Kjaer
Antje Beling
Bram Snijders
Klaus-Peter Knobeloch
Eva-Maria Frickel

Journal of Immunology

Published 15 July 2018

Crick labs/ facilities

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The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells

Authors (9)

Annemarthe G van der Veen
Pierre V Maillard
Jan Marten Schmidt
Sonia Lee
Safia Deddouche-Grass
Annabel Borg
Svend Kjaer
Bram Snijders
Caetano Reis e Sousa

EMBO Journal

Published 15 February 2018

Crick labs/ facilities

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Svend Kjaer

STP DEPUTY

Structural Biology

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Crick Pre-Crick

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Journal

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Community-wide experimental evaluation of the PROSS stability-design method

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

A small molecule inhibitor of HER3: a proof-of-concept study

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Scalable and robust SARS-CoV-2 testing in an academic center

Evidence that STK19 is not an NRAS-dependent melanoma driver

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

The Rho-family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection

The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells

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